SCI和EI收录∣中国化工学会会刊

›› 2017, Vol. 25 ›› Issue (10): 1461-1466.DOI: 10.1016/j.cjche.2017.05.002

• Chemical Engineering Thermodynamics • 上一篇    下一篇

Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures

Lina Zhou1,2, Shichao Du1,2, Ting Wang1,2, Songgu Wu1,2, Zhiqiang Guo3, Zhao Wang1,2, Ling Zhou1,2   

  1. 1 School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China;
    2 The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Tianjin 300072, China;
    3 Tianjin Pharmaceuticals Research Institute Co. Ltd, Tianjin 300000, China
  • 收稿日期:2016-08-30 修回日期:2017-05-16 出版日期:2017-10-28 发布日期:2017-06-29
  • 通讯作者: Ling Zhou,E-mail address:zhouling@tju.edu.cn
  • 基金资助:
    Supported by Tianjin Municipal Natural Science Foundation (16JCYBJC19500) and China Ministry of Science and Major National Scientific Instrument Development Project (2016YFF0102503).

Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures

Lina Zhou1,2, Shichao Du1,2, Ting Wang1,2, Songgu Wu1,2, Zhiqiang Guo3, Zhao Wang1,2, Ling Zhou1,2   

  1. 1 School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China;
    2 The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Tianjin 300072, China;
    3 Tianjin Pharmaceuticals Research Institute Co. Ltd, Tianjin 300000, China
  • Received:2016-08-30 Revised:2017-05-16 Online:2017-10-28 Published:2017-06-29
  • Supported by:
    Supported by Tianjin Municipal Natural Science Foundation (16JCYBJC19500) and China Ministry of Science and Major National Scientific Instrument Development Project (2016YFF0102503).

摘要: The solubility of meropenem trihydrate in water + acetone mixtures and water + tetrahydrofuran mixtures were determined from T=(278.15 to 303.15) K by static method under atmospheric pressure. Effects of solvent composition and temperature on solubility of meropenem trihydrate were discussed. To extend the applicability of the solubility data, experimental solubility data in two kinds of binary solvent mixtures were correlated by the Apelblat equation and NIBS/Redlich-Kister model. It was found that the two models could satisfactorily correlate the experimental data and the Apelblat equation could give better correlation results.

关键词: Solubility, Meropenem trihydrate, Thermodynamics

Abstract: The solubility of meropenem trihydrate in water + acetone mixtures and water + tetrahydrofuran mixtures were determined from T=(278.15 to 303.15) K by static method under atmospheric pressure. Effects of solvent composition and temperature on solubility of meropenem trihydrate were discussed. To extend the applicability of the solubility data, experimental solubility data in two kinds of binary solvent mixtures were correlated by the Apelblat equation and NIBS/Redlich-Kister model. It was found that the two models could satisfactorily correlate the experimental data and the Apelblat equation could give better correlation results.

Key words: Solubility, Meropenem trihydrate, Thermodynamics