Hollow MnO2/GNPs serving as a multiresponsive nanocarrier for controlled drug release

doi:10.1016/j.cjche.2019.12.013

中国化学工程学报 ›› 2020, Vol. 28 ›› Issue (5): 1405-1414.DOI: 10.1016/j.cjche.2019.12.013

• Materials and Product Engineering • 上一篇下一篇

Hollow MnO₂/GNPs serving as a multiresponsive nanocarrier for controlled drug release

Zheng Zhang¹, Yuanhui Ji¹, Wei Chen²

1 Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China;
2 Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China

收稿日期:2019-07-03 修回日期:2019-11-21 出版日期:2020-05-28 发布日期:2020-07-29
通讯作者: Yuanhui Ji
基金资助:
The study was supported by the National Natural Science Foundation of China (Grant Nos.:21776046, 21606043), the Six Talent Peaks Project in Jiangsu Province (Grant No.:XCL-079), the Fundamental Research Funds for the Central Universities (Grant No.:2242019K40145), the Cooperative Research Project between Southeast University and China Pharmaceutical University, and the Recruitment Program for Young Professionals (the Thousand Youth Talents Plan).

Hollow MnO₂/GNPs serving as a multiresponsive nanocarrier for controlled drug release

Zheng Zhang¹, Yuanhui Ji¹, Wei Chen²

1 Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China;
2 Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China

Received:2019-07-03 Revised:2019-11-21 Online:2020-05-28 Published:2020-07-29
Contact: Yuanhui Ji
Supported by:
The study was supported by the National Natural Science Foundation of China (Grant Nos.:21776046, 21606043), the Six Talent Peaks Project in Jiangsu Province (Grant No.:XCL-079), the Fundamental Research Funds for the Central Universities (Grant No.:2242019K40145), the Cooperative Research Project between Southeast University and China Pharmaceutical University, and the Recruitment Program for Young Professionals (the Thousand Youth Talents Plan).

摘要/Abstract

摘要： In this work, hollow manganese dioxide/gold nanoparticle (MnO₂/GNPs) hybrid drug nanocarriers were prepared by coupling the gold nanoparticles (GNPs) with hollow structure manganese dioxide (MnO₂). Among them, GNPs have been used as near-infrared (NIR)-responsive element for photothermal effect under NIR laser irradiation. The glutathione (GSH)-responsive and pH-responsive performances of drug release were derived from hollow MnO₂. Particularly, Doxorubicin hydrochloride (DOX) can be loaded into hollow MnO₂/GNPs with the drug loading efficiency up to 82.0%. Moreover, the photothermal effect and GSH-/pH-responsive properties of hollow MnO₂/GNPs were investigated. The hollow MnO₂/GNPs possessed satisfactory drug release efficiency (ca. 87.4% of loaded drug released in 12 h) and have high photothermal conversion efficiency, multiresponsive properties, and degradability. Finally, the kinetics of drug release was discussed in detail. Thus, our finding highlights that the multiresponsive nanocarriers are of great potential in the field of drug controlled release.

关键词: Hollow manganese dioxide, Gold nanoparticles, Photothermal effect, GSH-/pH-responsive properties, Drug release

Abstract: In this work, hollow manganese dioxide/gold nanoparticle (MnO₂/GNPs) hybrid drug nanocarriers were prepared by coupling the gold nanoparticles (GNPs) with hollow structure manganese dioxide (MnO₂). Among them, GNPs have been used as near-infrared (NIR)-responsive element for photothermal effect under NIR laser irradiation. The glutathione (GSH)-responsive and pH-responsive performances of drug release were derived from hollow MnO₂. Particularly, Doxorubicin hydrochloride (DOX) can be loaded into hollow MnO₂/GNPs with the drug loading efficiency up to 82.0%. Moreover, the photothermal effect and GSH-/pH-responsive properties of hollow MnO₂/GNPs were investigated. The hollow MnO₂/GNPs possessed satisfactory drug release efficiency (ca. 87.4% of loaded drug released in 12 h) and have high photothermal conversion efficiency, multiresponsive properties, and degradability. Finally, the kinetics of drug release was discussed in detail. Thus, our finding highlights that the multiresponsive nanocarriers are of great potential in the field of drug controlled release.

