Carotenoids Particle Formation by Supercritical Fluid Technologies

›› 2009, Vol. 17 ›› Issue (2): 344-349.

Carotenoids Particle Formation by Supercritical Fluid Technologies

全灿¹, Johan Carlfors², Charlotta Turner³

1. Division of Chemistry, National Institute of Metrology, Beijing 100013, China;
2. Department of Pharmaceutics, Faculty of Pharmacy, Uppsala University, Uppsala, SE75123, Sweden;
3. Department of Analytical Chemistry, Uppsala University, Uppsala, SE75124, Sweden

收稿日期:2008-04-14 修回日期:2009-02-17 出版日期:2009-04-28 发布日期:2009-04-28
通讯作者: Charlotta Turner,E-mail:charlotta.turner@kemi.uu.se
基金资助:
Supported partially by the China Ministry of Science and Technology for the China's Agenda 21 Strategic Research (MOST,2008IM021900);the General Administration of Quality Supervision Inspection and Quarantine of the People's Republic of China for the 4th Food Safety Research (AQSIQ 2008:ASPAQ0809)

Carotenoids Particle Formation by Supercritical Fluid Technologies

QUAN Can¹, Johan Carlfors², Charlotta Turner³

1. Division of Chemistry, National Institute of Metrology, Beijing 100013, China;
2. Department of Pharmaceutics, Faculty of Pharmacy, Uppsala University, Uppsala, SE75123, Sweden;
3. Department of Analytical Chemistry, Uppsala University, Uppsala, SE75124, Sweden

Received:2008-04-14 Revised:2009-02-17 Online:2009-04-28 Published:2009-04-28
Supported by:
Supported partially by the China Ministry of Science and Technology for the China's Agenda 21 Strategic Research (MOST,2008IM021900);the General Administration of Quality Supervision Inspection and Quarantine of the People's Republic of China for the 4th Food Safety Research (AQSIQ 2008:ASPAQ0809)

摘要/Abstract

摘要： Based on the solubility in supercritical CO₂,two strategies in which CO₂ plays different roles are used to make quercetine and astaxanthin particles by supercritical fluid technologies.The experimental results showed that micronized quercetine particles with mean particle size of 1.0-1.5 μm can be made via solution enhanced dispersion by supercritical fluids(SEDS) process,in which CO₂ worked as turbulent anti-solvent;while for astaxanthin,micronized particles with mean particle size of 0.3-0.8 μm were also made successfully by rapid expansion supercritical solution(RESS) process.

关键词: quercetine, astaxanthin, rapid expansion of supercritical solution, solution enhanced dispersion by supercritical fluids, particle formation

Abstract: Based on the solubility in supercritical CO₂,two strategies in which CO₂ plays different roles are used to make quercetine and astaxanthin particles by supercritical fluid technologies.The experimental results showed that micronized quercetine particles with mean particle size of 1.0-1.5 μm can be made via solution enhanced dispersion by supercritical fluids(SEDS) process,in which CO₂ worked as turbulent anti-solvent;while for astaxanthin,micronized particles with mean particle size of 0.3-0.8 μm were also made successfully by rapid expansion supercritical solution(RESS) process.

Key words: quercetine, astaxanthin, rapid expansion of supercritical solution, solution enhanced dispersion by supercritical fluids, particle formation

全灿, Johan Carlfors, Charlotta Turner. Carotenoids Particle Formation by Supercritical Fluid Technologies[J]. , 2009, 17(2): 344-349.

QUAN Can, Johan Carlfors, Charlotta Turner. Carotenoids Particle Formation by Supercritical Fluid Technologies[J]. , 2009, 17(2): 344-349.

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Carotenoids Particle Formation by Supercritical Fluid Technologies

Carotenoids Particle Formation by Supercritical Fluid Technologies

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