The facile method developed for preparing polyvinylidene fluoride plasma separation membrane via macromolecular interaction

doi:10.1016/j.cjche.2022.07.021

中国化学工程学报 ›› 2022, Vol. 49 ›› Issue (9): 140-149.DOI: 10.1016/j.cjche.2022.07.021

• Special Column: Membranes for Life Science • 上一篇下一篇

The facile method developed for preparing polyvinylidene fluoride plasma separation membrane via macromolecular interaction

Juanjuan Liu^1,2, Xiaolong Lu^2,4, Guiming Shu¹, Ke Li³, Shuyun Zheng², Xiao Kong², Tao Li¹, Jun Yang⁵

1. Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Institute of Hepatobiliary Disease, The Third Central Hospital Affiliated to Nankai University, Tianjin Third Central Hospital, Tianjin 300170, China;
2. State Key Laboratory of Separation Membrane and Membrane Processes, School of Material Science and Engineering, Institute of Biological and Chemical Engineering, Tiangong University, Tianjin 300387, China;
3. Clinical Laboratory, Tianjin Children's Hospital, Tianjin 300074, China;
4. State Key Laboratory of Membrane Materials and Membrane Applications, Tianjin Motimo Membrane Tech. Co., Ltd, Tianjin 300457, China;
5. The Key Laboratory of Bioactive Materials, College of Life Science, Nankai University, Tianjin 300000, China

收稿日期:2022-02-10 修回日期:2022-07-21 发布日期:2022-10-19
通讯作者: Xiaolong Lu,E-mail:13920286131@163.com;Tao Li,E-mail:13802091974@163.com
基金资助:
The authors gratefully acknowledge the National Natural Science Foundation of China (21776216), Tianjin Key Laboratory Project (16PTSYJC00210), Program for Innovative Research Team in University of Tianjin (TD13-5044), Science and technology support project of Tianjin (20YFZCSY00310, 21ZXGWSY00040), State Key Laboratory of Separation Membranes and Membrane Processes (Tiangong University), Youth Science Foundation of Tianjin (21JCQNJC00100), Tianjin Health Science and Technology Project (TJWJ2021MS014).

The facile method developed for preparing polyvinylidene fluoride plasma separation membrane via macromolecular interaction

Juanjuan Liu^1,2, Xiaolong Lu^2,4, Guiming Shu¹, Ke Li³, Shuyun Zheng², Xiao Kong², Tao Li¹, Jun Yang⁵

1. Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Institute of Hepatobiliary Disease, The Third Central Hospital Affiliated to Nankai University, Tianjin Third Central Hospital, Tianjin 300170, China;
2. State Key Laboratory of Separation Membrane and Membrane Processes, School of Material Science and Engineering, Institute of Biological and Chemical Engineering, Tiangong University, Tianjin 300387, China;
3. Clinical Laboratory, Tianjin Children's Hospital, Tianjin 300074, China;
4. State Key Laboratory of Membrane Materials and Membrane Applications, Tianjin Motimo Membrane Tech. Co., Ltd, Tianjin 300457, China;
5. The Key Laboratory of Bioactive Materials, College of Life Science, Nankai University, Tianjin 300000, China

Received:2022-02-10 Revised:2022-07-21 Published:2022-10-19
Contact: Xiaolong Lu,E-mail:13920286131@163.com;Tao Li,E-mail:13802091974@163.com
Supported by:
The authors gratefully acknowledge the National Natural Science Foundation of China (21776216), Tianjin Key Laboratory Project (16PTSYJC00210), Program for Innovative Research Team in University of Tianjin (TD13-5044), Science and technology support project of Tianjin (20YFZCSY00310, 21ZXGWSY00040), State Key Laboratory of Separation Membranes and Membrane Processes (Tiangong University), Youth Science Foundation of Tianjin (21JCQNJC00100), Tianjin Health Science and Technology Project (TJWJ2021MS014).

摘要/Abstract

摘要： The design of membrane pore is critical for membrane preparation. Polyvinylidene fluoride (PVDF) membrane exhibits outstanding properties in the water-treatment field. However, it is a huge challenge to prepare PVDF macro-pore plasma separation membrane by non-solvent induced phase separation (NIPS). Herein, a facile strategy is proposed to prepare PVDF macro-pore plasma separation membrane via macromolecular interaction. ATR-FTIR and ¹H NMR showed that the intermolecular interaction existed between polyethylene oxide (PEO) and polyvinylpyrrolidone (PVP). It could significantly affect the PVDF macro-pore membrane structure. The maximum pore of the PVDF membrane could be effectively adjusted from small-pore/medium-pore to macro-pore by changing the molecular weight of PEO. The PVDF macro-pore membrane was obtained successfully when PEO-200 k existed with PVP. It exhibited higher plasma separation properties than the currently used plasma separation membrane. Moreover, it had excellent hemocompatibility due to the similar plasma effect, hemolysis, prothrombin time, blood effect and complement C_3a effect with the current utilized plasma separation membrane, implying its great potential application. The proposed facile strategy in this work provides a new method to prepare PVDF macro-pore plasma separation membrane by NIPS.

