Design and optimization of purification process of sinomenine hydrochloride

doi:10.1016/j.cjche.2022.04.022

中国化学工程学报 ›› 2023, Vol. 55 ›› Issue (3): 63-72.DOI: 10.1016/j.cjche.2022.04.022

• Full Length Article • 上一篇下一篇

Design and optimization of purification process of sinomenine hydrochloride

Dandan Ren^1,2, Shanshan Xiang¹, Yuwen Yan¹, Ruiying Kong¹, Xingchu Gong^1,2,3

1. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China;
2. Innovation Center in Zhejiang University, State Key Laboratory of Component-Based Chinese Medicine, Hangzhou 310058, China;
3. Jinhua Institute of Zhejiang University, Jinhua 321016, China

收稿日期:2022-02-08 修回日期:2022-04-28 出版日期:2023-03-28 发布日期:2023-06-03
通讯作者: Xingchu Gong,E-mail:gongxingchu@zju.edu.cn
基金资助:
This work was supported by the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (ZYYCXTD-D-202002) and the National Project for Standardization of Chinese Materia Medica (ZYBZH‐C‐GD‐04).

Design and optimization of purification process of sinomenine hydrochloride

Dandan Ren^1,2, Shanshan Xiang¹, Yuwen Yan¹, Ruiying Kong¹, Xingchu Gong^1,2,3

1. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China;
2. Innovation Center in Zhejiang University, State Key Laboratory of Component-Based Chinese Medicine, Hangzhou 310058, China;
3. Jinhua Institute of Zhejiang University, Jinhua 321016, China

Received:2022-02-08 Revised:2022-04-28 Online:2023-03-28 Published:2023-06-03
Contact: Xingchu Gong,E-mail:gongxingchu@zju.edu.cn
Supported by:
This work was supported by the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (ZYYCXTD-D-202002) and the National Project for Standardization of Chinese Materia Medica (ZYBZH‐C‐GD‐04).

摘要/Abstract

摘要： Sinomenine hydrochloride is generally produced from Caulis Sinomenii. At present, the purification process in industrial production suffers from large amount of solid waste, high solvent toxicity, and low sinomenine hydrochloride yield. In this study, a new purification process for sinomenine hydrochloride was proposed by using the extract obtained from acid extraction of Caulis Sinomenii as the starting material. The process included the following steps: alkalization, extraction, water washing, acid–water stripping, drying, and crystallization. 1-Heptanol was used as the extractant. The distribution coefficients of sinomenine and sinomenine hydrochloride in 1-heptanol–water system were 27.4 and 0.0167, respectively. The dissociation constants of sinomenine hydrochloride were 8.27 and 11.24, respectively. Process parameters of the new purification process were optimized with experimental design. The extractant 1-heptanol and sinomenine hydrochloride in the crystallization mother solution can be recycled in the new process. The purity of the obtained sinomenine hydrochloride crystals exceeded 85%, and the yield was about 70%. Compared with current industrial processes, safer extractant, less solid waste, and higher sinomenine hydrochloride yield can be achieved using the new purification process of sinomenine hydrochloride provided in this study.

关键词: Sinomenine hydrochloride, Process optimization, Extraction, Crystallization, 1-Heptanol

Abstract: Sinomenine hydrochloride is generally produced from Caulis Sinomenii. At present, the purification process in industrial production suffers from large amount of solid waste, high solvent toxicity, and low sinomenine hydrochloride yield. In this study, a new purification process for sinomenine hydrochloride was proposed by using the extract obtained from acid extraction of Caulis Sinomenii as the starting material. The process included the following steps: alkalization, extraction, water washing, acid–water stripping, drying, and crystallization. 1-Heptanol was used as the extractant. The distribution coefficients of sinomenine and sinomenine hydrochloride in 1-heptanol–water system were 27.4 and 0.0167, respectively. The dissociation constants of sinomenine hydrochloride were 8.27 and 11.24, respectively. Process parameters of the new purification process were optimized with experimental design. The extractant 1-heptanol and sinomenine hydrochloride in the crystallization mother solution can be recycled in the new process. The purity of the obtained sinomenine hydrochloride crystals exceeded 85%, and the yield was about 70%. Compared with current industrial processes, safer extractant, less solid waste, and higher sinomenine hydrochloride yield can be achieved using the new purification process of sinomenine hydrochloride provided in this study.

Key words: Sinomenine hydrochloride, Process optimization, Extraction, Crystallization, 1-Heptanol

Dandan Ren, Shanshan Xiang, Yuwen Yan, Ruiying Kong, Xingchu Gong. Design and optimization of purification process of sinomenine hydrochloride[J]. 中国化学工程学报, 2023, 55(3): 63-72.

Dandan Ren, Shanshan Xiang, Yuwen Yan, Ruiying Kong, Xingchu Gong. Design and optimization of purification process of sinomenine hydrochloride[J]. Chinese Journal of Chemical Engineering, 2023, 55(3): 63-72.

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Design and optimization of purification process of sinomenine hydrochloride

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