Determination of metastable zone and induction time of analgin for cooling crystallization

doi:10.1016/j.cjche.2016.05.046

›› 2017, Vol. 25 ›› Issue (3): 313-318.DOI: 10.1016/j.cjche.2016.05.046

• Chemical Engineering Thermodynamics • Previous Articles Next Articles

Determination of metastable zone and induction time of analgin for cooling crystallization

Ling Zhou¹, ZhaoWang^1,2, Meijing Zhang^1,2, Mingxia Guo¹, Shijie Xu¹, Qiuxiang Yin^1,2

1 School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China;
2 Collaborative Innovation Center of Chemical Science and Chemical Engineering, Tianjin 300072, China

Received:2016-04-15 Revised:2016-05-30 Online:2017-04-15 Published:2017-03-28
Supported by:
Supported by theNational Natural Science Foundation of China (21206109) and China Ministry of Science and Major National Scientific Instrument Development Project (21527812).

Determination of metastable zone and induction time of analgin for cooling crystallization

Ling Zhou¹, Zhao Wang^1,2, Meijing Zhang^1,2, Mingxia Guo¹, Shijie Xu¹, Qiuxiang Yin^1,2

1 School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China;
2 Collaborative Innovation Center of Chemical Science and Chemical Engineering, Tianjin 300072, China

通讯作者: Qiuxiang Yin
基金资助:
Supported by theNational Natural Science Foundation of China (21206109) and China Ministry of Science and Major National Scientific Instrument Development Project (21527812).

Abstract

Abstract: The solubility, metastable zone width, and induction time of analgin for unseeded batch cooling crystallization in ethanol-aqueous system were experimentally determined. The solubility data could be well described by the van't Hoff equation model. The metastable zone width at various cooling rates was measured, and some parameters of nucleation kinetic were calculated using the Ny'vlt theory. Furthermore, the induction period of various temperatures and supersaturation ratios was also measured. According to classical nucleation theory, some nucleation parameters and interfacial energy was calculated through the induction time (t_ind) data. Homogeneous nucleation tended to occurwhen the supersaturation is high, whereas heterogeneous nucleationwasmore likely to occur when the supersaturation is low.

Key words: Analgin, Cooling crystallization, Primary nucleation, Metastable zone, Induction time

摘要： The solubility, metastable zone width, and induction time of analgin for unseeded batch cooling crystallization in ethanol-aqueous system were experimentally determined. The solubility data could be well described by the van't Hoff equation model. The metastable zone width at various cooling rates was measured, and some parameters of nucleation kinetic were calculated using the Ny'vlt theory. Furthermore, the induction period of various temperatures and supersaturation ratios was also measured. According to classical nucleation theory, some nucleation parameters and interfacial energy was calculated through the induction time (t_ind) data. Homogeneous nucleation tended to occurwhen the supersaturation is high, whereas heterogeneous nucleationwasmore likely to occur when the supersaturation is low.

关键词: Analgin, Cooling crystallization, Primary nucleation, Metastable zone, Induction time

Ling Zhou, ZhaoWang, Meijing Zhang, Mingxia Guo, Shijie Xu, Qiuxiang Yin. Determination of metastable zone and induction time of analgin for cooling crystallization[J]. , 2017, 25(3): 313-318.

Ling Zhou, Zhao Wang, Meijing Zhang, Mingxia Guo, Shijie Xu, Qiuxiang Yin. Determination of metastable zone and induction time of analgin for cooling crystallization[J]. , 2017, 25(3): 313-318.

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Determination of metastable zone and induction time of analgin for cooling crystallization

Determination of metastable zone and induction time of analgin for cooling crystallization

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