关键词: Membranes, Macro-pore plasma separation membrane, Hemocompatibility, Purification, Biomedical engineering

Abstract: The design of membrane pore is critical for membrane preparation. Polyvinylidene fluoride (PVDF) membrane exhibits outstanding properties in the water-treatment field. However, it is a huge challenge to prepare PVDF macro-pore plasma separation membrane by non-solvent induced phase separation (NIPS). Herein, a facile strategy is proposed to prepare PVDF macro-pore plasma separation membrane via macromolecular interaction. ATR-FTIR and ¹H NMR showed that the intermolecular interaction existed between polyethylene oxide (PEO) and polyvinylpyrrolidone (PVP). It could significantly affect the PVDF macro-pore membrane structure. The maximum pore of the PVDF membrane could be effectively adjusted from small-pore/medium-pore to macro-pore by changing the molecular weight of PEO. The PVDF macro-pore membrane was obtained successfully when PEO-200 k existed with PVP. It exhibited higher plasma separation properties than the currently used plasma separation membrane. Moreover, it had excellent hemocompatibility due to the similar plasma effect, hemolysis, prothrombin time, blood effect and complement C_3a effect with the current utilized plasma separation membrane, implying its great potential application. The proposed facile strategy in this work provides a new method to prepare PVDF macro-pore plasma separation membrane by NIPS.

Key words: Membranes, Macro-pore plasma separation membrane, Hemocompatibility, Purification, Biomedical engineering

Juanjuan Liu, Xiaolong Lu, Guiming Shu, Ke Li, Shuyun Zheng, Xiao Kong, Tao Li, Jun Yang. The facile method developed for preparing polyvinylidene fluoride plasma separation membrane via macromolecular interaction[J]. 中国化学工程学报, 2022, 49(9): 140-149.

