Intelligent chemical synthesis based on microchemical engineering technology

doi:10.1016/j.cjche.2025.05.010

Abstract

Abstract: Chemical synthesis is essential in industries such as petrochemicals, fine chemicals, and pharmaceuticals, driving economic and social development. The increasing demand for new molecules and materials calls for novel chemical reactions; however, manual experimental screening is time-consuming. Artificial intelligence (AI) offers a promising solution by leveraging large-scale experimental data to model chemical reactions, although challenges such as the lack of standardization and predictability in chemical synthesis hinder AI applications. Additionally, the multi-scale nature of chemical reactions, along with complex multiphase processes, further complicates the task. Recent advances in microchemical systems, particularly continuous flow methods using microreactors, provide precise control over reaction conditions, enhancing reproducibility and enabling high-throughput experimentation. These systems minimize transport-related inconsistencies and facilitate scalable industrial applications. This review systematically explores recent developments in intelligent synthesis based on microchemical systems, focusing on reaction system design, synthesis robots, closed-loop optimization, and high-throughput experimentation, while identifying key areas for future research.

Key words: Flow chemistry, Microreactor, Microfluidics, Machine learning, Multi-phase disperse

摘要： Chemical synthesis is essential in industries such as petrochemicals, fine chemicals, and pharmaceuticals, driving economic and social development. The increasing demand for new molecules and materials calls for novel chemical reactions; however, manual experimental screening is time-consuming. Artificial intelligence (AI) offers a promising solution by leveraging large-scale experimental data to model chemical reactions, although challenges such as the lack of standardization and predictability in chemical synthesis hinder AI applications. Additionally, the multi-scale nature of chemical reactions, along with complex multiphase processes, further complicates the task. Recent advances in microchemical systems, particularly continuous flow methods using microreactors, provide precise control over reaction conditions, enhancing reproducibility and enabling high-throughput experimentation. These systems minimize transport-related inconsistencies and facilitate scalable industrial applications. This review systematically explores recent developments in intelligent synthesis based on microchemical systems, focusing on reaction system design, synthesis robots, closed-loop optimization, and high-throughput experimentation, while identifying key areas for future research.

关键词: Flow chemistry, Microreactor, Microfluidics, Machine learning, Multi-phase disperse

Yongqi Pan, Yazi Yu, Lijie Wang, Guogang Hu, Yujun Wang, Guangsheng Luo. Intelligent chemical synthesis based on microchemical engineering technology[J]. Chinese Journal of Chemical Engineering, 2025, 84(8): 274-288.

Yongqi Pan, Yazi Yu, Lijie Wang, Guogang Hu, Yujun Wang, Guangsheng Luo. Intelligent chemical synthesis based on microchemical engineering technology[J]. 中国化学工程学报, 2025, 84(8): 274-288.

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