Assessing mixing uniformity in microreactors via in-line spectroscopy

doi:10.1016/j.cjche.2023.09.009

中国化学工程学报 ›› 2024, Vol. 66 ›› Issue (2): 119-124.DOI: 10.1016/j.cjche.2023.09.009

• Full Length Article • 上一篇下一篇

Assessing mixing uniformity in microreactors via in-line spectroscopy

Shusaku Asano¹, Shinji Kudo¹, Taisuke Maki², Yosuke Muranaka², Kazuhiro Mae², Jun-ichiro Hayashi¹

1. Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga 816-8580, Japan;
2. Department of Chemical Engineering, Graduate School of Engineering, Kyoto University, Japan

收稿日期:2023-07-22 修回日期:2023-09-15 出版日期:2024-02-28 发布日期:2024-04-20
通讯作者: Shusaku Asano,E-mail:shusaku_asano@cm.kyushu-u.ac.jp
基金资助:
SA and SK acknowledge the support of JSPS KAKENHI (21H05083) and the Cooperative Research Program of the Network Joint Research Center for Materials and Devices, which was supported by the Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan. SA and YM acknowledge support fromAUN/SEED-Net (BUU REd-UC 2301) for Research and Education Grant for the University Consortium (consortium name: CES-CHEM).

Assessing mixing uniformity in microreactors via in-line spectroscopy

Shusaku Asano¹, Shinji Kudo¹, Taisuke Maki², Yosuke Muranaka², Kazuhiro Mae², Jun-ichiro Hayashi¹

1. Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga 816-8580, Japan;
2. Department of Chemical Engineering, Graduate School of Engineering, Kyoto University, Japan

Received:2023-07-22 Revised:2023-09-15 Online:2024-02-28 Published:2024-04-20
Contact: Shusaku Asano,E-mail:shusaku_asano@cm.kyushu-u.ac.jp
Supported by:
SA and SK acknowledge the support of JSPS KAKENHI (21H05083) and the Cooperative Research Program of the Network Joint Research Center for Materials and Devices, which was supported by the Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan. SA and YM acknowledge support fromAUN/SEED-Net (BUU REd-UC 2301) for Research and Education Grant for the University Consortium (consortium name: CES-CHEM).

摘要/Abstract

摘要： Mixing behavior is critical for enhancing the selectivity of fast chemical reactions in microreactors. A high Reynolds number (Re) improves the mixing rate and selectivity of the reactions, but some exceptions of increasing side product yield with the higher Re have been reported. This study investigated the mixing uniformity in microreactors with in-line UV–vis spectroscopy to clarify the relationship between reaction selectivity and chaotic mixing with the higher Re. A colorization experiment of thymolphthalein in an acidic solution was conducted with an excess acid amount to the base to indicate a non-uniformly mixed region. Non-uniformity significantly increased with Re. At the same time, the degree of mixing, which was measured by a usual decolorization experiment, showed that the mixing rate increased with Re. The in-line analysis of the Villermaux–Dushman reaction during the mixing clarified that side product yield significantly increased with Re at around 300 and then decreased at around 1100. These results suggest the compensation effect between the mixing uniformity and mixing rate on the selectivity of the mixing-sensitive reactions. Faster mixing, characterized by a larger Re, can disturb mixing uniformity and, in some cases, decrease reaction selectivity.

关键词: Microreactor, Villermaux–Dushman reaction, In-line analysis, Mixing, Mass transfer, Uniformity

Abstract: Mixing behavior is critical for enhancing the selectivity of fast chemical reactions in microreactors. A high Reynolds number (Re) improves the mixing rate and selectivity of the reactions, but some exceptions of increasing side product yield with the higher Re have been reported. This study investigated the mixing uniformity in microreactors with in-line UV–vis spectroscopy to clarify the relationship between reaction selectivity and chaotic mixing with the higher Re. A colorization experiment of thymolphthalein in an acidic solution was conducted with an excess acid amount to the base to indicate a non-uniformly mixed region. Non-uniformity significantly increased with Re. At the same time, the degree of mixing, which was measured by a usual decolorization experiment, showed that the mixing rate increased with Re. The in-line analysis of the Villermaux–Dushman reaction during the mixing clarified that side product yield significantly increased with Re at around 300 and then decreased at around 1100. These results suggest the compensation effect between the mixing uniformity and mixing rate on the selectivity of the mixing-sensitive reactions. Faster mixing, characterized by a larger Re, can disturb mixing uniformity and, in some cases, decrease reaction selectivity.

Key words: Microreactor, Villermaux–Dushman reaction, In-line analysis, Mixing, Mass transfer, Uniformity

Shusaku Asano, Shinji Kudo, Taisuke Maki, Yosuke Muranaka, Kazuhiro Mae, Jun-ichiro Hayashi. Assessing mixing uniformity in microreactors via in-line spectroscopy[J]. 中国化学工程学报, 2024, 66(2): 119-124.

Shusaku Asano, Shinji Kudo, Taisuke Maki, Yosuke Muranaka, Kazuhiro Mae, Jun-ichiro Hayashi. Assessing mixing uniformity in microreactors via in-line spectroscopy[J]. Chinese Journal of Chemical Engineering, 2024, 66(2): 119-124.

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Assessing mixing uniformity in microreactors via in-line spectroscopy

Assessing mixing uniformity in microreactors via in-line spectroscopy

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