中国化学工程学报 ›› 2020, Vol. 28 ›› Issue (11): 2837-2847.DOI: 10.1016/j.cjche.2020.05.035
• Special Topic: Biocatalysis • 上一篇 下一篇
Qianqian Hou, Nanxing Li, Yuanyuan Chao, Shihao Li, Lin Zhang
收稿日期:2020-02-28
修回日期:2020-05-28
出版日期:2020-11-28
发布日期:2020-12-31
通讯作者:
Lin Zhang
基金资助:Qianqian Hou, Nanxing Li, Yuanyuan Chao, Shihao Li, Lin Zhang
Received:2020-02-28
Revised:2020-05-28
Online:2020-11-28
Published:2020-12-31
Contact:
Lin Zhang
Supported by:摘要： Surface and interfacial behavior of protein molecules are crucial for the protein function involved in many biochemical processes and biomedical products such as enzyme design, bio-separation, drug design and delivery. This article is devoted to an overview of design and regulation of the surface and interfacial behavior of protein molecules. The improvement of enzyme surface such as the directed evolution and the rational design of enzymes is introduced at first, followed by the rational design of protein interface for the protein assembly. Thereafter, the design of micro-environment and ligands are described as two examples for the design guided by protein surface. Then the design of protein surface and interface with the help of artificial intelligence will be discussed.
Qianqian Hou, Nanxing Li, Yuanyuan Chao, Shihao Li, Lin Zhang. Design and regulation of the surface and interfacial behavior of protein molecules[J]. 中国化学工程学报, 2020, 28(11): 2837-2847.
Qianqian Hou, Nanxing Li, Yuanyuan Chao, Shihao Li, Lin Zhang. Design and regulation of the surface and interfacial behavior of protein molecules[J]. Chinese Journal of Chemical Engineering, 2020, 28(11): 2837-2847.
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