Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures

doi:10.1016/j.cjche.2017.05.002

›› 2017, Vol. 25 ›› Issue (10): 1461-1466.DOI: 10.1016/j.cjche.2017.05.002

• Chemical Engineering Thermodynamics • 上一篇下一篇

Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures

Lina Zhou^1,2, Shichao Du^1,2, Ting Wang^1,2, Songgu Wu^1,2, Zhiqiang Guo³, Zhao Wang^1,2, Ling Zhou^1,2

1 School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China;
2 The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Tianjin 300072, China;
3 Tianjin Pharmaceuticals Research Institute Co. Ltd, Tianjin 300000, China

收稿日期:2016-08-30 修回日期:2017-05-16 出版日期:2017-10-28 发布日期:2017-11-15
通讯作者: Ling Zhou,E-mail address:zhouling@tju.edu.cn
基金资助:
Supported by Tianjin Municipal Natural Science Foundation (16JCYBJC19500) and China Ministry of Science and Major National Scientific Instrument Development Project (2016YFF0102503).

Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures

Lina Zhou^1,2, Shichao Du^1,2, Ting Wang^1,2, Songgu Wu^1,2, Zhiqiang Guo³, Zhao Wang^1,2, Ling Zhou^1,2

1 School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China;
2 The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Tianjin 300072, China;
3 Tianjin Pharmaceuticals Research Institute Co. Ltd, Tianjin 300000, China

Received:2016-08-30 Revised:2017-05-16 Online:2017-10-28 Published:2017-11-15
Supported by:
Supported by Tianjin Municipal Natural Science Foundation (16JCYBJC19500) and China Ministry of Science and Major National Scientific Instrument Development Project (2016YFF0102503).

摘要/Abstract

摘要： The solubility of meropenem trihydrate in water + acetone mixtures and water + tetrahydrofuran mixtures were determined from T=(278.15 to 303.15) K by static method under atmospheric pressure. Effects of solvent composition and temperature on solubility of meropenem trihydrate were discussed. To extend the applicability of the solubility data, experimental solubility data in two kinds of binary solvent mixtures were correlated by the Apelblat equation and NIBS/Redlich-Kister model. It was found that the two models could satisfactorily correlate the experimental data and the Apelblat equation could give better correlation results.

关键词: Solubility, Meropenem trihydrate, Thermodynamics

Abstract: The solubility of meropenem trihydrate in water + acetone mixtures and water + tetrahydrofuran mixtures were determined from T=(278.15 to 303.15) K by static method under atmospheric pressure. Effects of solvent composition and temperature on solubility of meropenem trihydrate were discussed. To extend the applicability of the solubility data, experimental solubility data in two kinds of binary solvent mixtures were correlated by the Apelblat equation and NIBS/Redlich-Kister model. It was found that the two models could satisfactorily correlate the experimental data and the Apelblat equation could give better correlation results.

Key words: Solubility, Meropenem trihydrate, Thermodynamics

Lina Zhou, Shichao Du, Ting Wang, Songgu Wu, Zhiqiang Guo, Zhao Wang, Ling Zhou. Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures[J]. , 2017, 25(10): 1461-1466.

参考文献

[1] Z. Sun, H. Hao, C. Xie, Z. Xu, Q. Yin, Y. Bao, B. Hou, Y. Wang, Thermodynamic properties of form A and form B of florfenicol, Ind. Eng. Chem. Res. 53(34) (2014) 13506-13512.
[2] X. Zhang, Q. Yin, P. Cui, Z. Liu, J. Gong, Correlation of solubilities of hydrophilic pharmaceuticals versus dielectric constants of binary solvents, Ind. Eng. Chem. Res. 51(19) (2012) 6933-6938.
[3] D. Bolen, Effects of naturally occurring osmolytes on protein stability and solubility:Issues important in protein crystallization, Methods 34(3) (2004) 312-322.
[4] P. Barrett, B. Glennon, Characterizing the metastable zone width and solubility curve using Lasentec FBRM and PVM, Chem. Eng. Res. Des. 80(7) (2002) 799-805.
[5] P. Paricaud, A. Galindo, G. Jackson, Modeling the cloud curves and the solubility of gases in amorphous and semicrystalline polyethylene with the SAFT-VR approach and Flory theory of crystallization, Ind. Eng. Chem. Res. 43(21) (2004) 6871-6889.
[6] J.E. Hugonnet, L.W. Tremblay, H.I. Boshoff, C.E. Barry, J.S. Blanchard, MeropenemClavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis, Science 323(5918) (2009) 1215-1218.
[7] J. Cielecka-Piontek, M. Zając, A. Jelińska, A comparison of the stability of ertapenem and meropenem in pharmaceutical preparations in solid state, J. Pharm. Biomed. 46(1) (2008) 52-57.
[8] A. Mendez, P. Chagastelles, E. Palma, N. Nardi, E. Schapoval, Thermal and alkaline stability of meropenem:Degradation products and cytotoxicity, Int. J. Pharm. 350(1) (2008) 95-102.
[9] A.S.L. Mendez, J. Dalomo, M. Steppe, E.E.S. Schapoval, Stability and degradation kinetics of meropenem in powder for injection and reconstituted sample, J. Pharm. Biomed. 41(4) (2006) 1363-1366.
[10] Y. Wei, X. Zhang, L. Dang, H. Wei, Solubility and pseudopolymorphic transitions in mixed solvent:Meropenem in methanol-water solution, Fluid Phase Equilib. 349(2013) 25-30.
[11] J. Zhang, J. Ouyang, H. Zhang, X. Huang, H. Hao, Y. Wang, Q. Yin, W. Fang, Solubility and thermodynamic functions of cefazolin acid in pure and mixed solvents at (278.15-308.15) K, Fluid Phase Equilib. 387(2015) 95-102.
[12] J. Li, Z. Wang, Y. Bao, J. Wang, Solid-liquid phase equilibrium and mixing properties of Cloxacillin Benzathine in pure and mixed solvents, Ind. Eng. Chem. Res. 52(8) (2013) 3019-3026.
[13] W.E. Acree, Mathematical representation of thermodynamic properties:Part 2. Derivation of the combined nearly ideal binary solvent (NIBS)/Redlich-Kister mathematical representation from a two-body and three-body interactional mixing model, Thermochim. Acta 198(1) (1992) 71-79.

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Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures

Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures

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