Advancement in separation materials for blood purification therapy

doi:10.1016/j.cjche.2019.01.022

中国化学工程学报 ›› 2019, Vol. 27 ›› Issue (6): 1383-1390.DOI: 10.1016/j.cjche.2019.01.022

• Special Issue: Separation Process Intensification of Chemical Engineering • 上一篇下一篇

Advancement in separation materials for blood purification therapy

Jia Ju¹, Feixue Liang¹, Xiaoxin Zhang¹, Ran Sun¹, Xiaoguang Pan², Xiaoyun Guan¹, Guanning Cui¹, Xuan He¹, Mengyan Li¹

1 College of Chemistry, Chemical Engineering and Environmental Engineering, Liaoning Shihua University, Fushun 113001, China;
2 School of Computer and Communication Engineering, Liaoning Shihua University, Fushun 113001, China

收稿日期:2018-10-09 修回日期:2019-01-14 出版日期:2019-06-28 发布日期:2019-08-19
通讯作者: Jia Ju
基金资助:
Supported by the National Natural Science Foundation of China (No. 21606120) and National Undergraducate Training Program for Innovation and Entrepreneurship (Nos. 201710148000016 and 201810148080).

Advancement in separation materials for blood purification therapy

Jia Ju¹, Feixue Liang¹, Xiaoxin Zhang¹, Ran Sun¹, Xiaoguang Pan², Xiaoyun Guan¹, Guanning Cui¹, Xuan He¹, Mengyan Li¹

1 College of Chemistry, Chemical Engineering and Environmental Engineering, Liaoning Shihua University, Fushun 113001, China;
2 School of Computer and Communication Engineering, Liaoning Shihua University, Fushun 113001, China

Received:2018-10-09 Revised:2019-01-14 Online:2019-06-28 Published:2019-08-19
Contact: Jia Ju
Supported by:
Supported by the National Natural Science Foundation of China (No. 21606120) and National Undergraducate Training Program for Innovation and Entrepreneurship (Nos. 201710148000016 and 201810148080).

摘要/Abstract

摘要： Blood purification refers to the extra corporeal therapies of removing potentially toxic substances, in which blood is circulated through an adsorption system loading separation materials. High-efficient inexpensive separation materials are critical to success. In this review, separation materials such as polymers and nanomaterials are summarized and compared. Combining the advantages of the adsorptive membranes and nanomaterials, organic-inorganic hybrid/blend membranes have been developed explosively. These hybrid/blend membranes have both the characteristics of high permeability, easy fabrication, good biocompatibility of adsorptive membranes, and characteristics of fast adsorption rate and high adsorption capacity of nanomaterials. The preparation and modification methodology of the separation materials is reviewed. For affinity separation materials, the relationship of ligand chemistry, ligand density and pores of the matrix is discussed. This paper also summarizes some interesting applications in separation materials for removal of bilirubin, endotoxin, toxic metal ions, cytokine, etc.

关键词: Blood purification, Organic inorganic hybrid/blend membrane, Albumin-bound toxins, Preparation and modification, Ligand density

Abstract: Blood purification refers to the extra corporeal therapies of removing potentially toxic substances, in which blood is circulated through an adsorption system loading separation materials. High-efficient inexpensive separation materials are critical to success. In this review, separation materials such as polymers and nanomaterials are summarized and compared. Combining the advantages of the adsorptive membranes and nanomaterials, organic-inorganic hybrid/blend membranes have been developed explosively. These hybrid/blend membranes have both the characteristics of high permeability, easy fabrication, good biocompatibility of adsorptive membranes, and characteristics of fast adsorption rate and high adsorption capacity of nanomaterials. The preparation and modification methodology of the separation materials is reviewed. For affinity separation materials, the relationship of ligand chemistry, ligand density and pores of the matrix is discussed. This paper also summarizes some interesting applications in separation materials for removal of bilirubin, endotoxin, toxic metal ions, cytokine, etc.

Key words: Blood purification, Organic inorganic hybrid/blend membrane, Albumin-bound toxins, Preparation and modification, Ligand density

Jia Ju, Feixue Liang, Xiaoxin Zhang, Ran Sun, Xiaoguang Pan, Xiaoyun Guan, Guanning Cui, Xuan He, Mengyan Li. Advancement in separation materials for blood purification therapy[J]. 中国化学工程学报, 2019, 27(6): 1383-1390.

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Advancement in separation materials for blood purification therapy

Advancement in separation materials for blood purification therapy

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