Effect of impeller type and scale-up on spatial distribution of shear rate in a stirred tank

doi:10.1016/j.cjche.2021.03.004

中国化学工程学报 ›› 2022, Vol. 42 ›› Issue (2): 351-363.DOI: 10.1016/j.cjche.2021.03.004

Effect of impeller type and scale-up on spatial distribution of shear rate in a stirred tank

Huina Wang^1,2, Xiaoxia Duan^1,2, Xin Feng^1,2, Zai-Sha Mao¹, Chao Yang^1,2

1. CAS Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;
2. School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China

收稿日期:2021-01-07 修回日期:2021-03-01 出版日期:2022-02-28 发布日期:2022-03-30
通讯作者: Xiaoxia Duan,E-mail:xxduan@ipe.ac.cn;Chao Yang,E-mail:chaoyang@ipe.ac.cn
基金资助:
Financial support from National Key Research and Development Program (2020YFA0906800), the National Natural Science Foundation of China (21808221, 91934301, 21961160745), External Cooperation Program of BIC, Chinese Academy of Sciences (122111KYSB20190032), the Key Research Program of Nanjing IPE Institute of Green Manufacturing Industry (No. E0010719), and Innovation Academy for Green Manufacture, Chinese Academy of Sciences (IAGM2020C06) is gratefully acknowledged.

Effect of impeller type and scale-up on spatial distribution of shear rate in a stirred tank

Huina Wang^1,2, Xiaoxia Duan^1,2, Xin Feng^1,2, Zai-Sha Mao¹, Chao Yang^1,2

1. CAS Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;
2. School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China

Received:2021-01-07 Revised:2021-03-01 Online:2022-02-28 Published:2022-03-30
Contact: Xiaoxia Duan,E-mail:xxduan@ipe.ac.cn;Chao Yang,E-mail:chaoyang@ipe.ac.cn
Supported by:
Financial support from National Key Research and Development Program (2020YFA0906800), the National Natural Science Foundation of China (21808221, 91934301, 21961160745), External Cooperation Program of BIC, Chinese Academy of Sciences (122111KYSB20190032), the Key Research Program of Nanjing IPE Institute of Green Manufacturing Industry (No. E0010719), and Innovation Academy for Green Manufacture, Chinese Academy of Sciences (IAGM2020C06) is gratefully acknowledged.

摘要/Abstract

摘要： The main spatial distribution features of shear rate in a stirred tank operated with five different radial and axial flow impellers were presented with particle image velocimetry (PIV) experiments. Not only the average shear rate in the whole tank but also the local value in the vicinity of impeller increases linearly with impeller speed. Furthermore, the shear coefficient (K_s,imp) at the impeller outlet is linearly related to the impeller flow number (N_q) and decreases with the increase of N_q in general at the constant power consumption per unit volume (P_v). During scale-up based on the constant P_v and geometric similarity, CFD results show that the volume-averaged shear rate (γ_avg) for RDT decreases faster than that of other impellers with the impeller tip velocity (U_tip). The novel multi-blade combined (MBC) impeller with the increased height-to-diameter ratio of the stirred tank is able to more effectively improve the distribution uniformity of shear rate at the same P_v after scale-up. These studies provide a data basis for selecting the impeller types and improving the shear rate environment in the large-scale stirred tank.

关键词: Particle image velocimetry, Shear rate distribution, Constant power consumption per unit volume, Computational fluid dynamics, Scale-up

Abstract: The main spatial distribution features of shear rate in a stirred tank operated with five different radial and axial flow impellers were presented with particle image velocimetry (PIV) experiments. Not only the average shear rate in the whole tank but also the local value in the vicinity of impeller increases linearly with impeller speed. Furthermore, the shear coefficient (K_s,imp) at the impeller outlet is linearly related to the impeller flow number (N_q) and decreases with the increase of N_q in general at the constant power consumption per unit volume (P_v). During scale-up based on the constant P_v and geometric similarity, CFD results show that the volume-averaged shear rate (γ_avg) for RDT decreases faster than that of other impellers with the impeller tip velocity (U_tip). The novel multi-blade combined (MBC) impeller with the increased height-to-diameter ratio of the stirred tank is able to more effectively improve the distribution uniformity of shear rate at the same P_v after scale-up. These studies provide a data basis for selecting the impeller types and improving the shear rate environment in the large-scale stirred tank.

Key words: Particle image velocimetry, Shear rate distribution, Constant power consumption per unit volume, Computational fluid dynamics, Scale-up

Huina Wang, Xiaoxia Duan, Xin Feng, Zai-Sha Mao, Chao Yang. Effect of impeller type and scale-up on spatial distribution of shear rate in a stirred tank[J]. 中国化学工程学报, 2022, 42(2): 351-363.

Huina Wang, Xiaoxia Duan, Xin Feng, Zai-Sha Mao, Chao Yang. Effect of impeller type and scale-up on spatial distribution of shear rate in a stirred tank[J]. Chinese Journal of Chemical Engineering, 2022, 42(2): 351-363.

