Investigation on the synthesis conditions of poly(4-methyl-1-pentene) hollow fiber membrane with high gas permeability and strong tensile strength

doi:10.1016/j.cjche.2024.03.036

中国化学工程学报 ›› 2024, Vol. 75 ›› Issue (11): 25-34.DOI: 10.1016/j.cjche.2024.03.036

Investigation on the synthesis conditions of poly(4-methyl-1-pentene) hollow fiber membrane with high gas permeability and strong tensile strength

Changfeng Lu^1,2, Donghai Sheng¹, Lin Zhang¹, Beibei Feng¹, Yuan Li³

1. State Key Laboratory of Tribology in Advanced Equipment, Tsinghua University, Beijing 100084, China;
2. College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China;
3. Central Laboratory of Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China

收稿日期:2023-10-27 修回日期:2024-03-12 接受日期:2024-03-13 出版日期:2024-11-28 发布日期:2024-08-23
通讯作者: Donghai Sheng,E-mail:shengdonghai@mail.tsinghua.edu.cn;Lin Zhang,E-mail:zhanglin2020@mail.tsinghua.edu.cn;Yuan Li,E-mail:liyuan@cqmu.edu.cn
基金资助:
We acknowledge the support of this work by Science Fund of State Key Laboratory of Tribology, Tsinghua University (61012205321).

Investigation on the synthesis conditions of poly(4-methyl-1-pentene) hollow fiber membrane with high gas permeability and strong tensile strength

Changfeng Lu^1,2, Donghai Sheng¹, Lin Zhang¹, Beibei Feng¹, Yuan Li³

1. State Key Laboratory of Tribology in Advanced Equipment, Tsinghua University, Beijing 100084, China;
2. College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China;
3. Central Laboratory of Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China

Received:2023-10-27 Revised:2024-03-12 Accepted:2024-03-13 Online:2024-11-28 Published:2024-08-23
Contact: Donghai Sheng,E-mail:shengdonghai@mail.tsinghua.edu.cn;Lin Zhang,E-mail:zhanglin2020@mail.tsinghua.edu.cn;Yuan Li,E-mail:liyuan@cqmu.edu.cn
Supported by:
We acknowledge the support of this work by Science Fund of State Key Laboratory of Tribology, Tsinghua University (61012205321).

摘要/Abstract

摘要： Poly(4-methyl-1-pentene) hollow fiber membranes (PMP HFMs) are commonly used in gas separation membrane and artificial lung membrane in extracorporeal membrane oxygenation (ECMO), and its porous structure and mechanical properties have a significant impact on the performance of the membrane material. In our work, PMP HFMs were prepared by thermally induced phase separation method. Subsequently, through characterization analysis of powder X-ray diffraction, universal tensile machine, scanning electron microscope and other instruments, the effects of PMP concentration, diluent ratio, quenching temperature, air gap distance and winding speed on the membrane performance were systematically investigated to obtain optimal preparation conditions for PMP HFMs. The results showed that the PMP HFMs prepared under optimal conditions possessed good gas permeability with a nitrogen flux of 10.5 ml·MPa^-1·cm^-2·min^-1, a surface dense layer, and a good tensile strength of 9.33 MPa. We believed that this work could provide useful references for the application of PMP membranes in the medical field.

关键词: Extracorporeal membrane oxygenation, Poly(4-methyl-1-pentene) hollow fiber membranes, Thermally induced phase separation, Bicontinuous porous structure, Gas permeability

Abstract: Poly(4-methyl-1-pentene) hollow fiber membranes (PMP HFMs) are commonly used in gas separation membrane and artificial lung membrane in extracorporeal membrane oxygenation (ECMO), and its porous structure and mechanical properties have a significant impact on the performance of the membrane material. In our work, PMP HFMs were prepared by thermally induced phase separation method. Subsequently, through characterization analysis of powder X-ray diffraction, universal tensile machine, scanning electron microscope and other instruments, the effects of PMP concentration, diluent ratio, quenching temperature, air gap distance and winding speed on the membrane performance were systematically investigated to obtain optimal preparation conditions for PMP HFMs. The results showed that the PMP HFMs prepared under optimal conditions possessed good gas permeability with a nitrogen flux of 10.5 ml·MPa^-1·cm^-2·min^-1, a surface dense layer, and a good tensile strength of 9.33 MPa. We believed that this work could provide useful references for the application of PMP membranes in the medical field.

