Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects

doi:10.1016/j.cjche.2016.01.003

Chinese Journal of Chemical Engineering ›› 2016, Vol. 24 ›› Issue (4): 513-520.DOI: 10.1016/j.cjche.2016.01.003

• 第25届中国过程控制会议专栏 • 上一篇下一篇

Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects

Anca-Irina Galaction¹, Dan Cascaval², Ramona-MihaelaMatran², Alexandra Tucaliuc²

1 "Grigore T. Popa" University of Medicine and Pharmacy of Iasi, Faculty of Medical Bioengineering, Dept. of Biomedical Science, M. Kogalniceanu 9-13, 700454 Iasi, Romania;
2 "Gheorghe Asachi" Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, Dept. of Biochemical Engineering, D. Mangeron 73, 700050 Iasi, Romania

收稿日期:2015-02-03 修回日期:2015-05-11 出版日期:2016-04-28 发布日期:2016-05-27
通讯作者: Dan Cascaval
基金资助:
Supported by the Grant PN-II-PT-PCCA-2011-3.1-1268 authorized by The National Council for Scientific Research-Executive Unit for Financing Higher Education, Research, Development and Innovation (CNCS-UEFISCDI).

Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects

Anca-Irina Galaction¹, Dan Cascaval², Ramona-MihaelaMatran², Alexandra Tucaliuc²

1 "Grigore T. Popa" University of Medicine and Pharmacy of Iasi, Faculty of Medical Bioengineering, Dept. of Biomedical Science, M. Kogalniceanu 9-13, 700454 Iasi, Romania;
2 "Gheorghe Asachi" Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, Dept. of Biochemical Engineering, D. Mangeron 73, 700050 Iasi, Romania

Received:2015-02-03 Revised:2015-05-11 Online:2016-04-28 Published:2016-05-27
Contact: Dan Cascaval
Supported by:
Supported by the Grant PN-II-PT-PCCA-2011-3.1-1268 authorized by The National Council for Scientific Research-Executive Unit for Financing Higher Education, Research, Development and Innovation (CNCS-UEFISCDI).

摘要/Abstract

摘要： The glucose mass transfer in the biosynthesis of succinic acid with immobilized Actinobacillus succinogenes cells has been comparatively analyzed for a bioreactor with mobile bed vs. a stationary basket bioreactor. The process has been considered to occur under substrate and product inhibitory effects. The results indicated that the bioreactor withmobile bed is more efficient for biocatalyst particles with a diameter over 3mm,while the basket bioreactor ismore efficient for smaller biocatalyst particles and basket bed thickness below 5mm. The performances of both configurations of immobilized A. succinogenes cell beds were found to be superior to the column packed bed bioreactor.

关键词: Mass transfer, Diffusion, Stirred vessel, Immobilized cells, Basket bioreactor, Succinic acid

Abstract: The glucose mass transfer in the biosynthesis of succinic acid with immobilized Actinobacillus succinogenes cells has been comparatively analyzed for a bioreactor with mobile bed vs. a stationary basket bioreactor. The process has been considered to occur under substrate and product inhibitory effects. The results indicated that the bioreactor withmobile bed is more efficient for biocatalyst particles with a diameter over 3mm,while the basket bioreactor ismore efficient for smaller biocatalyst particles and basket bed thickness below 5mm. The performances of both configurations of immobilized A. succinogenes cell beds were found to be superior to the column packed bed bioreactor.

Key words: Mass transfer, Diffusion, Stirred vessel, Immobilized cells, Basket bioreactor, Succinic acid

Anca-Irina Galaction, Dan Cascaval, Ramona-MihaelaMatran, Alexandra Tucaliuc. Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects[J]. Chinese Journal of Chemical Engineering, 2016, 24(4): 513-520.

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Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects

Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects

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