SCI和EI收录∣中国化工学会会刊

Chinese Journal of Chemical Engineering ›› 2015, Vol. 23 ›› Issue (4): 744-754.DOI: 10.1016/j.cjche.2014.05.020

• 综述 • 上一篇    

Natural products from Bacillus subtilis with antimicrobial properties

Tao Wang1,2, Yafei Liang1,3, Mianbin Wu1,2,4, Zhengjie Chen4, Jianping Lin1,2, Lirong Yang1,2   

  1. 1 Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Hangzhou 310027, China;
    2 Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China;
    3 JinhuaPeople's Hospital, Jinhua 321000, China;
    4 Zhejiang Key Laboratory of Antifungal Drugs, Taizhou 318000, China
  • 收稿日期:2013-10-10 修回日期:2014-05-15 出版日期:2015-04-28 发布日期:2015-05-13
  • 通讯作者: Mianbin Wu
  • 基金资助:

    Supported by theNationalNatural Science Foundation of China (21376215),the National Science and Technology Major Project of New Drug,China (2012ZX09103101-075),the Innovative Research Platform co-constructed by Zhejiang University and Taizhou City,and the Science and Technology Project of Zhejiang Province (2014C33174),the Major State Basic Research Development Program of China (2011CB710803),and the National High-Tech Research and Development Program of China (2012AA022302).

Natural products from Bacillus subtilis with antimicrobial properties

Tao Wang1,2, Yafei Liang1,3, Mianbin Wu1,2,4, Zhengjie Chen4, Jianping Lin1,2, Lirong Yang1,2   

  1. 1 Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Hangzhou 310027, China;
    2 Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China;
    3 JinhuaPeople's Hospital, Jinhua 321000, China;
    4 Zhejiang Key Laboratory of Antifungal Drugs, Taizhou 318000, China
  • Received:2013-10-10 Revised:2014-05-15 Online:2015-04-28 Published:2015-05-13
  • Contact: Mianbin Wu
  • Supported by:

    Supported by theNationalNatural Science Foundation of China (21376215),the National Science and Technology Major Project of New Drug,China (2012ZX09103101-075),the Innovative Research Platform co-constructed by Zhejiang University and Taizhou City,and the Science and Technology Project of Zhejiang Province (2014C33174),the Major State Basic Research Development Program of China (2011CB710803),and the National High-Tech Research and Development Program of China (2012AA022302).

摘要: Bacillus subtilis produces many chemically-diverse secondary metabolites of interest to chemists and biologists. Based on this, this review gives a detailed overview of the natural components produced by B. subtilis including cyclic lipopeptides, polypeptides, proteins (enzymes), and non-peptide products. Their structures, bioactive activities and the relevant variants as novel lead structures for drug discovery are also described. The challenging effects of fermentation metabolites, isolation and purification, as well as the overproduction of bioactive compounds from B. subtilis by metabolic engineering, were also highlighted. Systematically exploring biosynthetic routes and the functions of secondary metabolites from B. subtilis may not only be beneficial in improving yields of the products, but also in helping themto be used in food industry and publicmedical service on a large-scale.

关键词: Bacillus subtilis, Antimicrobial, Bioseparation, Drug design

Abstract: Bacillus subtilis produces many chemically-diverse secondary metabolites of interest to chemists and biologists. Based on this, this review gives a detailed overview of the natural components produced by B. subtilis including cyclic lipopeptides, polypeptides, proteins (enzymes), and non-peptide products. Their structures, bioactive activities and the relevant variants as novel lead structures for drug discovery are also described. The challenging effects of fermentation metabolites, isolation and purification, as well as the overproduction of bioactive compounds from B. subtilis by metabolic engineering, were also highlighted. Systematically exploring biosynthetic routes and the functions of secondary metabolites from B. subtilis may not only be beneficial in improving yields of the products, but also in helping themto be used in food industry and publicmedical service on a large-scale.

Key words: Bacillus subtilis, Antimicrobial, Bioseparation, Drug design