SCI和EI收录∣中国化工学会会刊

Chinese Journal of Chemical Engineering ›› 2018, Vol. 26 ›› Issue (3): 566-573.DOI: 10.1016/j.cjche.2017.09.009

• Chemical Engineering Thermodynamics • 上一篇    下一篇

Interaction of antipsychotic drug with novel surfactants: Micellization and binding studies

Naved Azum, Malik Abdul Rub, Abdullah M. Asiri   

  1. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia;Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
  • 收稿日期:2017-05-03 修回日期:2017-09-14 出版日期:2018-03-28 发布日期:2018-04-18
  • 通讯作者: Naved Azum

Interaction of antipsychotic drug with novel surfactants: Micellization and binding studies

Naved Azum, Malik Abdul Rub, Abdullah M. Asiri   

  1. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia;Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
  • Received:2017-05-03 Revised:2017-09-14 Online:2018-03-28 Published:2018-04-18
  • Contact: Naved Azum

摘要: The interaction of cationic gemini surfactants (alkanediyl-α,ω-bis(alkyl dimethylammonium bromide)) with an antipsychotic drug (chlorpromazine hydrochloride (CPZ)) has been investigated. Various micellar and interfacial parameters have been deliberated by surface tension measurement to report the nature of interactions between drug and novel surfactant mixtures. The behavior of mixed systems, their compositions and activities of components have been analyzed in the light of Rubingh's theory. The results indicate synergism in the binary mixtures. The binding study between CPZ and surfactants has been done by spectroscopic techniques such as UV-visible and fluorescence. The results are discussed in the light of the use of gemini surfactants as promising drug delivery agents for phenothiazine drugs, and hence, improve their bioavailability.

关键词: Gemini surfactants, Antipsychotic drug, Chlorpromazine hydrochloride, Mixed micellization

Abstract: The interaction of cationic gemini surfactants (alkanediyl-α,ω-bis(alkyl dimethylammonium bromide)) with an antipsychotic drug (chlorpromazine hydrochloride (CPZ)) has been investigated. Various micellar and interfacial parameters have been deliberated by surface tension measurement to report the nature of interactions between drug and novel surfactant mixtures. The behavior of mixed systems, their compositions and activities of components have been analyzed in the light of Rubingh's theory. The results indicate synergism in the binary mixtures. The binding study between CPZ and surfactants has been done by spectroscopic techniques such as UV-visible and fluorescence. The results are discussed in the light of the use of gemini surfactants as promising drug delivery agents for phenothiazine drugs, and hence, improve their bioavailability.

Key words: Gemini surfactants, Antipsychotic drug, Chlorpromazine hydrochloride, Mixed micellization