SCI和EI收录∣中国化工学会会刊

中国化学工程学报 ›› 2020, Vol. 28 ›› Issue (5): 1405-1414.DOI: 10.1016/j.cjche.2019.12.013

• Materials and Product Engineering • 上一篇    下一篇

Hollow MnO2/GNPs serving as a multiresponsive nanocarrier for controlled drug release

Zheng Zhang1, Yuanhui Ji1, Wei Chen2   

  1. 1 Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China;
    2 Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China
  • 收稿日期:2019-07-03 修回日期:2019-11-21 出版日期:2020-05-28 发布日期:2020-07-29
  • 通讯作者: Yuanhui Ji
  • 基金资助:
    The study was supported by the National Natural Science Foundation of China (Grant Nos.:21776046, 21606043), the Six Talent Peaks Project in Jiangsu Province (Grant No.:XCL-079), the Fundamental Research Funds for the Central Universities (Grant No.:2242019K40145), the Cooperative Research Project between Southeast University and China Pharmaceutical University, and the Recruitment Program for Young Professionals (the Thousand Youth Talents Plan).

Hollow MnO2/GNPs serving as a multiresponsive nanocarrier for controlled drug release

Zheng Zhang1, Yuanhui Ji1, Wei Chen2   

  1. 1 Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China;
    2 Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China
  • Received:2019-07-03 Revised:2019-11-21 Online:2020-05-28 Published:2020-07-29
  • Contact: Yuanhui Ji
  • Supported by:
    The study was supported by the National Natural Science Foundation of China (Grant Nos.:21776046, 21606043), the Six Talent Peaks Project in Jiangsu Province (Grant No.:XCL-079), the Fundamental Research Funds for the Central Universities (Grant No.:2242019K40145), the Cooperative Research Project between Southeast University and China Pharmaceutical University, and the Recruitment Program for Young Professionals (the Thousand Youth Talents Plan).

摘要: In this work, hollow manganese dioxide/gold nanoparticle (MnO2/GNPs) hybrid drug nanocarriers were prepared by coupling the gold nanoparticles (GNPs) with hollow structure manganese dioxide (MnO2). Among them, GNPs have been used as near-infrared (NIR)-responsive element for photothermal effect under NIR laser irradiation. The glutathione (GSH)-responsive and pH-responsive performances of drug release were derived from hollow MnO2. Particularly, Doxorubicin hydrochloride (DOX) can be loaded into hollow MnO2/GNPs with the drug loading efficiency up to 82.0%. Moreover, the photothermal effect and GSH-/pH-responsive properties of hollow MnO2/GNPs were investigated. The hollow MnO2/GNPs possessed satisfactory drug release efficiency (ca. 87.4% of loaded drug released in 12 h) and have high photothermal conversion efficiency, multiresponsive properties, and degradability. Finally, the kinetics of drug release was discussed in detail. Thus, our finding highlights that the multiresponsive nanocarriers are of great potential in the field of drug controlled release.

关键词: Hollow manganese dioxide, Gold nanoparticles, Photothermal effect, GSH-/pH-responsive properties, Drug release

Abstract: In this work, hollow manganese dioxide/gold nanoparticle (MnO2/GNPs) hybrid drug nanocarriers were prepared by coupling the gold nanoparticles (GNPs) with hollow structure manganese dioxide (MnO2). Among them, GNPs have been used as near-infrared (NIR)-responsive element for photothermal effect under NIR laser irradiation. The glutathione (GSH)-responsive and pH-responsive performances of drug release were derived from hollow MnO2. Particularly, Doxorubicin hydrochloride (DOX) can be loaded into hollow MnO2/GNPs with the drug loading efficiency up to 82.0%. Moreover, the photothermal effect and GSH-/pH-responsive properties of hollow MnO2/GNPs were investigated. The hollow MnO2/GNPs possessed satisfactory drug release efficiency (ca. 87.4% of loaded drug released in 12 h) and have high photothermal conversion efficiency, multiresponsive properties, and degradability. Finally, the kinetics of drug release was discussed in detail. Thus, our finding highlights that the multiresponsive nanocarriers are of great potential in the field of drug controlled release.

Key words: Hollow manganese dioxide, Gold nanoparticles, Photothermal effect, GSH-/pH-responsive properties, Drug release