Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide

›› 2011, Vol. 19 ›› Issue (4): 558-564.

Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide

罗宁¹, 卢英妹², 江燕斌^1,2

1. Star Lake Bioscience Co., Inc., Zhaoqing 526040, China;
2. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China

收稿日期:2011-05-05 修回日期:2011-06-08 出版日期:2011-08-28 发布日期:2011-08-28
通讯作者: JIANG Yanbin,E-mail:cebjiang@scut.edu.cn
基金资助:
Supported by the National Natural Science Foundation of China (21076084, 20676046);the Fundamental Research Funds for the Central Universities (2011ZZ0006)

Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide

LUO Nin¹, LU Yingmei², JIANG Yanbin^1,2

1. Star Lake Bioscience Co., Inc., Zhaoqing 526040, China;
2. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China

Received:2011-05-05 Revised:2011-06-08 Online:2011-08-28 Published:2011-08-28
Supported by:
Supported by the National Natural Science Foundation of China (21076084, 20676046);the Fundamental Research Funds for the Central Universities (2011ZZ0006)

摘要/Abstract

摘要： Phase behavior of paclitaxel in solvent mixtures of dichloromethane and supercritical carbon dioxide was investigated using a supercritical phase monitor.Cloud point pressures were determined as a function of temperature, pressure and paclitaxel content from 313.1 to 343.1K and pressures up to 33.52 MPa.The ternary mixtures exhibit a typical lower critical solution temperature behavior.When paclitaxel content increases, the single-phase region shrinks in size.Three cubic equations of state(Redlich-Kworng, Soave-Redlich-Kwong and Peng-Robinson equation of state) coupled with the van der Waals one-fluid mixing rules were selected to correlate the experimental data.The results indicate that SRK EOS coupled with two binary interaction parameters k_ij and l_ij can predict paclitaxel solubility for the best fit of experimental data.

关键词: supercritical CO₂, paclitaxel, dichloromethane, solubility, data correlation

Abstract: Phase behavior of paclitaxel in solvent mixtures of dichloromethane and supercritical carbon dioxide was investigated using a supercritical phase monitor.Cloud point pressures were determined as a function of temperature, pressure and paclitaxel content from 313.1 to 343.1K and pressures up to 33.52 MPa.The ternary mixtures exhibit a typical lower critical solution temperature behavior.When paclitaxel content increases, the single-phase region shrinks in size.Three cubic equations of state(Redlich-Kworng, Soave-Redlich-Kwong and Peng-Robinson equation of state) coupled with the van der Waals one-fluid mixing rules were selected to correlate the experimental data.The results indicate that SRK EOS coupled with two binary interaction parameters k_ij and l_ij can predict paclitaxel solubility for the best fit of experimental data.

Key words: supercritical CO₂, paclitaxel, dichloromethane, solubility, data correlation

罗宁, 卢英妹, 江燕斌. Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide [J]. , 2011, 19(4): 558-564.

LUO Nin, LU Yingmei, JIANG Yanbin. Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide [J]. , 2011, 19(4): 558-564.

参考文献

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Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide

Solubility of Paclitaxel in Mixtures of Dichloromethane and Supercritical Carbon Dioxide

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