Chinese Journal of Chemical Engineering ›› 2015, Vol. 23 ›› Issue (4): 744-754.DOI: 10.1016/j.cjche.2014.05.020
• 综述 • 上一篇
Tao Wang1,2, Yafei Liang1,3, Mianbin Wu1,2,4, Zhengjie Chen4, Jianping Lin1,2, Lirong Yang1,2
收稿日期:2013-10-10
修回日期:2014-05-15
出版日期:2015-04-28
发布日期:2015-05-13
通讯作者:
Mianbin Wu
基金资助:Supported by theNationalNatural Science Foundation of China (21376215),the National Science and Technology Major Project of New Drug,China (2012ZX09103101-075),the Innovative Research Platform co-constructed by Zhejiang University and Taizhou City,and the Science and Technology Project of Zhejiang Province (2014C33174),the Major State Basic Research Development Program of China (2011CB710803),and the National High-Tech Research and Development Program of China (2012AA022302).
Tao Wang1,2, Yafei Liang1,3, Mianbin Wu1,2,4, Zhengjie Chen4, Jianping Lin1,2, Lirong Yang1,2
Received:2013-10-10
Revised:2014-05-15
Online:2015-04-28
Published:2015-05-13
Contact:
Mianbin Wu
Supported by:Supported by theNationalNatural Science Foundation of China (21376215),the National Science and Technology Major Project of New Drug,China (2012ZX09103101-075),the Innovative Research Platform co-constructed by Zhejiang University and Taizhou City,and the Science and Technology Project of Zhejiang Province (2014C33174),the Major State Basic Research Development Program of China (2011CB710803),and the National High-Tech Research and Development Program of China (2012AA022302).
摘要： Bacillus subtilis produces many chemically-diverse secondary metabolites of interest to chemists and biologists. Based on this, this review gives a detailed overview of the natural components produced by B. subtilis including cyclic lipopeptides, polypeptides, proteins (enzymes), and non-peptide products. Their structures, bioactive activities and the relevant variants as novel lead structures for drug discovery are also described. The challenging effects of fermentation metabolites, isolation and purification, as well as the overproduction of bioactive compounds from B. subtilis by metabolic engineering, were also highlighted. Systematically exploring biosynthetic routes and the functions of secondary metabolites from B. subtilis may not only be beneficial in improving yields of the products, but also in helping themto be used in food industry and publicmedical service on a large-scale.
Tao Wang, Yafei Liang, Mianbin Wu, Zhengjie Chen, Jianping Lin, Lirong Yang. Natural products from Bacillus subtilis with antimicrobial properties[J]. Chinese Journal of Chemical Engineering, 2015, 23(4): 744-754.
Tao Wang, Yafei Liang, Mianbin Wu, Zhengjie Chen, Jianping Lin, Lirong Yang. Natural products from Bacillus subtilis with antimicrobial properties[J]. Chin.J.Chem.Eng., 2015, 23(4): 744-754.
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