参考文献

[1] H. Kanemura, H. Hayashi, S. Hagiwara, T. Otani, K. Haratani, K. Yonesaka, A. Ito, M. Kudo, K. Nakagawa, Severe immune-related hepatitis treated with plasma exchange, J. Thorac. Oncol. 15 (3) (2020) e39-e42
[2] L. Rostaing, J. Clin. Apher. 36 (3) (2021) 408-419
[3] M.E. Williams, R.A. Balogun, Principles of separation:Indications and therapeutic targets for plasma exchange, Clin. J. Am. Soc. Nephrol. 9 (1) (2014) 181-190
[4] R. Hirano, K. Namazuda, N. Hirata, Double filtration plasmapheresis:Review of current clinical applications, Ther. Apher. Dial. 25 (2) (2021) 145-151
[5] N. Pal, M. Agarwal, Advances in materials process and separation mechanism of the membrane towards hydrogen separation, Int. J. Hydrog. Energy 46 (53) (2021) 27062-27087
[6] Z.H. Xu, Z.X. Fan, C. Shen, Q. Meng, G.L. Zhang, C.J. Gao, Porous composite membrane based on organic substrate for molecular sieving:Current status, opportunities and challenges, Adv. Membr. 2 (2022) 100027
[7] R. Hirano, K. Namazuda, J. Suemitsu, T. Harashima, N. Hirata, Plasma separation using a membrane, Transfus. Apher. Sci. 56 (5) (2017) 649-653
[8] M.R. He, S.Y. Zhang, Y.L. Su, R.N. Zhang, Y.N. Liu, Z.Y. Jiang, Manipulating membrane surface porosity and pore size by in situ assembly of Pluronic F127 and tannin, J. Membr. Sci. 556 (2018) 285-292
[9] J.X. Wang, M. Qiu, C.J. He, A zwitterionic polymer/PES membrane for enhanced antifouling performance and promoting hemocompatibility, J. Membr. Sci. 606 (2020) 118119
[10] Y.N. Wu, J.X. Zeng, Y.J. Zeng, H. Zhou, G.Q. Liu, J. Jian, J. Ding, Polyethersulfone-polyvinylpyrrolidone composite membranes:Effects of polyvinylpyrrolidone content and polydopamine coating on membrane morphology, structure and performances, Chin. J. Chem. Eng. 38 (2021) 84-97
[11] W.J. Ding, M. Chen, M. Zhou, Z.X. Zhong, Z.L. Cui, W.H. Xing, Fouling behavior of poly(vinylidene fluoride) (PVDF) ultrafiltration membrane by polyvinyl alcohol (PVA) and chemical cleaning method, Chin. J. Chem. Eng. 28 (12) (2020) 3018-3026
[12] A. Venault, Y.T. Chin, I. Maggay, C.C. Yeh, Y. Chang, Poly(vinylidene fluoride)/poly(styrene-co-acrylic acid) nanofibers as potential materials for blood separation, J. Membr. Sci. 641 (2022) 119881
[13] C.N. Liu, W.Y. Wang, Y.L. Li, F.Y. Cui, C.C. Xie, L.Y. Zhu, B.J. Shan, PMWCNT/PVDF ultrafiltration membranes with enhanced antifouling properties intensified by electric field for efficient blood purification, J. Membr. Sci. 576 (2019) 48-58
[14] A.L. Gao, F. Liu, H.Y. Shi, L.X. Xue, Controllable transition from finger-like pores to inter-connected pores of PLLA membranes, J. Membr. Sci. 478 (2015) 96-104
[15] J.Q. Zhao, H.R. Han, Q.Q. Wang, C.Y. Yan, D.Y. Li, J. Yang, X. Feng, N. Yang, Y.P. Zhao, L. Chen, Hydrophilic and anti-fouling PVDF blend ultrafiltration membranes using polyacryloylmorpholine-based triblock copolymers as amphiphilic modifiers, React. Funct. Polym. 139 (2019) 92-101
[16] D.Y. Wei, S.Y. Zhou, M.S. Li, A.L. Xue, Y. Zhang, Y.J. Zhao, J. Zhong, D.W. Yang, PVDF/palygorskite composite ultrafiltration membranes:Effects of nano-clay particles on membrane structure and properties, Appl. Clay Sci. 181 (2019) 105171
[17] H.L. Liu, X.J. Liao, The effects of fluorocarbon special surfactant (FS-30) additive on the phase inversion, morphology and separation performance of poly(vinylidene fluoride) (PVDF) membranes, Sep. Purif. Technol. 212 (2019) 619-631
[18] C.Y. Yang, G.D. Zhu, Z. Yi, Y.Y. Qiu, L.F. Liu, C.J. Gao, Tailoring the pore size and permeability of isoporous membranes through blending with poly(ethylene glycol):Toward the balance of macro- and microphase separation, J. Membr. Sci. 598 (2020) 117755
[19] J.Q. Zhao, Q.Q. Wang, J. Yang, Y. Li, Z.Y. Liu, L.Q. Zhang, Y.P. Zhao, S.X. Zhang, L. Chen, Comb-shaped amphiphilic triblock copolymers blend PVDF membranes overcome the permeability-selectivity trade-off for protein separation, Sep. Purif. Technol. 239 (2020) 116596
[20] B.J. Cha, J.M. Yang, Effect of high-temperature spinning and PVP additive on the properties of PVDF hollow fiber membranes for microfiltration, Macromol. Res. 14 (6) (2006) 596-602
[21] X. Kong, X.L. Lu, K. Ren, Towards high-performance polysulfone membranes:A controllable membrane formation process using surfactant in NIPS, J. Taiwan Inst. Chem. Eng. 129 (2021) 171-179
