Hydrolysis Kinetics of 2-Pyridinecarboxamide, 3-Pyridinecarboxamide and 4-Pyridinecarboxamide in High-Temperature Water

doi:10.1016/j.cjche.2014.06.024

›› 2014, Vol. 22 ›› Issue (9): 1005-1008.DOI: 10.1016/j.cjche.2014.06.024

• CATALYSIS, KINETICS AND REACTION ENGINEERING • Previous Articles Next Articles

Hydrolysis Kinetics of 2-Pyridinecarboxamide, 3-Pyridinecarboxamide and 4-Pyridinecarboxamide in High-Temperature Water

Jie Fu¹, Haoming Ren¹, Ju Zhu², Xiuyang Lu¹

1 Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China;
2 School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China

Received:2012-11-30 Revised:2013-04-01 Online:2014-11-04 Published:2014-09-28
Supported by:
Supported by the National Natural Science Foundation of China (21176218), and Zhejiang Key Innovation Team of Green Pharmaceutical Technology (2010R50043).

Hydrolysis Kinetics of 2-Pyridinecarboxamide, 3-Pyridinecarboxamide and 4-Pyridinecarboxamide in High-Temperature Water

Jie Fu¹, Haoming Ren¹, Ju Zhu², Xiuyang Lu¹

1 Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China;
2 School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China

通讯作者: Xiuyang Lu
基金资助:
Supported by the National Natural Science Foundation of China (21176218), and Zhejiang Key Innovation Team of Green Pharmaceutical Technology (2010R50043).

Abstract

Abstract: A kinetic study is reported here on hydrolysis of three pyridinecarboxamides in high-temperature water in the temperature range of 190-250℃ at 8 MPa. 2-Pyridinecarboxamide, 3-pyridinecarboxamide and 4-pyridinecarboxamide hydrolyze to corresponding picolinic acids. 2-Picolinic acid is further decarboxylated to pyridine. Experiments at different temperatures show that the first-order rate constants display an Arrhenius behavior with activation energies of (110.9 ± 2.3), (70.4 ± 2.1) and (61.4 ± 1.8) kJ·mol^-1 for 2-pyridinecarboxamide, 3-pyridinecarboxamide and 4-pyridinecarboxamide, respectively. These kinetic parameters for pyridinecarboxamide hydrolysis are more reliable and accurate than those from the consecutive hydrolysis of cyanopyridines.

Key words: High-temperature water, Hydrolysis, Pyridinecarboxamide, Kinetics, Activation energy

摘要： A kinetic study is reported here on hydrolysis of three pyridinecarboxamides in high-temperature water in the temperature range of 190-250℃ at 8 MPa. 2-Pyridinecarboxamide, 3-pyridinecarboxamide and 4-pyridinecarboxamide hydrolyze to corresponding picolinic acids. 2-Picolinic acid is further decarboxylated to pyridine. Experiments at different temperatures show that the first-order rate constants display an Arrhenius behavior with activation energies of (110.9 ± 2.3), (70.4 ± 2.1) and (61.4 ± 1.8) kJ·mol^-1 for 2-pyridinecarboxamide, 3-pyridinecarboxamide and 4-pyridinecarboxamide, respectively. These kinetic parameters for pyridinecarboxamide hydrolysis are more reliable and accurate than those from the consecutive hydrolysis of cyanopyridines.

关键词: High-temperature water, Hydrolysis, Pyridinecarboxamide, Kinetics, Activation energy

Jie Fu, Haoming Ren, Ju Zhu, Xiuyang Lu. Hydrolysis Kinetics of 2-Pyridinecarboxamide, 3-Pyridinecarboxamide and 4-Pyridinecarboxamide in High-Temperature Water[J]. , 2014, 22(9): 1005-1008.

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Hydrolysis Kinetics of 2-Pyridinecarboxamide, 3-Pyridinecarboxamide and 4-Pyridinecarboxamide in High-Temperature Water

Hydrolysis Kinetics of 2-Pyridinecarboxamide, 3-Pyridinecarboxamide and 4-Pyridinecarboxamide in High-Temperature Water

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