Key words: Hollow manganese dioxide, Gold nanoparticles, Photothermal effect, GSH-/pH-responsive properties, Drug release

Zheng Zhang, Yuanhui Ji, Wei Chen. Hollow MnO₂/GNPs serving as a multiresponsive nanocarrier for controlled drug release[J]. 中国化学工程学报, 2020, 28(5): 1405-1414.

Zheng Zhang, Yuanhui Ji, Wei Chen. Hollow MnO₂/GNPs serving as a multiresponsive nanocarrier for controlled drug release[J]. Chinese Journal of Chemical Engineering, 2020, 28(5): 1405-1414.

参考文献

[1] Q.Y. Tang, Z.J. Cheng, N. Yang, Q.Z. Li, P. Wang, D.P. Chen, W.J. Wang, X.J. Song, X.C. Dong, Hydrangea-structured tumor microenvironment responsive degradable nanoplatform for hypoxic tumor multimodal imaging and therapy, Biomaterials 205(2019) 1-10.
[2] X.J. Zhou, F. Chen, H.P. Lu, L.L. Kong, S.Y. Zhang, W. Zhang, J.J. Nie, B.Y. Du, X.P. Wang, Ionic microgel loaded with gold nanoparticles for the synergistic dual-drug delivery of doxorubicin and diclofenac sodium, Ind. Eng. Chem. Res. 58(25) (2019) 10922-10930.
[3] S.W. Niu, G.R. Williams, J.R. Wu, J.Z. Wu, X.J. Zhang, H. Zheng, S.D. Li, L.M. Zhu, A novel chitosan-based nanomedicine for multi-drug resistant breast cancer therapy, Chem. Eng. J. 369(2019) 134-149.
[4] L.Y. Shen, S. Pan, D.C. Niu, J.P. He, X.B. Jia, J.N. Hao, J.L. Gu, W.R. Zhao, P. Li, Y.S. Li, Facile synthesis of organosilica-capped mesoporous silica nanocarriers with selective redox-triggered drug release properties for safe tumor chemotherapy, Biomaterials science 7(5) (2019) 1825-1832.
[5] Q. Zeng, R.J. Zhang, T. Zhang, D. Xing, H₂O₂-responsive biodegradable nanomedicine for cancer-selective dual-modal imaging guided precise photodynamic therapy, Biomaterials 207(2019) 39-48.
[6] M. Chung, H. Liu, K. Lin, W.T. Chia, H. Sung, A pH responsive carrier system that generates NO bubbles to trigger drug release and reverse p-glycoprotein-mediated multidrug resistance, Angew. Chem. Int. Ed. 54(34) (2015) 9890-9893.
[7] M.A. Swartz, N. Iida, E.W. Roberts, S. Sangaletti, M.H. Wong, F.E. Yull, L.M. Coussens, Y.A. DeClerck, Tumor microenvironment complexity:Emerging roles in cancer therapy, Cancer Res. 72(2012) 2473-2480.
[8] R. Mortera, J. Vivero-Escoto II., E. Slowing, B. Garrone, V.S. Lin Onida, Cell-induced intracellular controlled release of membrane impermeable cysteine from a mesoporous silica nanoparticle-based drug delivery system, Chem. Commun. 22(2009) 3219-3221.
[9] R. Hong, G. Han, J.M. Fernández, B.J. Kim, N.S. Forbes, V.M. Rotello, Glutathionemediated delivery and release using monolayer protected nanoparticle carriers, J. Am. Chem. Soc. 128(4) (2006) 1078-1079.
[10] J. Wang, X. Sun, W. Mao, W. Sun, J. Tang, M. Sui, Y. Shen, Z. Gu, Tumor redox heterogeneity-responsive prodrug nanocapsules for cancer chemotherapy, Adv. Mater. 25(27) (2013) 3670-3676.
[11] T.B. Ren, W.J. Xia, H.Q. Dong, Y.Y. Li, Sheddable micelles based on disulfide-linked hybrid PEG-polypeptide copolymer for intracellular drug delivery, Polymer 52(16) (2011) 3580-3586.
