Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains

doi:10.1016/j.cjche.2020.12.004

中国化学工程学报 ›› 2021, Vol. 29 ›› Issue (2): 178-184.DOI: 10.1016/j.cjche.2020.12.004

• Biocatalysis and Bioreactor Engineering • 上一篇下一篇

Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains

Jianye Xia, Guan Wang, Meng Fan, Min Chen, Zeyu Wang, Yingping Zhuang

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China

收稿日期:2020-10-18 修回日期:2020-12-03 出版日期:2021-02-28 发布日期:2021-05-15
通讯作者: Yingping Zhuang
基金资助:
The authors would like to acknowledge the Projects 21776082 and 21978085 supported by National Natural Science Foundation of China, and Project 22221818014 supported by the Fundamental Research Funds for the Central Universities.

Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains

Jianye Xia, Guan Wang, Meng Fan, Min Chen, Zeyu Wang, Yingping Zhuang

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China

Received:2020-10-18 Revised:2020-12-03 Online:2021-02-28 Published:2021-05-15
Contact: Yingping Zhuang
Supported by:
The authors would like to acknowledge the Projects 21776082 and 21978085 supported by National Natural Science Foundation of China, and Project 22221818014 supported by the Fundamental Research Funds for the Central Universities.

摘要/Abstract

摘要： The production capability of a fermentation process is predominately determined by individual strains, which ultimately affected ultimately by interactions between the scale-dependent flow field developed within bioreactors and the physiological response of these strains. Interpreting these complicated interactions is key for better understanding the scale-up of the fermentation process. We review these two aspects and address progress in strategies for scaling up fermentation processes. A perspective on how to incorporate the multiomics big data into the scale-up strategy is presented to improve the design and operation of industrial fermentation processes.

关键词: Fermentation, Scale-up, Bioreactors, Gas–liquid flow, Kinetics

Abstract: The production capability of a fermentation process is predominately determined by individual strains, which ultimately affected ultimately by interactions between the scale-dependent flow field developed within bioreactors and the physiological response of these strains. Interpreting these complicated interactions is key for better understanding the scale-up of the fermentation process. We review these two aspects and address progress in strategies for scaling up fermentation processes. A perspective on how to incorporate the multiomics big data into the scale-up strategy is presented to improve the design and operation of industrial fermentation processes.

Key words: Fermentation, Scale-up, Bioreactors, Gas–liquid flow, Kinetics

Jianye Xia, Guan Wang, Meng Fan, Min Chen, Zeyu Wang, Yingping Zhuang. Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains[J]. 中国化学工程学报, 2021, 29(2): 178-184.

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Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains

Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains

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