SCI和EI收录∣中国化工学会会刊

中国化学工程学报 ›› 2020, Vol. 28 ›› Issue (12): 3086-3095.DOI: 10.1016/j.cjche.2020.07.007

• Chemical Engineering Thermodynamics • 上一篇    下一篇

Insight into solute-solute and solute-solvent interactions of semicarbazide hydrochloride in water and D-glucose/D-sucrose+water solutions at temperatures (293.15 to 318.15) K

Ankita1,2, Dinesh Chand3, Anil Kumar Nain1   

  1. 1 Department of Chemistry, Dyal Singh College, University of Delhi, New Delhi 110003, India;
    2 Department of Chemistry, University of Delhi, Delhi 110007, India;
    3 Department of Chemistry, Amity University Dubai Campus, Dubai International Academic City, Dubai, UAE
  • 收稿日期:2020-01-26 修回日期:2020-06-27 出版日期:2020-12-28 发布日期:2021-01-11
  • 通讯作者: Anil Kumar Nain
  • 基金资助:
    The authors are thankful to the Head, Department of Chemistry (University of Delhi), Delhi, India for encouragement and providing facilities.

Insight into solute-solute and solute-solvent interactions of semicarbazide hydrochloride in water and D-glucose/D-sucrose+water solutions at temperatures (293.15 to 318.15) K

Ankita1,2, Dinesh Chand3, Anil Kumar Nain1   

  1. 1 Department of Chemistry, Dyal Singh College, University of Delhi, New Delhi 110003, India;
    2 Department of Chemistry, University of Delhi, Delhi 110007, India;
    3 Department of Chemistry, Amity University Dubai Campus, Dubai International Academic City, Dubai, UAE
  • Received:2020-01-26 Revised:2020-06-27 Online:2020-12-28 Published:2021-01-11
  • Contact: Anil Kumar Nain
  • Supported by:
    The authors are thankful to the Head, Department of Chemistry (University of Delhi), Delhi, India for encouragement and providing facilities.

摘要: The solute-solute and solute-solvent interactions of drug semicarbazide hydrochloride with carbohydrates (D-glucose/D-sucrose) are investigated by using volumetric, viscometric and acoustic properties. The measurements of the densities ρ, ultrasonic speeds u, and viscosities η. of semicarbazide hydrochloride in 5% and 10% D-glucose/D-sucrose+water (w/w) solutions were carried out at temperatures (293.15-318.15) K and at pressure, p=101 kPa. The apparent molar volumes, Vϕ, limiting apparent molar volumes,Vϕ°, apparent molar compressibilities, Ks, ϕ, limiting apparent molar compressibilities, Ks,ϕ°, partial molar expansibilities, Eϕ°, transfer volumes, Vϕ,tr° and transfer compressibilities, Ks,ϕ,tr° have been calculated from the experimental data. The viscosity data were examined by using the Jones-Dole equation and the viscosity A and B coefficients were evaluated. The results are discussed in terms of solute-solute and solute-solvent interactions in these solutions. The structure making/breaking ability of semicarbazide hydrochloride is examined using the sign of temperature derivative of B-coefficient, dB/dT.

关键词: Density, Ultrasonic speed, Viscosity, Semicarbazide hydrochloride, Carbohydrates, Solute-solvent interactions

Abstract: The solute-solute and solute-solvent interactions of drug semicarbazide hydrochloride with carbohydrates (D-glucose/D-sucrose) are investigated by using volumetric, viscometric and acoustic properties. The measurements of the densities ρ, ultrasonic speeds u, and viscosities η. of semicarbazide hydrochloride in 5% and 10% D-glucose/D-sucrose+water (w/w) solutions were carried out at temperatures (293.15-318.15) K and at pressure, p=101 kPa. The apparent molar volumes, Vϕ, limiting apparent molar volumes,Vϕ°, apparent molar compressibilities, Ks, ϕ, limiting apparent molar compressibilities, Ks,ϕ°, partial molar expansibilities, Eϕ°, transfer volumes, Vϕ,tr° and transfer compressibilities, Ks,ϕ,tr° have been calculated from the experimental data. The viscosity data were examined by using the Jones-Dole equation and the viscosity A and B coefficients were evaluated. The results are discussed in terms of solute-solute and solute-solvent interactions in these solutions. The structure making/breaking ability of semicarbazide hydrochloride is examined using the sign of temperature derivative of B-coefficient, dB/dT.

Key words: Density, Ultrasonic speed, Viscosity, Semicarbazide hydrochloride, Carbohydrates, Solute-solvent interactions