[12] S. Takae, K. Miyata, M. Oba, T. Ishii, N. Nishiyama, K. Itaka, Y. Yamasaki, H. Koyama, K. Kataoka, PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors, J. Am. Chem. Soc. 130(18) (2008) 6001-6009.
[13] R. Cheng, F. Feng, F. Meng, C. Deng, J. Feijen, Z. Zhong, Glutathione-responsive nanovehicles as a promising platform for targeted intracellular drug and gene delivery, J. Control. Release 152(1) (2011) 2-12.
[14] M. Song, T. Liu, C. Shi, X. Zhang, X. Chen, Bioconjugated manganese dioxide nanoparticles enhance chemotherapy response by priming tumor-associated macrophages toward M1-like phenotype and attenuating tumor hypoxia, ACS Nano 10(1) (2015) 633-647.
[15] Y. Li, J. Jin, D. Wang, J. Lv, K. Hou, Y. Liu, C. Chen, Z. Tang, Coordination-responsive drug release inside gold nanorod@metal-organic framework core-shell nanostructures for near-infrared-induced synergistic chemo-photothermal therapy, Nano Res. 11(6) (2017) 3294-3305.
[16] L.T. Meng, Y.L. Cheng, X.N. Tong, S.J. Gan, Y.W. Ding, Y. Zhang, C. Wang, L. Xu, Y.S. Zhu, J.H. Wu, Y.Q. Hu, A. Yuan, Tumor oxygenation and hypoxia inducible factor-1 functional inhibition via a reactive oxygen species responsive nanoplatform for enhancing radiation therapy and abscopal effects, ACS Nano 12(8) (2018) 8308-8322.
[17] W. Zhu, Z. Dong, T. Fu, J. Liu, Q. Chen, Y. Li, R. Zhu, L. Xu, Z. Liu, Modulation of hypoxia in solid tumor microenvironment with MnO₂ nanoparticles to enhance photodynamic therapy, Adv. Funct. Mater. 26(30) (2016) 5490-5498.
[18] P. Prasad, C.R. Gordijo, A.Z. Abbasi, A. Maeda, A. Ip, A.M. Rauth, R.S. DaCosta, X.Y. Wu, Multifunctional albumin-MnO₂ nanoparticles modulate solid tumor microenvironment by attenuating hypoxia, acidosis, vascular endothelial growth factor and enhance radiation response, ACS Nano 8(4) (2014) 3202-3212.
[19] Q. Chen, L.Z. Feng, J.J. Liu, W.W. Zhu, Z.L. Dong, Y.F. Wu, Z. Liu, Intelligent albuminMnO₂ nanoparticles as pH-/H₂O₂-responsive dissociable nanocarriers to modulate tumor hypoxia for effective combination therapy, Adv. Mater. 28(33) (2016) 7129-7136.
[20] J. Chen, H.M. Meng, Y. Tian, R. Yang, D. Du, Z.H. Li, L.B. Qu, Y.H. Lin, Recent advances in functionalized MnO₂ nanosheets for biosensing and biomedicine applications, Nanoscale Horiz. 4(2) (2019) 321-338.
[21] L.S. Lin, J.B. Song, L. Song, K.M. Ke, Y.J. Liu, Z.J. Zhou, Z.Y. Shen, J. Li, Z. Yang, W. Tang, G. Niu, H.H. Yang, X.Y. Chen, Simultaneous Fenton-like ion delivery and glutathione depletion by MnO₂-based nanoagent to enhance chemodynamic therapy, Angew. Chem. Int. Ed. 57(18) (2018) 4902-4906.
[22] Z.Liu,S.J.Zhang,H.Lin,M.L.Zhao,H.L.Yao,L.L.Zhang,W.J.Peng,Y.Chen,Theranostic 2D ultrathin MnO₂ nanosheets with fast responsibility to endogenous tumor microenvironment and exogenous NIR irradiation, Biomaterials 155(2018) 54-63.
[23] D.G. He, L. Hai, X. He, X. Yang, H.W. Li, Glutathione-activatable and O₂/Mn²⁺-evolving nanocomposite for highly efficient and selective photodynamic and gene-silencing dual therapy, Adv. Funct. Mater. 27(46) (2017) 1704089.
