Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains

doi:10.1016/j.cjche.2020.12.004

Abstract

Abstract: The production capability of a fermentation process is predominately determined by individual strains, which ultimately affected ultimately by interactions between the scale-dependent flow field developed within bioreactors and the physiological response of these strains. Interpreting these complicated interactions is key for better understanding the scale-up of the fermentation process. We review these two aspects and address progress in strategies for scaling up fermentation processes. A perspective on how to incorporate the multiomics big data into the scale-up strategy is presented to improve the design and operation of industrial fermentation processes.

Key words: Fermentation, Scale-up, Bioreactors, Gas–liquid flow, Kinetics

摘要： The production capability of a fermentation process is predominately determined by individual strains, which ultimately affected ultimately by interactions between the scale-dependent flow field developed within bioreactors and the physiological response of these strains. Interpreting these complicated interactions is key for better understanding the scale-up of the fermentation process. We review these two aspects and address progress in strategies for scaling up fermentation processes. A perspective on how to incorporate the multiomics big data into the scale-up strategy is presented to improve the design and operation of industrial fermentation processes.

关键词: Fermentation, Scale-up, Bioreactors, Gas–liquid flow, Kinetics

Jianye Xia, Guan Wang, Meng Fan, Min Chen, Zeyu Wang, Yingping Zhuang. Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 178-184.

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