参考文献

[1] F. Garcia-Ochoa, E. Gomez,V.E. Santos, Fluid dynamic conditions and oxygen availability effects on microbial cultures in STBR:An overview, Biochem. Eng. J. 164 (2020) 107803
[2] L.W. Adams, M. Barigou, CFD analysis of caverns and pseudo-caverns developed during mixing of non-newtonian fluids, Chem. Eng. Res. Des. 85 (A5) (2007) 598-604
[3] R.S. Ghadge, A.W. Patwardhan, S.B. Sawant, J.B. Joshi, Effect of flow pattern on cellulase deactivation in stirred tank bioreactors, Chem. Eng. Sci. 60 (4) (2005) 1067-1083
[4] C. Selomulya, G. Bushell, R. Amal, T.D. Waite, Aggregate properties in relation to aggregation conditions under various applied shear environments, Int. J. Miner. Process. 73 (2-4) (2004) 295-307
[5] J. Ramirez-Munoz, G. Martinez-de-Jesus, A. Soria, A. Alonso, L.G. Torres, Assessment of the effective viscous dissipation for deagglomeration processes induced by a high shear impeller in a stirred tank, Adv. Powder Technol. 27 (5) (2016) 1885-1897
[6] A.E. DeJong, R.W. Hartel, Impact of shear on crystallization behavior of sorbitol, J. Food Eng. 263 (2019) 30-37
[7] W.W. Hu, C. Berdugo, J.J. Chalmers, The potential of hydrodynamic damage to animal cells of industrial relevance:current understanding, Cytotechnology 63 (5) (2011) 445-460
[8] Y. Chisti, Hydrodynamic damage to animal cells, Crit. Rev. Biotechnol. 21 (2) (2001) 67-110
[9] C.M. Mcfarlane, A.W. Nienow, Studies of high solidity ratio hydrofoil impellers for aerated bioreactors.1. Review, Biotechnol. Prog. 11 (6) (1995) 601-607
[10] J. Wu, L.J. Graham, N.N. Mehidi, Estimation of agitator flow shear rate, AIChE J. 52 (7) (2006) 2323-2332
[11] D.S. Dickey, J.B. Fasano, How geometry & viscosity influence mixing, Chem. Eng. 111 (2) (2004) 42-46
[12] A.B. Metzner, R.E. Otto, Agitation of non-Newtonian fluids, AIChE J. 3 (1) (1957) 3-10
[13] P.H. Calderbank, M.B. Moo-Young, The prediction of power consumption in the agitation of non-Newtonian fluids, Chem. Eng. Res. Des. 37 (1959) 26-33
[14] W. Kelly, B. Gigas, Using CFD to predict the behavior of power law fluids near axial-flow impellers operating in the transitional flow regime, Chem. Eng. Sci. 58 (10) (2003) 2141-2152
[15] K. Wichterle, M. Kadlec, L. Zak, P. Mitschka, Shear rates on turbine impeller blades, Chem. Eng. Commun. 26 (1-3) (1984) 25-32
[16] J.A. Sanchez Perez, E.M. Rodriguez Porcel, J.L. Casas Lopez, J.M. Fernandez Sevilla, Y. Chisti, Shear rate in stirred tank and bubble column bioreactors, Chem. Eng. J. 124 (2006) 1-5
[17] D.F. Del Pozo, A. Line, K.M. Van Geem, C. Le Men, I. Nopens, Hydrodynamic analysis of an axial impeller in a non-Newtonian fluid through particle image velocimetry, AIChE J. 66 (6) (2020) e16939
[18] J.K. Jiang, J. Wu, S. Poncin, H.Z. Li, Effect of hydrodynamic shear on biogas production and granule characteristics in a continuous stirred tank reactor, Process Biochem. 51 (3) (2016) 345-351
[19] Y.L. Zhang, Z.M. Gao, Z.P. Li, J.J. Derksen, Transitional flow in a Rushton turbine stirred tank, AIChE J. 63 (8) (2017) 3610-3623
[20] A. Story, Z. Jaworski, M.J. Simmons, E. Nowak, Comparative PIV and LDA studies of Newtonian and non-Newtonian flows in an agitated tank, Chem. Pap. 72 (3) (2018) 593-602
[21] J. Ramsay, M.J.H. Simmons, A. Ingram, E.H. Stitt, Mixing of Newtonian and viscoelastic fluids using "butterfly" impellers, Chem. Eng. Sci. 139 (2016) 125-141
[22] M.L. Collignon, A. Delafosse, M. Crine, D. Toye, Axial impeller selection for anchorage dependent animal cell culture in stirred bioreactors:Methodology based on the impeller comparison at just-suspended speed of rotation, Chem. Eng. Sci. 65 (22) (2010) 5929-5941
[23] J. Sossa-Echeverria, F. Taghipour, Computational simulation of mixing flow of shear thinning non-Newtonian fluids with various impellers in a stirred tank, Chem. Eng. Process. Process Intensif. 93 (2015) 66-78
[24] M. Taghavi, R. Zadghaffari, J. Moghaddas, Y. Moghaddas, Experimental and CFD investigation of power consumption in a dual Rushton turbine stirred tank, Chem. Eng. Res. Des. 89 (3a) (2011) 280-290