[24] M.L. Song, T. Liu, C.R. Shi, X.Z. Zhang, X.Y. Chen, Bioconjugated manganese dioxide nanoparticles enhance chemotherapy response by priming tumor-associated macrophages toward M1-like phenotype and attenuating tumor hypoxia, ACS Nano 10(1) (2016) 633-647.
[25] C.C. Chu, H.R. Lin, H. Liu, X.Y. Wang, J.Q. Wang, P.F. Zhang, H.Y. Gao, C. Huang, Y. Zeng, Y.Z. Tan, G. Liu, X.Y. Chen, Tumor microenvironment-triggered supramolecular system as an in situ nanotheranostic generator for cancer phototherapy, Adv. Mater. 29(23) (2017) 1605928.
[26] R.G. Wang, M.Y. Zhao, D. Deng, X. Ye, F. Zhang, H. Chen, J.L. Kong, An intelligent and biocompatible photosensitizer conjugated silicon quantum dots-MnO₂ nanosystem for fluorescence imaging-guided efficient photodynamic therapy, J. Mater. Chem. B 6(28) (2018) 4592-4601.
[27] L.H. Jin, J.H. Liu, Y. Tang, L.Q. Cao, T.Q. Zhang, Q.H. Yuan, Y.H. Wang, H.J. Zhang, MnO₂-functionalized Co-P nanocomposite:A new theranostic agent for pHtriggered T1/T2 dual-modality magnetic resonance imaging-guided chemophotothermal synergistic therapy, ACS Appl. Mater. Interfaces 9(48) (2017) 41648-41658.
[28] W.P. Fan, W.B. Bu, B. Shen, Q.J. He, Z.W. Cui, Y.Y. Liu, X.P. Zheng, K.L. Zhao, J.L. Shi, Intelligent MnO₂ nanosheets anchored with upconversion nanoprobes for concurrent pH-/H₂O₂-responsive UCL imaging and oxygen-elevated synergetic therapy, Adv. Mater. 27(28) (2015) 4155-4161.
[29] R.H. Yang, M.M. Hou, Y. Gao, L. Zhang, Z.G. Xu, Y.J. Kang, P. Xue, Indocyanine greenmodified hollow mesoporous prussian blue nanoparticles loading doxorubicin for fluorescence-guided tri-modal combination therapy of cancer, Nanoscale 11(12) (2019) 5717-5731.
[30] Q. Li, L.H. Sun, M.M. Hou, Q.B. Chen, R.H. Yang, L. Zhang, Z.G. Xu, Y.J. Kang, P. Xue, Phase-change material packaged within hollow copper sulfide nanoparticles carrying doxorubicin and chlorin e6 for fluorescence-guided trimodal therapy of cancer, ACS Appl. Mater. Interfaces 11(1) (2019) 417-429.
[31] Y.T. Li, J. Jin, D.W. Wang, J.W. Lv, K. Hou, Y.L. Liu, C.Y. Chen, Z.Y. Tang, Coordinationresponsive drug release inside gold nanorod@metal-organic framework core-shell nanostructures for near-infrared-induced synergistic chemo-photothermal therapy, Nano Res. 11(6) (2018) 3294-3305.
[32] X.Y. Chen, Q. Zhang, J.L. Li, M. Yang, N.N. Zhao, F.J. Xu, Rattle-structured rough nanocapsules with in-situ-formed reil gold nanorod cores for complementary gene/chemo/photothermal therapy, ACS Nano 12(6) (2018) 5646-5656.
[33] C. Xu, F. Chen, H.F. Valdovinos, D.W. Jiang, S. Goel, B. Yu, H.Y. Sun, T.E. Barnhart, J.J. Moon, W.B. Cai, Bacteria-like mesoporous silica-coated gold nanorods for positron emission tomography and photoacoustic imaging-guided chemo-photothermal combined therapy, Biomaterials 165(2018) 56-65.
[34] W. Li, H.B. Zhang, X.M. Guo, Z.H. Wang, F.F. Kong, L.H. Luo, Q.P. Li, C.Q. Zhu, J. Yang, Y. Lou, Y.Z. Du, J. You, Gold nanospheres-stabilized indocyanine green as a synchronous photodynamic-photothermal therapy platform that inhibits tumor growth and metastasis, ACS Appl. Mater. Interfaces 9(4) (2017) 3354-3367.