Key words: Extracorporeal membrane oxygenation, Poly(4-methyl-1-pentene) hollow fiber membranes, Thermally induced phase separation, Bicontinuous porous structure, Gas permeability

Changfeng Lu, Donghai Sheng, Lin Zhang, Beibei Feng, Yuan Li. Investigation on the synthesis conditions of poly(4-methyl-1-pentene) hollow fiber membrane with high gas permeability and strong tensile strength[J]. 中国化学工程学报, 2024, 75(11): 25-34.

参考文献

[1] A. Puleo, D. Paul, P. Wong, Gas sorption and transport in semicrystalline poly(4-methyl-1-pentene), Polymer 30 (7) (1989) 1357-1366.
[2] I. Michaljanicova, P. Slepicka, N. Slepickova Kasalkova, P. Sajdl, V. Svorcik, Plasma and laser treatment of PMP for biocompatibility improvement, Vacuu 107 (2014) 184-190.
[3] E.J. Samuel, S. Mohan, FTIR and FT Raman spectra and analysis of poly(4-methyl-1-pentene), Spectrochim. Acta A Mol. Biomol. Spectrosc. 60 (1-2) (2004) 19-24.
[4] G.J. Peek, H.M. Killer, R. Reeves, A.W. Sosnowski, R.K. Firmin, Early experience with a polymethyl pentene oxygenator for adult extracorporeal life support, ASAIO J. 48 (5) (2002) 480-482.
[5] R.J. Leonard, The transition from the bubble oxygenator to the microporous membrane oxygenator, Perfusion 18 (3) (2003) 179-183.
[6] A.H. Mostafavi, A. K. Mishra, M. Ulbricht, J.F.M. Denayer, S.S. Hosseini, Oxygenation and membrane oxygenators: Emergence, evolution and progress in material development and process enhancement for biomedical applications, J. Membr. Sci. Res. 7 (2021) 230-259.
[7] S. Markova, M. Shalygin, M. Pelzer, T. Gries, V. Teplyakov, Application prospects of dense gas separation hollow fibers based on poly(4-methyl-1-pentene), Chem. Pap. 74 (2020) 1917-1921.
[8] B.J. Cha, J.M. Yang, Preparation of poly(vinylidene fluoride) hollow fiber membranes for microfiltration using modified TIPS process, J. Membr. Sci. 291 (1-2) (2007) 191-198.
[9] K.H. Lee, S. Givens, D.B. Chase, J.F. Rabolt, Electrostatic polymer processing of isotactic poly(4-methyl-1-pentene) fibrous membrane, Polymer 47 (23) (2006) 8013-8018.
[10] T.Q. Zhang, Z.Q. Jia, W.J. Peng, S.D. Li, J.P. Wen, Preparation of 4-methyl-1-pentene membranes via non-solvent induced phase separation (NIPS), Eur. Polym. J. 178 (2022) 111480.
[11] L.H. Zhi, S.Y. Li, X.Q. He, Y.B. Feng, C. Cheng, S. Li, S.D. Sun, C.S. Zhao, In-situ modified polyethersulfone oxygenation membrane with improved hemocompatibility and gas transfer efficiency, J. Membr. Sci. 667 (2023) 121162.
[12] S. Horton, C. Thuys, M. Bennett, S. Augustin, M. Rosenberg, C. Brizard, Experience with the jostra rotaflow and QuadroxD oxygenator for ECMO, Perfusion 19 (1) (2004) 17-23.
[13] T. Yeager, S. Roy, Evolution of gas permeable membranes for extracorporeal membrane oxygenation, Artif. Organs 41 (8) (2017) 700-709.
[14] L. Lequier, S.B. Horton, D.M. McMullan, R.H. Bartlett, Extracorporeal membrane oxygenation circuitry, Pediatr. Crit. Care Med. 14 (5 Suppl 1) (2013) S7-S12.
[15] S. Agati, G. Ciccarello, N. Fachile, R.M. Scappatura, D. Grasso, D. Salvo, A. Undar, C. Mignosa, DIDECMO: A new polymethylpentene oxygenator for pediatric extracorporeal membrane oxygenation, ASAIO J. 52 (5) (2006) 509-512.
