SCI和EI收录∣中国化工学会会刊

Chinese Journal of Chemical Engineering ›› 2015, Vol. 23 ›› Issue (5): 812-815.DOI: 10.1016/j.cjche.2014.03.006

• 化工热力学 • 上一篇    下一篇

Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15 K to 333.15 K

Md Khalid Anwer1, Faiyaz Shakeel2,3   

  1. 1 Department of Pharmaceutics, College of Pharmacy, Salman Bin Abdulaziz University, Al-Kharj, Saudi Arabia;
    2 Center of Excellence in Biotechnology Research, King Saud University, Riyadh 11451, Saudi Arabia;
    3 Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
  • 收稿日期:2014-01-14 修回日期:2014-03-31 出版日期:2015-05-28 发布日期:2015-06-26
  • 通讯作者: Faiyaz Shakeel

Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15 K to 333.15 K

Md Khalid Anwer1, Faiyaz Shakeel2,3   

  1. 1 Department of Pharmaceutics, College of Pharmacy, Salman Bin Abdulaziz University, Al-Kharj, Saudi Arabia;
    2 Center of Excellence in Biotechnology Research, King Saud University, Riyadh 11451, Saudi Arabia;
    3 Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
  • Received:2014-01-14 Revised:2014-03-31 Online:2015-05-28 Published:2015-06-26
  • Contact: Faiyaz Shakeel

摘要: The aimof present study was tomeasure and correlate the solubility of poorly water-soluble flavonoid diosmin in water, ethanol, isopropyl alcohol (IPA), polyethylene glycol-400 (PEG-400) and β-cyclodextrin (β-CD) aqueous solution (0.02 mol·L-1). The solubility of diosmin was measured using the shake flask method from (298.15 to 333.15) K at atmospheric pressure. The experimental solubilities of diosmin were regressed by the modified Apelblat model with a relative deviation in the range of 0.048% to 5.940%. The correlation coefficients were observed in the range of 0.9957 to 0.9995. The solubility of diosmin was found to be increased with temperature in all sample matrices investigated. The mole fraction solubility of diosmin was found to be higher in β-CD aqueous solution and PEG-400 as compared to water, ethanol and IPA. Based on solubility data of present study, diosmin was considered as practically insoluble in water, insoluble in ethanol & IPA and soluble in PEG-400 and β-CD aqueous solution.

关键词: Apelblat model, Cyclodextrin, Diosmin, Solubility, Thermodynamics

Abstract: The aimof present study was tomeasure and correlate the solubility of poorly water-soluble flavonoid diosmin in water, ethanol, isopropyl alcohol (IPA), polyethylene glycol-400 (PEG-400) and β-cyclodextrin (β-CD) aqueous solution (0.02 mol·L-1). The solubility of diosmin was measured using the shake flask method from (298.15 to 333.15) K at atmospheric pressure. The experimental solubilities of diosmin were regressed by the modified Apelblat model with a relative deviation in the range of 0.048% to 5.940%. The correlation coefficients were observed in the range of 0.9957 to 0.9995. The solubility of diosmin was found to be increased with temperature in all sample matrices investigated. The mole fraction solubility of diosmin was found to be higher in β-CD aqueous solution and PEG-400 as compared to water, ethanol and IPA. Based on solubility data of present study, diosmin was considered as practically insoluble in water, insoluble in ethanol & IPA and soluble in PEG-400 and β-CD aqueous solution.

Key words: Apelblat model, Cyclodextrin, Diosmin, Solubility, Thermodynamics