[35] X.R. Deng, Y.Y. Chen, Z.Y. Cheng, K.R. Deng, P.A. Ma, Z.Y. Hou, B. Liu, S.S. Huang, D.Y. Jin, J. Lin, Rational design of a comprehensive cancer therapy platform using temperature-sensitive polymer grafted hollow gold nanospheres:simultaneous chemo/photothermal/photodynamic therapy triggered by a 650 nm laser with enhanced anti-tumor efficacy, Nanoscale 8(12) (2016) 6837-6850.
[36] J. You, G.D. Zhang, C. Li, Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release, ACS Nano 4(2) (2010) 1033-1041.
[37] N.X. Zhao, J. You, Z.H. Zeng, C. Li, Y.L. Zu, An ultra pH-sensitive and aptamerequipped nanoscale drug-delivery system for selective killing of tumor cells, Small 9(20) (2013) 3477-3484.
[38] W. Li, X.M. Guo, F.F. Kong, H.B. Zhang, L.H. Luo, Q.P. Li, C.Q. Zhu, J. Yang, Y.Z. Du, J. You, Overcoming photodynamic resistance and tumor targeting dual-therapy mediated by indocyanine green conjugated gold nanospheres, J. Control. Release 258(2017) 171-181.
[39] P.Y. Zhang, J.Q. Wang, H.Y. Huang, B.L. Yu, K.Q. Qiu, J.J. Huang, S.T. Wang, L. Jiang, G. Gasser, L.N. Ji, H. Chao, Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes:A way towards cancer therapy? Biomaterials 63(2015) 102-114.
[40] R. Guo, R.T. Li, X.L. Li, L.Y. Zhang, X.Q. Jiang, B.R. Liu, Dual-functional alginic acid hybrid nanospheres for cell imaging and drug delivery, Small 5(6) (2009) 709-7171.
[41] H. Deng, F. Dai, G. Ma, X. Zhang, Theranostic gold nanomicelles made from biocompatible comb-like polymers for thermochemotherapy and multifunctional imaging with rapid clearance, Adv. Mater. 27(24) (2015) 3645-3653.
[42] R. Guo, R.T. Li, X.L. Li, L.Y. Zhang, X.Q. Jiang, B.R. Liu, Dual-functional alginic acid hybrid nanospheres for cell imaging and drug delivery, Small 5(6) (2009) 709-717.
[43] Z.M. Wang, L.N. Chen, Z.Y. Chu, C.S. Huang, Y.K. Huang, N.Q. Jia, Gemcitabine-loaded gold nanospheres mediated by albumin for enhanced anti-tumor activity combining with CT imaging, Mater. Sci. Eng. C. 89(2018) 106-118.
[44] Q.J. Li, M. Chen, D.Y. Chen, L.M. Wu, One-pot synthesis of diphenylalanine-based hybrid nanospheres for controllable pH-and GSH-responsive delivery of drugs, Chem. Mater. 28(18) (2016) 6584-6590.
[45] X. Huang, X. Teng, D. Chen, F. Tang, J. He, The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function, Biomaterials 31(3) (2010) 438-448.
[46] H. Wang, R. Zhao, Y. Li, H. Liu, F. Li, Y. Zhao, G. Nie, Aspect ratios of gold nanoshell capsules mediated melanoma ablation by synergistic photothermal therapy and chemotherapy, Nanomedicine 12(2) (2016) 439-448.
[47] R. Zhao, X. Han, Y. Li, H. Wang, T. Ji, Y. Zhao, G. Nie, Photothermal effect enhanced cascade-targeting strategy for improved pancreatic cancer therapy by gold nanoshell@mesoporous silica nanorod, ACS Nano 11(8) (2017) 1418-1423.
[48] J. Wei, J. Shi, Q. Wu, L. Yang, S.K. Cao, Hollow hydroxyapatite/polyelectrolyte hybrid microparticles with controllable size, wall thickness and drug delivery properties, J. Mater. Chem. B 3(41) (2015) 8162-8169.
