Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives

doi:10.1016/j.cjche.2018.06.003

Chinese Journal of Chemical Engineering ›› 2018, Vol. 26 ›› Issue (10): 2112-2120.DOI: 10.1016/j.cjche.2018.06.003

• Chemical Engineering Thermodynamics • 上一篇下一篇

Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives

Qiao Chen^1,2, Fengxia Zou^2,3, Pengpeng Yang^1,2, Jingwei Zhou^1,2, Jinglan Wu^1,2, Wei Zhuang^1,2, Hanjie Ying^1,2

1 State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 210009, China;
2 College of Biotechnology and Pharmaceutical Engineering, National Engineering Research Center for Biotechnology, Nanjing Tech University, Nanjing 210009, China;
3 College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China

收稿日期:2018-02-26 修回日期:2018-05-14 出版日期:2018-10-28 发布日期:2018-11-14
通讯作者: Wei Zhuang,E-mail addresses:weizhuang@njtech.edu.cn;Hanjie Ying,E-mail addresses:yinghanjie@njtech.edu.cn
基金资助:
Supported by the Program for Changjiang Scholars and Innovative Research Team in University (IRT_14R28), the National Basic Research Program of China (2013CB733602), the Major Research Plan of the National Natural Science Foundation of China (21390204), the National Natural Science Foundation of China (21636003, 21506090), Open Fund by Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals (JSBGFC14005), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives

Qiao Chen^1,2, Fengxia Zou^2,3, Pengpeng Yang^1,2, Jingwei Zhou^1,2, Jinglan Wu^1,2, Wei Zhuang^1,2, Hanjie Ying^1,2

1 State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 210009, China;
2 College of Biotechnology and Pharmaceutical Engineering, National Engineering Research Center for Biotechnology, Nanjing Tech University, Nanjing 210009, China;
3 College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China

Received:2018-02-26 Revised:2018-05-14 Online:2018-10-28 Published:2018-11-14
Contact: Wei Zhuang,E-mail addresses:weizhuang@njtech.edu.cn;Hanjie Ying,E-mail addresses:yinghanjie@njtech.edu.cn
Supported by:
Supported by the Program for Changjiang Scholars and Innovative Research Team in University (IRT_14R28), the National Basic Research Program of China (2013CB733602), the Major Research Plan of the National Natural Science Foundation of China (21390204), the National Natural Science Foundation of China (21636003, 21506090), Open Fund by Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals (JSBGFC14005), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

摘要/Abstract

摘要： Microstructure and phase transformation of disodium guanosine 5'-monophosphate (5'-GMPNa₂) are extremely important for controlling the process and understanding the mechanism of crystallization. In this work, the thermodynamic properties of polymorphous 5'-GMPNa₂ especially the solubility were studied, the solubility results show that 5'-GMPNa₂ is more soluble in ethanol-water (E-W) than in isopropanol-water (I-W). The amorphous form of 5'-GMPNa₂ is more soluble than the crystalline form at the same mole fraction and temperature. Meanwhile, the crystalline forms and morphologies of the residual solids were characterized by PXRD and SEM. The results indicate that solid forms of 5'-GMPNa₂ transformed spontaneously from amorphous to crystalline when the ethanol proportion is ≥ 20%. In addition, increasing the pH facilitates the dissolution of 5'-GMPNa₂ and helps to maintain the crystalline form. The associated Gibbs free energy values were calculated to verify the trend of transformation from amorphous to crystalline 5'-GMPNa₂. These results should help to guide the industrial crystallization process and to obtain the crystalline form of 5'-GMPNa₂.

关键词: Solid form transformation, Thermodynamics, Disodium guanosine 5'-monophosphate, Solubility, Crystallization, Intermolecular force

Abstract: Microstructure and phase transformation of disodium guanosine 5'-monophosphate (5'-GMPNa₂) are extremely important for controlling the process and understanding the mechanism of crystallization. In this work, the thermodynamic properties of polymorphous 5'-GMPNa₂ especially the solubility were studied, the solubility results show that 5'-GMPNa₂ is more soluble in ethanol-water (E-W) than in isopropanol-water (I-W). The amorphous form of 5'-GMPNa₂ is more soluble than the crystalline form at the same mole fraction and temperature. Meanwhile, the crystalline forms and morphologies of the residual solids were characterized by PXRD and SEM. The results indicate that solid forms of 5'-GMPNa₂ transformed spontaneously from amorphous to crystalline when the ethanol proportion is ≥ 20%. In addition, increasing the pH facilitates the dissolution of 5'-GMPNa₂ and helps to maintain the crystalline form. The associated Gibbs free energy values were calculated to verify the trend of transformation from amorphous to crystalline 5'-GMPNa₂. These results should help to guide the industrial crystallization process and to obtain the crystalline form of 5'-GMPNa₂.

Key words: Solid form transformation, Thermodynamics, Disodium guanosine 5'-monophosphate, Solubility, Crystallization, Intermolecular force

Qiao Chen, Fengxia Zou, Pengpeng Yang, Jingwei Zhou, Jinglan Wu, Wei Zhuang, Hanjie Ying. Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives[J]. Chinese Journal of Chemical Engineering, 2018, 26(10): 2112-2120.

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