[16] G.R. Guillen, Y.J. Pan, M.H. Li, E.M.V. Hoek, Preparation and characterization of membranes formed by nonsolvent induced phase separation: A review, Ind. Eng. Chem. Res. 50 (7) (2011) 3798-3817.
[17] S. Kawahito, T. Motomura, J. Glueck, Y. Nose, Development of a new hollow fiber silicone membrane oxygenator for ECMO: The recent progress, Ann. Thorac. Cardiovasc. Surg. 8 (5) (2002) 268-274.
[18] X.Y. Hong, J. Xiong, Z.C. Feng, Y. Shi, Extracorporeal membrane oxygenation (ECMO): Does it have a role in the treatment of severe COVID-19? Int. J. Infect. Dis. 94 (2020) 78-80.
[19] C.L. Huang, Y.M. Wang, X.W. Li, L. Ren, J.P. Zhao, Y. Hu, L. Zhang, G.H. Fan, J.Y. Xu, X.Y. Gu, Z.S. Cheng, T. Yu, J.A. Xia, Y. Wei, W.J. Wu, X.L. Xie, W. Yin, H. Li, M. Liu, Y. Xiao, H. Gao, L. Guo, J.G. Xie, G.F. Wang, R. Jiang, Z.C. Gao, Q. Jin, J.W. Wang, B. Cao, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet Lond. Engl. 395 (2020) 497-506.
[20] D.W. Wang, B. Hu, C. Hu, F.F. Zhu, X. Liu, J. Zhang, B.B. Wang, H. Xiang, Z.S. Cheng, Y. Xiong, Y. Zhao, Y.R. Li, X.H. Wang, Z.Y. Peng, Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China, JAMA 323 (11) (2020) 1061-1069.
[21] R.H. Bartlett, Extracorporeal life support in the management of severe respiratory failure, Clin. Chest Med. 21 (3) (2000) 555-561.
[22] A.J. Michaels, R.J. Schriener, S. Kolla, S.S. Awad, P.B. Rich, C. Reickert, J. Younger, R.B. Hirschl, R.H. Bartlett, Extracorporeal life support in pulmonary failure after trauma, J. Trauma 46 (4) (1999) 638-645.
[23] S. Kato, S. Morimoto, S. Hiramitsu, M. Nomura, T. Ito, H. Hishida, Use of percutaneous cardiopulmonary support of patients with fulminant myocarditis and cardiogenic shock for improving prognosis, Am. J. Cardiol. 83 (4) (1999) 623-625, A10.
[24] M.R. Hemmila, S.A. Rowe, T.N. Boules, J. Miskulin, J.W. McGillicuddy, D.J. Schuerer, J.W. Haft, F. Swaniker, S. Arbabi, R.B. Hirschl, R.H. Bartlett, Extracorporeal life support for severe acute respiratory distress syndrome in adults, Ann. Surg. 240 (4) (2004) 595-605.
[25] L. Gattinoni, A. Pesenti, D. Mascheroni, R. Marcolin, R. Fumagalli, F. Rossi, G. Iapichino, G. Romagnoli, L. Uziel, A. Agostoni, Low-frequency positive-pressure ventilation with extracorporeal CO₂ removal in severe acute respiratory failure, JAMA 256 (7) (1986) 881-886.
[26] S.H. Ye, D.T. Arazawa, Y. Zhu, V. Shankarraman, A.D. Malkin, J.D. Kimmel, L.J. Gamble, K. Ishihara, W.J. Federspiel, W.R. Wagner, Hollow fiber membrane modification with functional zwitterionic macromolecules for improved thromboresistance in artificial lungs, Langmuir 31 (8) (2015) 2463-2471.
[27] D.R. Lloyd, K.E. Kinzer, H.S. Tseng, Microporous membrane formation via thermally induced phase separation. I. Solid-liquid phase separation, J. Membr. Sci. 52 (3) (1990) 239-261.
[28] M.H. Nematollahi, A.H.S. Dehaghani, R. Abedini, CO₂/CH₄ separation with poly(4-methyl-1-pentyne) (TPX) based mixed matrix membrane filled with Al₂O₃ nanoparticles, Korean J. Chem. Eng. 33 (2) (2016) 657-665.
[29] M.B. Johnson, G.L. Wilkes, Microporous membranes of isotactic poly(4-methyl-1-pentene) from a melt-extrusion process. I. Effects of resin variables and extrusion conditions, J. Appl. Polym. Sci. 83 (10) (2002) 2095-2113.