[49] Z. Zhang, Y.H. Ji, Mesoporous manganese dioxide coated gold nanorods as a multiresponsive nanoplatform for drug delivery, Ind. Eng. Chem. Res. 58(8) (2019) 2991-2999.
[50] S.A. Alzahrani, S.A. Al-Thabaiti, W.S. Al-Arjan, M.A. Malik, Z. Khan, Preparation of ultra long α-MnO₂ and Ag@MnO₂ nanoparticles by seedless approach and their photocatalytic performance, J. Mol. Struct. 1137(5) (2017) 495-505.
[51] W. Zhang, F. Wang, Y. Wang, J. Wang, Y. Yu, S. Guo, R. Chen, D. Zhou, pH and nearinfrared light dual-stimuli responsive drug delivery using DNA-conjugated gold nanorods for effective treatment of multidrug resistant cancer cells, J. Control. Release 232(28) (2016) 9-19.
[52] Y. Li, J. Jin, D. Wang, J. Lv, K. Hou, Y. Liu, C. Chen, Z. Tang, Coordination-responsive drug release inside gold nanorod@metal-organic framework core-shell nanostructures for near-infrared-induced synergistic chemo-photothermal therapy, Nano Res. 11(6) (2017) 3294-3305.
[53] Z. Zhang, J. Wang, X. Nie, T. Wen, Y. Ji, X. Wu, Y. Zhao, C. Chen, Near infrared laserinduced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods, J. Am. Chem. Soc. 136(20) (2014) 7317-7326.
[54] W. Yao, H. Zhou, Y. Lu, Synthesis and property of novel MnO₂@polypyrrole coaxial nanotubes as electrode material for supercapacitors, J. Power Sources 241(2013) 359-366.
[55] C.A. Choi, J.E. Lee, Z.A.I. Mazrad, I. In, J.H. Jeong, S.Y. Park, Redox-and pH-responsive fluorescent carbon nanoparticles-MnO₂-based FRET system for tumor-targeted drug delivery in vivo and in vitro, J. Ind. Eng. Chem. 63(2018) 208-219.
[56] F. Wang, H.X. Dai, J.G. Deng, G.M. Bai, K.M. Ji, Y.X. Liu, Manganese oxides with rod-, wire-, tube-, and flower-like morphologies:highly effective catalysts for the removal of toluene, Environ. Sci. Technol. 46(7) (2012) 4034-4041.
[57] J.M. Li, Z.P. Qu, Y. Qin, H. Wang, Effect of MnO₂ morphology on the catalytic oxidation of toluene over Ag/MnO₂ catalysts, Appl. Surf. Sci. 385(2016) 234-240.
[58] L. Guo, Y. Zhang, Z.P. Yang, H. Peng, R.X. Wei, C.F. Wang, M. Feng, Tunneling nanotubular expressways for ultrafast and accurate M1 macrophage delivery of anticancer drugs to metastatic ovarian carcinoma, ACS Nano 13(2) (2019) 1078-1096.
[59] P. Ritger, N. Peppas, A simple equation for description of solute release II. Fickian and anomalous release from swellable devices, J. Control. Release 5(1) (1987) 37-42.
[60] S.H. Xu, J. Shi, D.S. Feng, L. Yang, S.K. Cao, Hollow hierarchical hydroxyapatite/au/polyelectrolyte hybrid microparticles for multi-responsive drug delivery, J. Mater. Chem. B 2(38) (2014) 6500-6507.
[61] X.Y. Zhu, J. Shi, H. Ma, R.X. Chen, J.G. Li, S.K. Cao, Hierarchical hydroxyapatite/polyelectrolyte microcapsules capped with AuNRs for remotely triggered drug delivery, Mater. Sci. Eng. C. 99(2019) 1236-1245.

Hollow MnO₂/GNPs serving as a multiresponsive nanocarrier for controlled drug release

Hollow MnO₂/GNPs serving as a multiresponsive nanocarrier for controlled drug release

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