SCI和EI收录∣中国化工学会会刊

中国化学工程学报 ›› 2021, Vol. 33 ›› Issue (5): 231-235.DOI: 10.1016/j.cjche.2020.09.054

• Chemical Engineering Thermodynamics • 上一篇    下一篇

Solubility measurement and thermodynamic modeling of carbamazepine (form III) in five pure solvents at various temperatures

Wenju Liu, Zehua Bao, Yanmin Shen, Tiantian Yao, Hongjuan Bai, Xinyu Jin   

  1. School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China
  • 收稿日期:2020-06-01 修回日期:2020-09-22 出版日期:2021-05-28 发布日期:2021-08-19
  • 通讯作者: Wenju Liu
  • 基金资助:
    The authors would like to thank the Science Foundation of Henan University of Technology (2017RCJH09, 2017QNJH29), Science Foundation of Henan Province (202102310208, 182102210399) for their financial assistance in this project.

Solubility measurement and thermodynamic modeling of carbamazepine (form III) in five pure solvents at various temperatures

Wenju Liu, Zehua Bao, Yanmin Shen, Tiantian Yao, Hongjuan Bai, Xinyu Jin   

  1. School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China
  • Received:2020-06-01 Revised:2020-09-22 Online:2021-05-28 Published:2021-08-19
  • Contact: Wenju Liu
  • Supported by:
    The authors would like to thank the Science Foundation of Henan University of Technology (2017RCJH09, 2017QNJH29), Science Foundation of Henan Province (202102310208, 182102210399) for their financial assistance in this project.

摘要: In this work, the solubilities of carbamazepine (CBZ) (form III) in ethyl acetate, methyl acetate, ethylene glycol, chloroform and cyclohexylamine were determined by laser monitoring techniques at pressure above sea level, and the solubility data of CBZ (form III) in different pure solvents were fitted by the Modified Apelblat model and λh model. The result shows that the solubility of CBZ (form III) in five solvents increases as temperature rises, and the solubility in chloroform was the largest. The experimental solubility values of CBZ (form III) in ethyl acetate, methyl acetate, chloroform and cyclohexylamine were in better agreement with the simulated fitting values of the λh model. For ethylene glycol, the r value was much larger than the other four solvents, and it can be seen from the λh model that ethylene glycol was closer to the ideal solution system than the other four solvents.

关键词: Solubility, Carbamazepine (form III), Modified Apelblat model, λh model

Abstract: In this work, the solubilities of carbamazepine (CBZ) (form III) in ethyl acetate, methyl acetate, ethylene glycol, chloroform and cyclohexylamine were determined by laser monitoring techniques at pressure above sea level, and the solubility data of CBZ (form III) in different pure solvents were fitted by the Modified Apelblat model and λh model. The result shows that the solubility of CBZ (form III) in five solvents increases as temperature rises, and the solubility in chloroform was the largest. The experimental solubility values of CBZ (form III) in ethyl acetate, methyl acetate, chloroform and cyclohexylamine were in better agreement with the simulated fitting values of the λh model. For ethylene glycol, the r value was much larger than the other four solvents, and it can be seen from the λh model that ethylene glycol was closer to the ideal solution system than the other four solvents.

Key words: Solubility, Carbamazepine (form III), Modified Apelblat model, λh model