SCI和EI收录∣中国化工学会会刊

中国化学工程学报 ›› 2023, Vol. 57 ›› Issue (5): 109-117.DOI: 10.1016/j.cjche.2022.09.016

• Full Length Article • 上一篇    下一篇

Efficient and selective extraction of sinomenine by deep eutectic solvents

Yunchang Fan1, Chunyan Zhu1, Sheli Zhang2, Lei Zhang1, Qiang Wang1, Feng Wang1   

  1. 1. College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454003, China;
    2. College of Science and Technology, Jiaozuo Teachers College, Jiaozuo 454000, China
  • 收稿日期:2022-06-20 修回日期:2022-09-02 出版日期:2023-05-28 发布日期:2023-07-08
  • 通讯作者: Yunchang Fan,E-mail:fanyunchang@hpu.edu.cn
  • 基金资助:
    This research was financially supported by the National Natural Science Foundation of China (21307028), Foundation of Henan province (202102310614), the Fundamental Research Funds for the Universities of Henan Province (NSFRF210428) and the Foundation of Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University (KJS2016).

Efficient and selective extraction of sinomenine by deep eutectic solvents

Yunchang Fan1, Chunyan Zhu1, Sheli Zhang2, Lei Zhang1, Qiang Wang1, Feng Wang1   

  1. 1. College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454003, China;
    2. College of Science and Technology, Jiaozuo Teachers College, Jiaozuo 454000, China
  • Received:2022-06-20 Revised:2022-09-02 Online:2023-05-28 Published:2023-07-08
  • Contact: Yunchang Fan,E-mail:fanyunchang@hpu.edu.cn
  • Supported by:
    This research was financially supported by the National Natural Science Foundation of China (21307028), Foundation of Henan province (202102310614), the Fundamental Research Funds for the Universities of Henan Province (NSFRF210428) and the Foundation of Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University (KJS2016).

摘要: Sinomenine is the main bio-active ingredient of Sinomenii Caulis and usually produced by solvent-extraction techniques. However, the extraction of sinomenine suffers from the lack of highly efficient and environmentally-benign solvents. In this work, deep eutectic solvents (DESs) based on fragrances were synthesized, hydrogen-bond donors (HBDs) and hydrogen-bond acceptors (HBAs) components of DESs were identified and their extraction ability for sinomenine was evaluated and the extraction conditions were optimized by single-factor and orthogonal design experiments. It was found that the hydrogen-bonding interaction between sinomenine and DESs was the main extraction driving force and there was no explicit relationship between the extraction ability and the hydrophobicity of the DESs. The DESs could be recycled and sinomenine could be recovered quantitatively via back-extraction. High-purity sinomenine ((95.0 ±2.3)%) could be produced. These findings suggest that DESs are highly-effective solvents for the isolation of sinomenine and exhibit great potential for the extraction of other bio-active compounds.

关键词: Sinomenine, Solvent extraction, Deep eutectic solvent (DES), Hydrogen-bonding interaction, Regeneration, Purification

Abstract: Sinomenine is the main bio-active ingredient of Sinomenii Caulis and usually produced by solvent-extraction techniques. However, the extraction of sinomenine suffers from the lack of highly efficient and environmentally-benign solvents. In this work, deep eutectic solvents (DESs) based on fragrances were synthesized, hydrogen-bond donors (HBDs) and hydrogen-bond acceptors (HBAs) components of DESs were identified and their extraction ability for sinomenine was evaluated and the extraction conditions were optimized by single-factor and orthogonal design experiments. It was found that the hydrogen-bonding interaction between sinomenine and DESs was the main extraction driving force and there was no explicit relationship between the extraction ability and the hydrophobicity of the DESs. The DESs could be recycled and sinomenine could be recovered quantitatively via back-extraction. High-purity sinomenine ((95.0 ±2.3)%) could be produced. These findings suggest that DESs are highly-effective solvents for the isolation of sinomenine and exhibit great potential for the extraction of other bio-active compounds.

Key words: Sinomenine, Solvent extraction, Deep eutectic solvent (DES), Hydrogen-bonding interaction, Regeneration, Purification