Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers

doi:10.1016/j.cjche.2021.08.025

中国化学工程学报 ›› 2022, Vol. 48 ›› Issue (8): 244-252.DOI: 10.1016/j.cjche.2021.08.025

Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers

Baolong Niu^1,2, Min Li^1,2, Jianhong Jia^1,2, Lixuan Ren^1,2, Xin Gang^1,2, Bin Nie^1,2, Yanying Fan⁵, Xiaojie Lian^3,4, Wenfeng Li^1,2

1. College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China;
2. Key Laboratory of Interface Science and Engineering in Advanced Materials, Taiyuan University of Technology, Taiyuan 030024, China;
3. Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China;
4. Shanxi Key Laboratory of Material Strength & Structural Impact, Institute of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China;
5. School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China

收稿日期:2021-01-23 修回日期:2021-08-29 出版日期:2022-08-28 发布日期:2022-09-30
通讯作者: Baolong Niu,E-mail:baolongniutyut@hotmail.com;Wenfeng Li,E-mail:wenfenglityut@live.com
基金资助:
The work was financially supported by the National Natural Science Foundation of China (31700689), Natural Science Foundation of Shanxi Province (201901D111115), Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi (172040098-S), and Transformation of Scientific and Technological Achievements Programs of Higher Education Institutions in Shanxi (2020CG015).

Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers

Baolong Niu^1,2, Min Li^1,2, Jianhong Jia^1,2, Lixuan Ren^1,2, Xin Gang^1,2, Bin Nie^1,2, Yanying Fan⁵, Xiaojie Lian^3,4, Wenfeng Li^1,2

1. College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China;
2. Key Laboratory of Interface Science and Engineering in Advanced Materials, Taiyuan University of Technology, Taiyuan 030024, China;
3. Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China;
4. Shanxi Key Laboratory of Material Strength & Structural Impact, Institute of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China;
5. School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China

Received:2021-01-23 Revised:2021-08-29 Online:2022-08-28 Published:2022-09-30
Contact: Baolong Niu,E-mail:baolongniutyut@hotmail.com;Wenfeng Li,E-mail:wenfenglityut@live.com
Supported by:
The work was financially supported by the National Natural Science Foundation of China (31700689), Natural Science Foundation of Shanxi Province (201901D111115), Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi (172040098-S), and Transformation of Scientific and Technological Achievements Programs of Higher Education Institutions in Shanxi (2020CG015).

摘要/Abstract

摘要： Recently, multifunctional nanoparticles have shown great prospects in cancer treatment, which have the ability to simultaneously deliver the drug, image and target tumor cells. In this paper, we designed a luminescent nanoparticles platform based on hydrothermal hyaluronic acid/amorphous calcium phosphate (HA-FCNs/ACP) with multifunctional properties for drug delivery, bio-imaging, and targeting treatment. HA-FCNs/ACP shows an ability to load curcumin (Cur) with pH-sensitive responsive drug release behavior and excellent biocompatibility. HA-FCNs/ACP dispersed in the cytoplasm through the overexpressed CD44 receptor that is actively targeted into human lung cancer cells (A549 cells). Meanwhile, the viability of A549 cells was significantly inhibited in vitro. The prepared HA-FCNs and HA-FCNs/ACP both exhibit excellent targeted bioimaging performance on cancer cells. Hence, the as-prepared nanoparticles have promising applications in treating tumor disease.

关键词: Hyaluronic acid, Amorphous calcium phosphate, Fluorescent carbon nanoparticles, pH-sensitive, Tumor targeting

Abstract: Recently, multifunctional nanoparticles have shown great prospects in cancer treatment, which have the ability to simultaneously deliver the drug, image and target tumor cells. In this paper, we designed a luminescent nanoparticles platform based on hydrothermal hyaluronic acid/amorphous calcium phosphate (HA-FCNs/ACP) with multifunctional properties for drug delivery, bio-imaging, and targeting treatment. HA-FCNs/ACP shows an ability to load curcumin (Cur) with pH-sensitive responsive drug release behavior and excellent biocompatibility. HA-FCNs/ACP dispersed in the cytoplasm through the overexpressed CD44 receptor that is actively targeted into human lung cancer cells (A549 cells). Meanwhile, the viability of A549 cells was significantly inhibited in vitro. The prepared HA-FCNs and HA-FCNs/ACP both exhibit excellent targeted bioimaging performance on cancer cells. Hence, the as-prepared nanoparticles have promising applications in treating tumor disease.

Key words: Hyaluronic acid, Amorphous calcium phosphate, Fluorescent carbon nanoparticles, pH-sensitive, Tumor targeting

Baolong Niu, Min Li, Jianhong Jia, Lixuan Ren, Xin Gang, Bin Nie, Yanying Fan, Xiaojie Lian, Wenfeng Li. Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers[J]. 中国化学工程学报, 2022, 48(8): 244-252.

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Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers

Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers

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