[30] M.B. Johnson, G.L. Wilkes, Microporous membranes of isotactic poly(4-methyl-1-pentene) from a melt-extrusion process. II. Effects of thermal annealing and stretching on porosity, J. Appl. Polym. Sci. 84 (5) (2002) 1076-1100.
[31] V.V. Teplyakov, Diffusion of C1-C3 alkanes in semicrystalline poly(4-methyl-1-pentene) as a two-phase polymeric system, Int. J. Membr. Sci. Technol. 4 (1) (2017) 28-36.
[32] H. Yoshimizu, H. Fukatsu, T. Suzuki, Y. Tsujita, T. Kinoshita, CO₂ permeation and diffusion properties of semicrystalline poly(4-methyl pentene-1) membranes, Polym. J. 30 (12) (1998) 981-984.
[33] Q. Zhang, Y.Q. Zhang, D.W. Xia, Y. Zhao, Y.Q. Shi, Q.Z. Jiao, Preparation of a porous structure in a poly(4-methyl-1-pentene)/diphenyl ether system with a thermally induced phase-separation method, J. Appl. Polym. Sci. 112 (3) (2009) 1271-1277.
[34] H.J. Tao, J. Zhang, X.L. Wang, J.L. Gao, Phase separation and polymer crystallization in a poly(4-methyl-1-pentene)-dioctylsebacate-dimethylphthalate system via thermally induced phase separation, J. Polym. Sci. Part B Polym. Phys. 45 (2) (2007) 153-161.
[35] H.J. Tao, J. Zhang, X.L. Wang, Effect of diluents on the crystallization behavior of poly(4-methyl-1-pentene) and membrane morphology via thermally induced phase separation, J. Appl. Polym. Sci. 108 (2) (2008) 1348-1355.
[36] M.W. Lim, The history of extracorporeal oxygenators, Anaesthesia 61 (10) (2006) 984-995.
[37] H.J. Cho, D.W. Kim, G.S. Kim, I.S. Jeong, Anticoagulation therapy during extracorporeal membrane oxygenator support in pediatric patients, Chonnam Med. J. 53 (2) (2017) 110-117.
[38] H.J. Tao, Q. Xia, S. Jun, J. Zhang, X. Wang, Solid-liquid phase separation of poly-4-methyl-1-pentene/diluent system via thermally induced phase separation, Desalin. Water Treat. 17 (1-3) (2010) 294-303.
[39] J.L. Wang, Z.K. Xu, Y.Y. Xu, Preparation of poly(4-methyl-1-pentene) asymmetric or microporous hollow-fiber membranes by melt-spun and cold-stretch method, J. Appl. Polym. Sci. 100 (3) (2006) 2131-2141.
[40] Z.Y. Cui, C.H. Du, Y.Y. Xu, G.L. Ji, B.K. Zhu, Preparation of porous PVdF membrane via thermally induced phase separation using sulfolane, J. Appl. Polym. Sci. 108 (1) (2008) 272-280.
[41] X.Y. Wang, L. Zhang, D.H. Sun, Q.F. An, H.L. Chen, Effect of coagulation bath temperature on formation mechanism of poly(vinylidene fluoride) membrane, J. Appl. Polym. Sci. 110 (3) (2008) 1656-1663.
[42] S. Wongchitphimon, R. Wang, R. Jiraratananon, L. Shi, C.H. Loh, Effect of polyethylene glycol (PEG) as an additive on the fabrication of polyvinylidene fluoride-co-hexafluropropylene (PVDF-HFP) asymmetric microporous hollow fiber membranes, J. Membr. Sci. 369 (1-2) (2011) 329-338.
[43] A. Nakajima, S. Hayashi, T. Taka, Melting behavior of poly-4-methyl-pentene-1 single crystals, Kolloid Z. Und Z. Fur Polym. 233 (1) (1969) 869-878.
[44] F.J. Medellin-Rodriguez, P.J. Phillips, J.S. Lin, R. Campos, The triple melting behavior of poly(ethylene terephthalate): Molecular weight effects, J. Polym. Sci. B Polym. Phys. 35 (11) (1997) 1757-1774.
