SCI和EI收录∣中国化工学会会刊

Chinese Journal of Chemical Engineering ›› 2023, Vol. 57 ›› Issue (5): 280-289.DOI: 10.1016/j.cjche.2022.09.019

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Physico-chemical parameters for the assembly of moxifloxacin hydrochloride and cetyltrimethylammonium chloride mixture in aqueous and alcoholic media

Arnop Dutta1, Md. Tuhinur R. Joy2, Sk. Md. Ali Ahsan1, Mansour K. Gatasheh3, Dileep Kumar4,5, Malik Abdul Rub6,7, Md. Anamul Hoque1, Mohammad Majibur Rahman8, Nasrul Hoda9, D.M. Shafiqul Islam1   

  1. 1. Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh;
    2. Department of Chemistry, Jashore University of Science and Technology, Jashore 7408, Bangladesh;
    3. Department of Biochemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;
    4. Laboratory for Chemical Computation and Modeling, Institute for Computational Science and Artificial Intelligence, Van Lang University, Ho Chi Minh City, Viet Nam;
    5. Faculty of Applied Technology, Van Lang University, Ho Chi Minh City, Viet Nam;
    6. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia;
    7. Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia;
    8. Department of Environmental Sciences, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh;
    9. Department of Neurology, Henry Ford Health System, Detroit, MI 48292, USA
  • Received:2022-05-29 Revised:2022-09-19 Online:2023-07-08 Published:2023-05-28
  • Contact: Dileep Kumar,E-mail:kumar.dileep@vlu.edu.vn
  • Supported by:
    This research work was funded by Institutional Fund Projects (IFPIP:515-961-1443).

Physico-chemical parameters for the assembly of moxifloxacin hydrochloride and cetyltrimethylammonium chloride mixture in aqueous and alcoholic media

Arnop Dutta1, Md. Tuhinur R. Joy2, Sk. Md. Ali Ahsan1, Mansour K. Gatasheh3, Dileep Kumar4,5, Malik Abdul Rub6,7, Md. Anamul Hoque1, Mohammad Majibur Rahman8, Nasrul Hoda9, D.M. Shafiqul Islam1   

  1. 1. Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh;
    2. Department of Chemistry, Jashore University of Science and Technology, Jashore 7408, Bangladesh;
    3. Department of Biochemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;
    4. Laboratory for Chemical Computation and Modeling, Institute for Computational Science and Artificial Intelligence, Van Lang University, Ho Chi Minh City, Viet Nam;
    5. Faculty of Applied Technology, Van Lang University, Ho Chi Minh City, Viet Nam;
    6. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia;
    7. Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia;
    8. Department of Environmental Sciences, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh;
    9. Department of Neurology, Henry Ford Health System, Detroit, MI 48292, USA
  • 通讯作者: Dileep Kumar,E-mail:kumar.dileep@vlu.edu.vn
  • 基金资助:
    This research work was funded by Institutional Fund Projects (IFPIP:515-961-1443).

Abstract: The aggregation behavior of the mixture of cetyltrimethylammonium chloride (CTAC), a cationic surfactant, and moxifloxacin hydrochloride (MFH), a fourth-generation fluoroquinolone antibiotic drug, has been studied using the conductivity technique in aqueous and alcoholic (EtOH, 1-PrOH, and 2-BuOH) media. The study was performed at several temperatures between 298.15 and 323.15 K at 5 K intervals. The assembly has been characterized by evaluating the micellar parameters, such as the critical micelle concentration (CMC) and the counter ion binding (β), of the CTAC + MFH mixture. The values of the CMC for the assembly of the CTAC + MFH mixture were reliant on the composition of alcohols in the mixed solvents and the temperature. The CMC values of the CTAC + MFH mixture increased with increasing temperature; that is, assembly was delayed by increased temperature. The micellization of the CTAC + MFH mixed system was delayed in alcoholic media. The observed -ΔGm0 values for the association of the CTAC + MFH mixed system demonstrated a spontaneous aggregation process under all study conditions. Based on the -ΔHm0 and -ΔSm0 values, the association of the CTAC + MFH mixture is exothermic and the interaction forces acting between the CTAC and MFH species are hydrophobic, ion–dipole, and electrostatic interactions. The transfer properties and enthalpy–entropy compensation were also assessed and described comprehensively.

Key words: Moxifloxacin hydrochloride drug, Aggregation, Alcohol, Hydrophobic interaction, Critical micelle concentration, Thermodynamic properties

摘要: The aggregation behavior of the mixture of cetyltrimethylammonium chloride (CTAC), a cationic surfactant, and moxifloxacin hydrochloride (MFH), a fourth-generation fluoroquinolone antibiotic drug, has been studied using the conductivity technique in aqueous and alcoholic (EtOH, 1-PrOH, and 2-BuOH) media. The study was performed at several temperatures between 298.15 and 323.15 K at 5 K intervals. The assembly has been characterized by evaluating the micellar parameters, such as the critical micelle concentration (CMC) and the counter ion binding (β), of the CTAC + MFH mixture. The values of the CMC for the assembly of the CTAC + MFH mixture were reliant on the composition of alcohols in the mixed solvents and the temperature. The CMC values of the CTAC + MFH mixture increased with increasing temperature; that is, assembly was delayed by increased temperature. The micellization of the CTAC + MFH mixed system was delayed in alcoholic media. The observed -ΔGm0 values for the association of the CTAC + MFH mixed system demonstrated a spontaneous aggregation process under all study conditions. Based on the -ΔHm0 and -ΔSm0 values, the association of the CTAC + MFH mixture is exothermic and the interaction forces acting between the CTAC and MFH species are hydrophobic, ion–dipole, and electrostatic interactions. The transfer properties and enthalpy–entropy compensation were also assessed and described comprehensively.

关键词: Moxifloxacin hydrochloride drug, Aggregation, Alcohol, Hydrophobic interaction, Critical micelle concentration, Thermodynamic properties