Preparation and Analysis of Fe3O4 Magnetic Nanoparticles Used as Targeted-drug Carriers

Abstract

Abstract: Fe₃O₄ magnetic nanoparticles were prepared by the aqueous co-precipitation of FeCl₃·6H₂O and FeCl₂·4H₂O with addition of ammonium hydroxide.The conditions for the preparation of Fe₃O₄ magnetic nanoparticles were optimized,and Fe₃O₄ magnetic nanoparticles obtained were characterized systematically by means of transmission electron microscope(TEM),dynamic laser scattering analyzer(DLS)and X-ray diffraction(XRD). The results revealed that the magnetic nanoparticles were cubic shaped and dispersive,with narrow size distribution and average diameter of 11.4 nm.It was found that the homogeneous variation of pH value in the solution via the control on the dropping rate of aqueous ammonia played a critical role in size distribution.The magnetic response of the product in the magnetic field was also analyzed and evaluated carefully.A 32.6 mT magnetic field which is produced by four ferromagnets was found to be sufficient to excite the dipole moments of 0.05 g Fe₃O₄ powder 2 cm far away from the ferromagnets.In conclusion,the Fe₃O₄ magnetic nanoparticles with excellent properties were competent for the magnetic carriers of targeted-drug in future application.

Key words: targeted-drug, Fe₃O₄, magnetic particle, nanometre

摘要： Fe₃O₄ magnetic nanoparticles were prepared by the aqueous co-precipitation of FeCl₃·6H₂O and FeCl₂·4H₂O with addition of ammonium hydroxide.The conditions for the preparation of Fe₃O₄ magnetic nanoparticles were optimized,and Fe₃O₄ magnetic nanoparticles obtained were characterized systematically by means of transmission electron microscope(TEM),dynamic laser scattering analyzer(DLS)and X-ray diffraction(XRD). The results revealed that the magnetic nanoparticles were cubic shaped and dispersive,with narrow size distribution and average diameter of 11.4 nm.It was found that the homogeneous variation of pH value in the solution via the control on the dropping rate of aqueous ammonia played a critical role in size distribution.The magnetic response of the product in the magnetic field was also analyzed and evaluated carefully.A 32.6 mT magnetic field which is produced by four ferromagnets was found to be sufficient to excite the dipole moments of 0.05 g Fe₃O₄ powder 2 cm far away from the ferromagnets.In conclusion,the Fe₃O₄ magnetic nanoparticles with excellent properties were competent for the magnetic carriers of targeted-drug in future application.

关键词: targeted-drug, Fe₃O₄, magnetic particle, nanometre

ZHAO Yuanbi, QIU Zumin, HUANG Jiaying. Preparation and Analysis of Fe₃O₄ Magnetic Nanoparticles Used as Targeted-drug Carriers[J]. , 2008, 16(3): 451-455.

赵原壁, 邱祖民, 黄佳英. Preparation and Analysis of Fe₃O₄ Magnetic Nanoparticles Used as Targeted-drug Carriers[J]. , 2008, 16(3): 451-455.

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Preparation and Analysis of Fe₃O₄ Magnetic Nanoparticles Used as Targeted-drug Carriers

Preparation and Analysis of Fe₃O₄ Magnetic Nanoparticles Used as Targeted-drug Carriers

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