[45] F.J. Medellin-Rodriguez, P.J. Phillips, J.S. Lin, C.A. Avila-Orta, Triple melting behavior of poly(ethylene terephthalateco-1, 4-cyclohexylene dimethylene terephthalate) random copolyesters, J. Polym. Sci. B Polym. Phys. 36 (5) (1998) 763-781.
[46] S.S. Kim, G.B.A. Lim, A.A. Alwattari, Y.F. Wang, D.R. Lloyd, Microporous membrane formation via thermally-induced phase separation. V. Effect of diluent mobility and crystallization on the structure of isotactic polypropylene membranes, J. Membr. Sci. 64 (1-2) (1991) 41-53.
[47] S.S. Kim, D.R. Lloyd, Microporous membrane formation via thermally-induced phase separation. III. Effect of thermodynamic interactions on the structure of isotactic polypropylene membranes, J. Membr. Sci. 64 (1-2) (1991) 13-29.
[48] O.O. Teber, A.D. Altinay, S.A.N. Mehrabani, R.S. Tasdemir, B. Zeytuncu, E.A. Genceli, E. Dulekgurgen, K. Pekkan, I. Koyuncu, Polymeric hollow fiber membrane oxygenators as artificial lungs: A review, Biochem. Eng. J. 180 (2022) 108340.
[49] G.B.A. Lim, S.S. Kim, Q.H. Ye, Y.F. Wang, D.R. Lloyd, Microporous membrane formation via thermally-induced phase separation. IV. Effect of isotactic polypropylene crystallization kinetics on membrane structure, J. Membr. Sci. 64 (1-2) (1991) 31-40.
[50] M. Fukuda, Evolutions of extracorporeal membrane oxygenator (ECMO): Perspectives for advanced hollow fiber membrane, J. Artif. Organs 27 (1) (2024) 1-6.
[51] Y.H. Tang, M.F. Li, Y.K. Lin, L. Wang, F.Y. Wu, X.L. Wang, A novel green diluent for the preparation of poly(4-methyl-1-pentene) membranes via a thermally-induced phase separation method, Membranes 11 (8) (2021) 622.
[52] T.Q. Zhang, S. Hao, J. Xiao, Z.Q. Jia, Preparation of poly(4-methyl-1-pentene) membranes by low-temperature thermally induced phase separation, ACS Appl. Polym. Mater. 5 (3) (2023) 1998-2005.
[53] F.C. Lin, D.M. Wang, J.Y. Lai, Asymmetric TPX membranes with high gas flux, J. Membr. Sci. 110 (1) (1996) 25-36.
[54] J.Y. Lai, S.L. Wei, Preparation of vinylpyridine irradiation-grafted poly(4-methyl-pentene-1) membrane for oxygen enrichment, J. Appl. Polym. Sci. 32 (7) (1986) 5763-5775.
[55] J.Y. Lai, G.J. Wu, S.S. Shyu, TPX/siloxane blend membrane for oxygen enrichment, J. Appl. Polym. Sci. 34 (2) (1987) 559-569.
[56] Y. Wang, Y. Liu, Q. Han, H. Lin, F. Liu, A novel poly (4-methyl-1-pentene)/polypropylene (PMP/PP) thin film composite (TFC) artificial lung membrane for enhanced gas transport and excellent hemo-compatibility, J. Membr. Sci. 649 (2022) 120359.
[57] Z.M.H. Mohd Shafie, A.L. Ahmad, S. Rode, B. Belaissaoui, D. Roizard, S.C. Low, Prospect of oxyplus hollow fibre membrane with dense polymethylpentene (PMP) skin as support-gutter layer of thin film composite (TFC) for biogas upgrading, J. Phys. Sci. 30 (Supp.2) (2019) 179-189.
[58] R. Abedini, A. Mosayebi, M. Mokhtari, Improved CO₂ separation of azide cross-linked PMP mixed matrix membrane embedded by nano-CuBTC metal organic framework, Process. Saf. Environ. Prot. 114 (2018) 229-239.
[59] M.H. Nematollahi, A.H.S. Dehaghani, V. Pirouzfar, E. Akhondi, Mixed matrix membranes comprising PMP polymer with dispersed alumina nanoparticle fillers to separate CO₂/N₂, Macromol. Res. 24 (9) (2016) 782-792.

