Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy

doi:10.1016/j.cjche.2020.07.063

Chinese Journal of Chemical Engineering ›› 2021, Vol. 29 ›› Issue (1): 426-436.DOI: 10.1016/j.cjche.2020.07.063

• Materials and Product Engineering • Previous Articles

Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy

Chaobo Song¹, Jiapeng Zhang¹, Shuang Li², Shengbin Yang³, Eryi Lu², Zhenhao Xi¹, Lian Cen¹, Ling Zhao¹, Weikang Yuan¹

1 State Key Laboratory of Chemical Engineering, School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China;
2 Department of Stomatology of Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China;
3 Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639, Zhizaoju Road, Shanghai 200011, China

Received:2020-05-21 Revised:2020-06-21 Online:2021-04-02 Published:2021-01-28
Contact: Eryi Lu, Zhenhao Xi
Supported by:
The authors appreciate the experimental support and suggestion from Department of Stomatology of Renji Hospital, and the discussion with Dr.Xun P from Flinders Institute for NanoScale Science & Technology at Flinders University. The authors are grateful to the National Natural Science Foundation of China (Grant No. 21676083), the Fundamental Research Funds for the Central Universities and 111 Project (Grant No. B20031).

Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy

Chaobo Song¹, Jiapeng Zhang¹, Shuang Li², Shengbin Yang³, Eryi Lu², Zhenhao Xi¹, Lian Cen¹, Ling Zhao¹, Weikang Yuan¹

1 State Key Laboratory of Chemical Engineering, School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China;
2 Department of Stomatology of Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China;
3 Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639, Zhizaoju Road, Shanghai 200011, China

通讯作者: Eryi Lu, Zhenhao Xi
基金资助:
The authors appreciate the experimental support and suggestion from Department of Stomatology of Renji Hospital, and the discussion with Dr.Xun P from Flinders Institute for NanoScale Science & Technology at Flinders University. The authors are grateful to the National Natural Science Foundation of China (Grant No. 21676083), the Fundamental Research Funds for the Central Universities and 111 Project (Grant No. B20031).

Abstract

Abstract: In this study, mesoporous bioactive glass particles (MBGs) are incorporated into poly(lactic-co-glycolic acid) (PLGA) to fabricate highly interconnected macroporous composite scaffolds with enhanced mechanical and biological properties via a developed supercritical carbon dioxide (scCO₂) foaming method. Scaffolds show favorable highly interconnected and macroporous structure through a high foaming pressure and long venting time foaming strategy. Specifically, scaffolds with porosity from 73% to 85%, pore size from 120 μm to 320 μm and interconnectivity of over 95% are controllably fabricated at MBG content from 0 wt% to 20 wt%. In comparison with neat PLGA scaffolds, composite scaffolds perform improved strength (up to 1.5 folds) and Young's modulus (up to 3 folds). The interconnected macroporous structure is beneficial to the ingrowth of cells. More importantly, composite scaffolds also provide a more promising microenvironment for cellular proliferation and adhesion with the release of bioactive ions. Hopefully, MBG/PLGA scaffolds developed by the green foaming strategy in this work show promising morphological, mechanical and biological features for tissue regeneration.

Key words: Scaffold, Mesoporous bioactive glass, Supercritical carbon dioxide, Foaming, Poly(lactic-co-glycolic acid)

摘要： In this study, mesoporous bioactive glass particles (MBGs) are incorporated into poly(lactic-co-glycolic acid) (PLGA) to fabricate highly interconnected macroporous composite scaffolds with enhanced mechanical and biological properties via a developed supercritical carbon dioxide (scCO₂) foaming method. Scaffolds show favorable highly interconnected and macroporous structure through a high foaming pressure and long venting time foaming strategy. Specifically, scaffolds with porosity from 73% to 85%, pore size from 120 μm to 320 μm and interconnectivity of over 95% are controllably fabricated at MBG content from 0 wt% to 20 wt%. In comparison with neat PLGA scaffolds, composite scaffolds perform improved strength (up to 1.5 folds) and Young's modulus (up to 3 folds). The interconnected macroporous structure is beneficial to the ingrowth of cells. More importantly, composite scaffolds also provide a more promising microenvironment for cellular proliferation and adhesion with the release of bioactive ions. Hopefully, MBG/PLGA scaffolds developed by the green foaming strategy in this work show promising morphological, mechanical and biological features for tissue regeneration.

关键词: Scaffold, Mesoporous bioactive glass, Supercritical carbon dioxide, Foaming, Poly(lactic-co-glycolic acid)

Chaobo Song, Jiapeng Zhang, Shuang Li, Shengbin Yang, Eryi Lu, Zhenhao Xi, Lian Cen, Ling Zhao, Weikang Yuan. Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy[J]. Chinese Journal of Chemical Engineering, 2021, 29(1): 426-436.

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Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy

Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy

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