Effect of Temperature on Volumetric and Viscometric Properties of Homologous Amino Acids in Aqueous Solutions of Metformin Hydrochloride

Abstract

Abstract: Density(ρ)and viscosity(η)are measured for glycine,DL-α-alanine DL-α-valine,and DL-α-leucine in 0.05,0.10,0.15 and 0.20 mol·L^-1 aqueous metformin hydrochloride at 308.15,313.15 and 318.15 K.The measured values are used to estimate some important parameters,such as partial molal volume V_φ,standard partial molal volume V_φ⁰,transfer volume ΔV_φ⁰,hydration number n_H,the second derivative of infinite dilution of partial molal volume with respect to temperature,viz.,∂²V_φ⁰/∂T²,viscosity B-coefficient,variation of B with temperature,viz., dB/dT,free energy of activation per mole of solvent Δμ₁⁰ and solute Δμ₂⁰ of the amino acids.These parameters are interpreted in terms of solute-solute and solute-solvent interactions and structure making/breaking ability of solutes in the given solution.In addition,V_φ⁰, ΔV_φ⁰,viscosity B-coefficient,ΔB and Δμ₂⁰ are split into group contributions(NH₃⁺COO^-)and —CH₂ of the amino acids using their linear correlation and their behavior is discussed.

Key words: standard partial molal volume, transfer volume, hydration number, viscosity B-coefficient, activation energy, metformin hydrochloride

摘要： Density(ρ)and viscosity(η)are measured for glycine,DL-α-alanine DL-α-valine,and DL-α-leucine in 0.05,0.10,0.15 and 0.20 mol·L^-1 aqueous metformin hydrochloride at 308.15,313.15 and 318.15 K.The measured values are used to estimate some important parameters,such as partial molal volume V_φ,standard partial molal volume V_φ⁰,transfer volume ΔV_φ⁰,hydration number n_H,the second derivative of infinite dilution of partial molal volume with respect to temperature,viz.,∂²V_φ⁰/∂T²,viscosity B-coefficient,variation of B with temperature,viz., dB/dT,free energy of activation per mole of solvent Δμ₁⁰ and solute Δμ₂⁰ of the amino acids.These parameters are interpreted in terms of solute-solute and solute-solvent interactions and structure making/breaking ability of solutes in the given solution.In addition,V_φ⁰, ΔV_φ⁰,viscosity B-coefficient,ΔB and Δμ₂⁰ are split into group contributions(NH₃⁺COO^-)and —CH₂ of the amino acids using their linear correlation and their behavior is discussed.

关键词: standard partial molal volume, transfer volume, hydration number, viscosity B-coefficient, activation energy, metformin hydrochloride

K. Rajagopal, S. S. Jayabalakrishnan. Effect of Temperature on Volumetric and Viscometric Properties of Homologous Amino Acids in Aqueous Solutions of Metformin Hydrochloride[J]. , 2010, 18(3): 425-445.

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