Investigation on the synthesis conditions of poly(4-methyl-1-pentene) hollow fiber membrane with high gas permeability and strong tensile strength

Investigation on the synthesis conditions of poly(4-methyl-1-pentene) hollow fiber membrane with high gas permeability and strong tensile strength

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 6

编辑推荐

Metrics

本文评价

[1]	Xiaozu Wang, Xiaogang Li, Juan Yue, Yangming Cheng, Ke Xu, Qian Wang, Fan Fan, Zhaohui Wang, Zhaoliang Cui. Fabrication of poly(vinylidene fluoride) membrane via thermally induced phase separation using ionic liquid as green diluent[J]. 中国化学工程学报, 2020, 28(5): 1415-1423.
[2]	Na Tang, Xinxin Hua, Zhao Li, Lei Zhang, Jiating Wang, Jun Xiang, Penggao Cheng, Xuekui Wang. Effect of ethylene vinyl acetate content on the performance of VMD using HDPE co-blending membrane[J]. 中国化学工程学报, 2019, 27(5): 1058-1066.
[3]	Zhensheng Yang, Zheng Sun, Dongsheng Cui, Pingli Li, Zhiying Wang. TIPS behavior for IPP/nano-SiO₂ blend membrane formation and its contribution to membrane morphology and performance[J]. Chinese Journal of Chemical Engineering, 2019, 27(2): 467-475.
[4]	邱运仁, 松山秀人, 钟宏, 叶红齐, 黄可龙. Effects of F127 on Properties of PVB/F127 Blend Hollow Fiber Membrane via Thermally Induced Phase Separation[J]. , 2010, 18(2): 207-216.
[5]	杨振生,李凭力, 常贺英, 王世昌. 热致相分离法iPP中空纤维微空膜结构与性能——稀释剂的作用[J]. , 2006, 14(3): 394-397.
[6]	张秀莉, 张卫东, 郝新敏, 张慧峰, 张泽廷, 张建春. PTFE多孔膜气体渗透数学模型和膜孔结构的影响[J]. , 2003, 11(4): 383-387.