[25] N.N. Ma, Bioreactor scale-up strategies in large scale production of antibody, Prog. Pharm. Sci. 41 (2017) 645-652. (in Chinese)
[26] F. Garcia-Ochoa, E. Gomez, Bioreactor scale-up and oxygen transfer rate in microbial processes:An overview, Biotechnol. Adv. 27 (2) (2009) 153-176
[27] F. Garcia-Ochoa, S. Escobar, E. Gomez, Specific oxygen uptake rate as indicator of cell response of Rhodococcus erythropolis cultures to shear effects, Chem. Eng. Sci. 122 (2015) 491-499
[28] Y. Liu, Z.J. Wang, J.Y. Xia, C. Haringa, Y.P. Liu, J. Chu, Y.P. Zhuang, S.L. Zhang, Application of Euler-Lagrange CFD for quantitative evaluating the effect of shear force on Carthamus tinctorius L. cell in a stirred tank bioreactor, Biochem. Eng. J. 114 (2016) 212-220
[29] J.B. Sieck, T. Cordes, W.E. Budach, M.H. Rhiel, Z. Suemeghy, C. Leist, T.K. Villiger, M. Morbidelli, M. Soos, Development of a scale-down model of hydrodynamic stress to study the performance of an industrial CHO cell line under simulated production scale bioreactor conditions, J. Biotechnol. 164 (1) (2013) 41-49
[30] B.S. Borys, E.L. Roberts, A. Le, M.S. Kallos, Scale-up of embryonic stem cell aggregate stirred suspension bioreactor culture enabled by computational fluid dynamics modeling, Biochem. Eng. J. 133 (2018) 157-167
[31] A.R. Lara, E. Galindo, O.T. Ramirez, L.A. Palomares, Living with heterogeneities in bioreactors, Mol. Biotechnol. 34 (3) (2006) 355-381
[32] Y. Xu, B. Wu, P.C. Luo, Investigation on the flow characteristics of a novel multi-blade combined agitator by time-resolved particle image velocimetry and large eddy simulation, AIChE J. 66 (8) (2020) e16277
[33] A. Gabriele, A.W. Nienow, M.J.H. Simmons, Use of angle resolved PIV to estimate local specific energy dissipation rates for up- and down-pumping pitched blade agitators in a stirred tank, Chem. Eng. Sci. 64 (1) (2009) 126-143
[34] C. Li, X.N. Teng, H.D. Peng, X.P. Yi, Y.P. Zhuang, S.L. Zhang, J.Y. Xia, Novel scale-up strategy based on three-dimensional shear space for animal cell culture, Chem. Eng. Sci. 212 (2020) 115329
[35] Q. Tang, S.S.Ye, Y.D. Wang, Mixing time and flow characteristic in square pump-mix mixer under different scale-up criteria, CIESC Journal 67 (2016) 448-457. (in Chinese)
[36] C. Yang, T. Wang, Z.-S. Mao, J.C. Cheng, X.Y. Li, G.Z. Yu, A stirring impeller device for generating centripetal flow, China Pat., 102049208 (2009)
[37] T. Li, Z.T. Jia, Q.H. Zhang, C. Yang, Z.-S. Mao, Comparison of macro-mixing characteristics of a stirred tank with different impellers, CIESC Journal 70 (2019) 32-38 (in Chinese)
[38] Z.P. Chen, X.W. Zhang, X.H. Lin, Mixing and mixing equipment design and selection manual, Chemical Industry Press, Beijing, 2004
[39] Z.P. Chen, X.W. Zhang, X.H. Lin, Mixing and mixing equipment design and selection manual, Chemical Industry Press, Beijing, 2004
[40] N.A. Stathopoulos, J.D. Hellums, Shear stress effects on human embryonic kidney cells in Vitro, Biotechnol. Bioeng. 27 (7) (1985) 1021-1026
[41] D.A. Wolf, T.J. Goodwin, T.L. Prewett, G.F. Spaulding, Reduced shear stress:A major component in the ability of mammalian tissues to form three-dimensional assemblies in simulated microgravity, J. Cell. Biochem. 51 (1993) 301-311
[42] X. Yan, Z.Q. Zhang, C.Z. Gu, H.S. Hong, Cell culture of impeller suitable for animals and its numerical simulation, Mod. Chem. Ind. 10 (34) (2014) 162-166 (in Chinese)
[43] H. Wu, G.K. Patterson, Laser-Doppler measurements of turbulent-flow parameters in a stirred mixer, Chem. Eng. Sci. 44 (10) (1989) 2207-2221
[44] H.Z. Lu, C. Li, W.J. Tang, Z.J. Wang, J.Y. Xia, S.L. Zhang, Y.P. Zhuang, J. Chu, H. Noorman, Dependence of fungal characteristics on seed morphology and shear stress in bioreactors, Bioprocess Biosyst. Eng. 38 (5) (2015) 917-928

Effect of impeller type and scale-up on spatial distribution of shear rate in a stirred tank

Effect of impeller type and scale-up on spatial distribution of shear rate in a stirred tank

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