[22] X.L. Dong, H.J. Shao, J.Y. Chang, S.H. Qin, Tailoring the dual role of styrene-maleic anhydride copolymer in the fabrication of polysulfone ultrafiltration membranes:Acting as a pore former and amphiphilic surface modifier, Sep. Purif. Technol. 283 (2022) 120219
[23] N. Naghdi Sedeh, M. Entezam, S. Hassan Jafari, H.A. Khonakdar, M. Abdouss, Morphology, drug release behavior, thermal, and mechanical properties of poly(ethylene oxide) (PEO)/poly(vinyl pyrrolidone) (PVP) blends, J. Appl. Polym. Sci. 135 (26) (2018) 46403
[24] S. Choudhary, R.J. Sengwa, Dielectric spectroscopy and viscosity studies of aqueous poly(ethylene oxide) and poly(vinyl pyrrolidone) blend, Indian J. Phys. 85 (11) (2011) 1591-1602
[25] S.W. Jin, H. Liu, X.J. Gao, Z.H. Lin, G.Q. Chen, D.Q. Wang, Seven organic salts assembled from hydrogen-bonds of N-H···O, O-H···O, and C-H···O between acidic compounds and bis(benzimidazole), J. Mol. Struct. 1075 (2014) 124-138
[26] A.K. Chamberlain, J.U. Bowie, Evaluation of C-H···O hydrogen bonds in native and misfolded proteins, J. Mol. Biol. 322 (3) (2002) 497-503
[27] M.M. Nolasco, P.M. Vaz, P.D. Vaz, P.J.A. Ribeiro-Claro, Exploring C-H···O hydrogen bonds in dihydrocoumarin from combined vibrational spectroscopy and DFT calculations, Chem. Phys. Lett. 551 (2012) 86-91
[28] Y.Y. Sheng, H.Y. Zhou, Z.B. Li, L.X. Chen, X.J. Wang, X.Y. Zhao, W. Li, Improved blood compatibility and cyto-compatibility of Zn-1Mg via plasma electrolytic oxidation, Materialia 5 (2019) 100244
[29] Y.T. Peng, X.Y. Feng, J.M. Jiang, L. Ren, Controllable polyvinylpyrrolidone modified Polystyrene divinylbenzene for efficient adsorption of bilirubin and improvement of hemocompatibility, Eur. Polym. J. 170 (2022) 111172
[30] R. Oriňaková, R. Gorejová, Z. Orságová Králová, L. Haverová, A. Oriňak, I. Maskal'ová, M. Kupková, M. Džupon, M. Baláž, M. Hrubovčáková, T. Sopčák, A. Zubrik, M. Oriňak, Evaluation of mechanical properties and hemocompatibility of open cell iron foams with polyethylene glycol coating, Appl. Surf. Sci. 505 (2020) 144634
[31] Z. Ma, X.L. Lu, C.R. Wu, Q.J. Gao, L.H. Zhao, H. Zhang, Z.Y. Liu, Functional surface modification of PVDF membrane for chemical pulse cleaning, J. Membr. Sci. 524 (2017) 389-399
[32] J.J. Liu, G.M. Shu, X.L. Lu, K. Li, X. Kong, S.Y. Zheng, R.H. Ma, T. Li, Alginate/HSA double-sided functional PVDF multifunctional composite membrane for bilirubin removal, Sep. Purif. Technol. 252 (2020) 117295
[33] X. Kong, Y.K. Sun, X.L. Lu, C.R. Wu, Facile preparation of persistently hydrophilic poly(vinylidene fluoride-co-trifluorochloroethylene) membrane based on in situ substitution reaction, J. Membr. Sci. 609 (2020) 118223
[34] G.J. Dahe, R.S. Teotia, S.S. Kadam, J.R. Bellare, The biocompatibility and separation performance of antioxidative polysulfone/vitamin E TPGS composite hollow fiber membranes, Biomaterials 32 (2) (2011) 352-365
[35] P. Wang, J.Q. Meng, M.L. Xu, T. Yuan, N. Yang, T. Sun, Y.F. Zhang, X.S. Feng, B.W. Cheng, A simple but efficient zwitterionization method towards cellulose membrane with superior antifouling property and biocompatibility, J. Membr. Sci. 492 (2015) 547-558
[36] X.F. Yu, Y.D. Zhu, T.H. Zhang, L. Deng, P.Y. Li, X.F. Wang, B.S. Hsiao, Heparinized thin-film composite membranes with sub-micron ridge structure for efficient hemodialysis, J. Membr. Sci. 599 (2020) 117706
[37] L.C. Xu, M.E. Meyerhoff, C.A. Siedlecki, Blood coagulation response and bacterial adhesion to biomimetic polyurethane biomaterials prepared with surface texturing and nitric oxide release, Acta Biomater. 84 (2019) 77-87
[38] S. Chapi, S. Raghu, H. Devendrappa, Enhanced electrochemical, structural, optical, thermal stability and ionic conductivity of (PEO/PVP) polymer blend electrolyte for electrochemical applications, Ionics 22 (6) (2016) 803-814
[39] T.M.F.F. Diniz, M.I.B. Tavares, NMR study of poly(vinylpyrrolidone)/poly(ethylene oxide) blends, J. Appl. Polym. Sci. 85 (14) (2002) 2820-2823
[40] J. Meyer, M. Ulbricht, Poly(ethylene oxide)-block-poly(methyl methacrylate) diblock copolymers as functional additive for poly(vinylidene fluoride) ultrafiltration membranes with tailored separation performance, J. Membr. Sci. 545 (2018) 301-311

The facile method developed for preparing polyvinylidene fluoride plasma separation membrane via macromolecular interaction

The facile method developed for preparing polyvinylidene fluoride plasma separation membrane via macromolecular interaction

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