SCI和EI收录∣中国化工学会会刊

中国化学工程学报 ›› 2020, Vol. 28 ›› Issue (1): 216-223.DOI: 10.1016/j.cjche.2019.03.019

• Chemical Engineering Thermodynamics • 上一篇    下一篇

Interaction of ciprofloxacin hydrochloride with sodium dodecyl sulfate in aqueous/electrolytes solution at different temperatures and compositions

Sk. Md. Ali Ahsan1, Md. Ruhul Amin1, Shamim Mahbub1, Mohammad Robel Molla1, Shahina Aktar1, Malik Abdul Rub2,3, Md. Anamul Hoque1, Muhammad Nadeem Arshad2,3, Mohammed Abdullah Khan1   

  1. 1 Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh;
    2 Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah-21589, Saudi Arabia;
    3 Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah-21589, Saudi Arabia
  • 收稿日期:2018-12-21 修回日期:2019-02-20 出版日期:2020-01-28 发布日期:2020-03-31
  • 通讯作者: Md. Anamul Hoque

Interaction of ciprofloxacin hydrochloride with sodium dodecyl sulfate in aqueous/electrolytes solution at different temperatures and compositions

Sk. Md. Ali Ahsan1, Md. Ruhul Amin1, Shamim Mahbub1, Mohammad Robel Molla1, Shahina Aktar1, Malik Abdul Rub2,3, Md. Anamul Hoque1, Muhammad Nadeem Arshad2,3, Mohammed Abdullah Khan1   

  1. 1 Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh;
    2 Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah-21589, Saudi Arabia;
    3 Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah-21589, Saudi Arabia
  • Received:2018-12-21 Revised:2019-02-20 Online:2020-01-28 Published:2020-03-31
  • Contact: Md. Anamul Hoque

摘要: Interactions of ciprofloxacin hydrochloride (CPFH) with sodium dodecyl sulfate (SDS) were investigated by conductivity measurement in H2O/electrolyte solutions (NaCl, Na2SO4 & Na3PO4) over 298.15-318.15 K temperature range (with 5 K interval) considering the human body temperature. In all cases, two critical micelle concentrations (c*) were observed which are increased in the presence of drug and decreased in the presence of salts enunciating the presence of interaction amongst the studied components. For (CPFH+SDS) system in the presence of salt, the c* values at 303.15 K and I=0.50 mmol·kg-1 followed the order:CNaCl > CNa2SO4 > CNa3PO4. The G1,m0 and ΔG2,m0 values are found to be negative for all systems that show that the micellization process is thermodynamically spontaneous. For (CPFH+SDS) system in water, the ΔHm0 & ΔSm0values reveal that the micellization processes is both entropy dominated in almost all cases. In the occurrence of electrolytes, ΔHm0 and ΔSm0 values indicate that micellization processes are both entropy & enthalpy restricted at upper temperature but it becomes totally entropy dependent at higher temperature. The higher positive ΔSm0 values indicate the enhanced hydrophobic interaction in presence of salts. The enthalpy-entropy compensation was determined from the linear relationship between ΔHm0 and ΔSm0 values in every state. Different transfer energies as well as compensation temperature and intrinsic enthalpy were also evaluated and the behaviors were comparable to other biological system.

关键词: Ciprofloxacin hydrochloride, Sodium dodecyl sulfate, Critical micelle concentration, Thermodynamic indices, Hydrophobic effect

Abstract: Interactions of ciprofloxacin hydrochloride (CPFH) with sodium dodecyl sulfate (SDS) were investigated by conductivity measurement in H2O/electrolyte solutions (NaCl, Na2SO4 & Na3PO4) over 298.15-318.15 K temperature range (with 5 K interval) considering the human body temperature. In all cases, two critical micelle concentrations (c*) were observed which are increased in the presence of drug and decreased in the presence of salts enunciating the presence of interaction amongst the studied components. For (CPFH+SDS) system in the presence of salt, the c* values at 303.15 K and I=0.50 mmol·kg-1 followed the order:CNaCl > CNa2SO4 > CNa3PO4. The G1,m0 and ΔG2,m0 values are found to be negative for all systems that show that the micellization process is thermodynamically spontaneous. For (CPFH+SDS) system in water, the ΔHm0 & ΔSm0values reveal that the micellization processes is both entropy dominated in almost all cases. In the occurrence of electrolytes, ΔHm0 and ΔSm0 values indicate that micellization processes are both entropy & enthalpy restricted at upper temperature but it becomes totally entropy dependent at higher temperature. The higher positive ΔSm0 values indicate the enhanced hydrophobic interaction in presence of salts. The enthalpy-entropy compensation was determined from the linear relationship between ΔHm0 and ΔSm0 values in every state. Different transfer energies as well as compensation temperature and intrinsic enthalpy were also evaluated and the behaviors were comparable to other biological system.

Key words: Ciprofloxacin hydrochloride, Sodium dodecyl sulfate, Critical micelle concentration, Thermodynamic indices, Hydrophobic effect