Efficient and selective extraction of sinomenine by deep eutectic solvents

doi:10.1016/j.cjche.2022.09.016

中国化学工程学报 ›› 2023, Vol. 57 ›› Issue (5): 109-117.DOI: 10.1016/j.cjche.2022.09.016

• Full Length Article • 上一篇下一篇

Efficient and selective extraction of sinomenine by deep eutectic solvents

Yunchang Fan¹, Chunyan Zhu¹, Sheli Zhang², Lei Zhang¹, Qiang Wang¹, Feng Wang¹

1. College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454003, China;
2. College of Science and Technology, Jiaozuo Teachers College, Jiaozuo 454000, China

收稿日期:2022-06-20 修回日期:2022-09-02 出版日期:2023-05-28 发布日期:2023-07-08
通讯作者: Yunchang Fan,E-mail:fanyunchang@hpu.edu.cn
基金资助:
This research was financially supported by the National Natural Science Foundation of China (21307028), Foundation of Henan province (202102310614), the Fundamental Research Funds for the Universities of Henan Province (NSFRF210428) and the Foundation of Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University (KJS2016).

Efficient and selective extraction of sinomenine by deep eutectic solvents

Yunchang Fan¹, Chunyan Zhu¹, Sheli Zhang², Lei Zhang¹, Qiang Wang¹, Feng Wang¹

1. College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454003, China;
2. College of Science and Technology, Jiaozuo Teachers College, Jiaozuo 454000, China

Received:2022-06-20 Revised:2022-09-02 Online:2023-05-28 Published:2023-07-08
Contact: Yunchang Fan,E-mail:fanyunchang@hpu.edu.cn
Supported by:
This research was financially supported by the National Natural Science Foundation of China (21307028), Foundation of Henan province (202102310614), the Fundamental Research Funds for the Universities of Henan Province (NSFRF210428) and the Foundation of Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University (KJS2016).

摘要/Abstract

摘要： Sinomenine is the main bio-active ingredient of Sinomenii Caulis and usually produced by solvent-extraction techniques. However, the extraction of sinomenine suffers from the lack of highly efficient and environmentally-benign solvents. In this work, deep eutectic solvents (DESs) based on fragrances were synthesized, hydrogen-bond donors (HBDs) and hydrogen-bond acceptors (HBAs) components of DESs were identified and their extraction ability for sinomenine was evaluated and the extraction conditions were optimized by single-factor and orthogonal design experiments. It was found that the hydrogen-bonding interaction between sinomenine and DESs was the main extraction driving force and there was no explicit relationship between the extraction ability and the hydrophobicity of the DESs. The DESs could be recycled and sinomenine could be recovered quantitatively via back-extraction. High-purity sinomenine ((95.0 ±2.3)%) could be produced. These findings suggest that DESs are highly-effective solvents for the isolation of sinomenine and exhibit great potential for the extraction of other bio-active compounds.

关键词: Sinomenine, Solvent extraction, Deep eutectic solvent (DES), Hydrogen-bonding interaction, Regeneration, Purification

Abstract: Sinomenine is the main bio-active ingredient of Sinomenii Caulis and usually produced by solvent-extraction techniques. However, the extraction of sinomenine suffers from the lack of highly efficient and environmentally-benign solvents. In this work, deep eutectic solvents (DESs) based on fragrances were synthesized, hydrogen-bond donors (HBDs) and hydrogen-bond acceptors (HBAs) components of DESs were identified and their extraction ability for sinomenine was evaluated and the extraction conditions were optimized by single-factor and orthogonal design experiments. It was found that the hydrogen-bonding interaction between sinomenine and DESs was the main extraction driving force and there was no explicit relationship between the extraction ability and the hydrophobicity of the DESs. The DESs could be recycled and sinomenine could be recovered quantitatively via back-extraction. High-purity sinomenine ((95.0 ±2.3)%) could be produced. These findings suggest that DESs are highly-effective solvents for the isolation of sinomenine and exhibit great potential for the extraction of other bio-active compounds.

Key words: Sinomenine, Solvent extraction, Deep eutectic solvent (DES), Hydrogen-bonding interaction, Regeneration, Purification

Yunchang Fan, Chunyan Zhu, Sheli Zhang, Lei Zhang, Qiang Wang, Feng Wang. Efficient and selective extraction of sinomenine by deep eutectic solvents[J]. 中国化学工程学报, 2023, 57(5): 109-117.

Yunchang Fan, Chunyan Zhu, Sheli Zhang, Lei Zhang, Qiang Wang, Feng Wang. Efficient and selective extraction of sinomenine by deep eutectic solvents[J]. Chinese Journal of Chemical Engineering, 2023, 57(5): 109-117.

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Efficient and selective extraction of sinomenine by deep eutectic solvents

Efficient and selective extraction of sinomenine by deep eutectic solvents

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