SCI和EI收录∣中国化工学会会刊

›› 2009, Vol. 17 ›› Issue (2): 318-323.

• • 上一篇    下一篇

Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation(HGAP) Method

赵宏1, 王洁欣1, 张海霞1, 沈志刚1,2, 甄崇礼2, 陈建峰1   

  1. 1. Sin-China Nano Technology Center, Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 10029, China;
    2. Nanomaterials Technology Pte. Ltd., Singapore
  • 收稿日期:2008-09-03 修回日期:2008-11-11 出版日期:2009-04-28 发布日期:2009-04-28
  • 通讯作者: CHEN Jianfeng,E-mail:chenjf@mail.buct.edu.cn
  • 基金资助:
    Supported by the National High Technology Research and Development Program of China (2006AA030202);the Talent Training Program of Beijing (2007B022)

Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation(HGAP) Method

ZHAO Hong1, WANG Jiexin1, ZHANG Haixia1, SHEN Zhigang1,2, Jimmy Yun2, CHEN Jianfeng1   

  1. 1. Sin-China Nano Technology Center, Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 10029, China;
    2. Nanomaterials Technology Pte. Ltd., Singapore
  • Received:2008-09-03 Revised:2008-11-11 Online:2009-04-28 Published:2009-04-28
  • Supported by:
    Supported by the National High Technology Research and Development Program of China (2006AA030202);the Talent Training Program of Beijing (2007B022)

摘要: The nanoparticles of the hydrophobic drug of danazol with narrow size distribution are facilely prepared by controlled high-gravity anti-solvent precipitation(HGAP) process.Intensified micromixing and uniform nucleation environment are created by the high-gravity equipment(rotating packed bed) in carrying out the anti-solvent precipitation process to produce nanoparticles.The average particle size decreases from 55 μm of the raw danazol to 190 nm of the nanoparticles.The Brunauer-Emmett-Teller(BET) surface area sharply increases from 0.66 m2·g-1 to 15.08 m2·g-1.Accordingly,the dissolution rate is greatly improved.The molecular state,chemical composition,and crystal form of the danazol nanoparticles remains unchanged after processing according to Fourier transform infrared(FTIR) and X-ray diffraction(XRD).The high recovery ratio and continuous production capacity are highly appreciated in industry.Therefore,the HGAP method might offer a general and facile platform for mass production of hydrophobic pharmaceutical danazol particles in nanometer range.

关键词: high-gravity antisolvent precipitation,rotating packed bed, danazol,nanoparticles,dissolution rate

Abstract: The nanoparticles of the hydrophobic drug of danazol with narrow size distribution are facilely prepared by controlled high-gravity anti-solvent precipitation(HGAP) process.Intensified micromixing and uniform nucleation environment are created by the high-gravity equipment(rotating packed bed) in carrying out the anti-solvent precipitation process to produce nanoparticles.The average particle size decreases from 55 μm of the raw danazol to 190 nm of the nanoparticles.The Brunauer-Emmett-Teller(BET) surface area sharply increases from 0.66 m2·g-1 to 15.08 m2·g-1.Accordingly,the dissolution rate is greatly improved.The molecular state,chemical composition,and crystal form of the danazol nanoparticles remains unchanged after processing according to Fourier transform infrared(FTIR) and X-ray diffraction(XRD).The high recovery ratio and continuous production capacity are highly appreciated in industry.Therefore,the HGAP method might offer a general and facile platform for mass production of hydrophobic pharmaceutical danazol particles in nanometer range.

Key words: high-gravity antisolvent precipitation,rotating packed bed, danazol,nanoparticles,dissolution rate