SCI和EI收录∣中国化工学会会刊

中国化学工程学报 ›› 2022, Vol. 48 ›› Issue (8): 244-252.DOI: 10.1016/j.cjche.2021.08.025

• • 上一篇    

Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers

Baolong Niu1,2, Min Li1,2, Jianhong Jia1,2, Lixuan Ren1,2, Xin Gang1,2, Bin Nie1,2, Yanying Fan5, Xiaojie Lian3,4, Wenfeng Li1,2   

  1. 1. College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China;
    2. Key Laboratory of Interface Science and Engineering in Advanced Materials, Taiyuan University of Technology, Taiyuan 030024, China;
    3. Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China;
    4. Shanxi Key Laboratory of Material Strength & Structural Impact, Institute of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China;
    5. School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China
  • 收稿日期:2021-01-23 修回日期:2021-08-29 出版日期:2022-08-28 发布日期:2022-09-30
  • 通讯作者: Baolong Niu,E-mail:baolongniutyut@hotmail.com;Wenfeng Li,E-mail:wenfenglityut@live.com
  • 基金资助:
    The work was financially supported by the National Natural Science Foundation of China (31700689), Natural Science Foundation of Shanxi Province (201901D111115), Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi (172040098-S), and Transformation of Scientific and Technological Achievements Programs of Higher Education Institutions in Shanxi (2020CG015).

Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers

Baolong Niu1,2, Min Li1,2, Jianhong Jia1,2, Lixuan Ren1,2, Xin Gang1,2, Bin Nie1,2, Yanying Fan5, Xiaojie Lian3,4, Wenfeng Li1,2   

  1. 1. College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China;
    2. Key Laboratory of Interface Science and Engineering in Advanced Materials, Taiyuan University of Technology, Taiyuan 030024, China;
    3. Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China;
    4. Shanxi Key Laboratory of Material Strength & Structural Impact, Institute of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China;
    5. School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China
  • Received:2021-01-23 Revised:2021-08-29 Online:2022-08-28 Published:2022-09-30
  • Contact: Baolong Niu,E-mail:baolongniutyut@hotmail.com;Wenfeng Li,E-mail:wenfenglityut@live.com
  • Supported by:
    The work was financially supported by the National Natural Science Foundation of China (31700689), Natural Science Foundation of Shanxi Province (201901D111115), Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi (172040098-S), and Transformation of Scientific and Technological Achievements Programs of Higher Education Institutions in Shanxi (2020CG015).

摘要: Recently, multifunctional nanoparticles have shown great prospects in cancer treatment, which have the ability to simultaneously deliver the drug, image and target tumor cells. In this paper, we designed a luminescent nanoparticles platform based on hydrothermal hyaluronic acid/amorphous calcium phosphate (HA-FCNs/ACP) with multifunctional properties for drug delivery, bio-imaging, and targeting treatment. HA-FCNs/ACP shows an ability to load curcumin (Cur) with pH-sensitive responsive drug release behavior and excellent biocompatibility. HA-FCNs/ACP dispersed in the cytoplasm through the overexpressed CD44 receptor that is actively targeted into human lung cancer cells (A549 cells). Meanwhile, the viability of A549 cells was significantly inhibited in vitro. The prepared HA-FCNs and HA-FCNs/ACP both exhibit excellent targeted bioimaging performance on cancer cells. Hence, the as-prepared nanoparticles have promising applications in treating tumor disease.

关键词: Hyaluronic acid, Amorphous calcium phosphate, Fluorescent carbon nanoparticles, pH-sensitive, Tumor targeting

Abstract: Recently, multifunctional nanoparticles have shown great prospects in cancer treatment, which have the ability to simultaneously deliver the drug, image and target tumor cells. In this paper, we designed a luminescent nanoparticles platform based on hydrothermal hyaluronic acid/amorphous calcium phosphate (HA-FCNs/ACP) with multifunctional properties for drug delivery, bio-imaging, and targeting treatment. HA-FCNs/ACP shows an ability to load curcumin (Cur) with pH-sensitive responsive drug release behavior and excellent biocompatibility. HA-FCNs/ACP dispersed in the cytoplasm through the overexpressed CD44 receptor that is actively targeted into human lung cancer cells (A549 cells). Meanwhile, the viability of A549 cells was significantly inhibited in vitro. The prepared HA-FCNs and HA-FCNs/ACP both exhibit excellent targeted bioimaging performance on cancer cells. Hence, the as-prepared nanoparticles have promising applications in treating tumor disease.

Key words: Hyaluronic acid, Amorphous calcium phosphate, Fluorescent carbon nanoparticles, pH-sensitive, Tumor targeting