SCI和EI收录∣中国化工学会会刊

Chinese Journal of Chemical Engineering ›› 2021, Vol. 38 ›› Issue (10): 53-62.DOI: 10.1016/j.cjche.2021.05.025

• Fluid Dynamics and Transport Phenomena • Previous Articles     Next Articles

Effects of piperacillin synthesis on the interfacial tensions and droplet sizes

Yu Xie1, Guoming Huang2, Weiguo Hu2, Yujun Wang1   

  1. 1. The State Key Laboratory of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China;
    2. North China Pharmaceutical Group Co., Ltd., Shijiazhuang 052165, China
  • Received:2020-12-14 Revised:2021-03-24 Online:2021-12-02 Published:2021-10-28
  • Contact: Yujun Wang
  • Supported by:
    This work was financially supported by the National Key Research and Development Program of China (2019YFA0905100), the National Natural Science Foundation of China (21878169 and 21991102), and Tsinghua University Initiative Scientific Research Program (2018Z05JZY010).

Effects of piperacillin synthesis on the interfacial tensions and droplet sizes

Yu Xie1, Guoming Huang2, Weiguo Hu2, Yujun Wang1   

  1. 1. The State Key Laboratory of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China;
    2. North China Pharmaceutical Group Co., Ltd., Shijiazhuang 052165, China
  • 通讯作者: Yujun Wang
  • 基金资助:
    This work was financially supported by the National Key Research and Development Program of China (2019YFA0905100), the National Natural Science Foundation of China (21878169 and 21991102), and Tsinghua University Initiative Scientific Research Program (2018Z05JZY010).

Abstract: Piperacillin is a polar organic substance, and can reduce the interfacial tension of oil and water when dissolved in water. In this study, changes in dichloromethane-water interfacial tensions and microdroplet sizes during piperacillin synthesis from an aqueous solution of ampicillin and dichloromethane solution of 4-ethyl-2,3-dioxo-1-piperazine carbonyl chloride (EDPC) were observed using a pendent drop technique and a coaxial ring tube system with embedded high-speed camera, respectively. It was found that the rapid N-acylation reaction caused the piperacillin at the interface to synthesize rapidly and diffuse out slowly, resulting in the interfacial tension decreased from 19.5 mN·m-1 to 7.2 mN·m-1 rapidly and then increased slowly as the concentrations of ampicillin and EDPC were 0.05 mol·L-1 and 0.1 mol·L-1. Meanwhile, the increase in the concentration of EDPC increased the peak concentration of piperacillin at the interface, and the addition of ethyl acetate to the ampicillin solution promoted mass transfer and reduced the aggregation of piperacillin effectively. During synthesis, the interfacial tension decreased, leading to a change in droplet sizes in the micro-reaction system. The two-phase reaction was carried out in a coaxial ring tube, with ampicillin and EDPC solutions as continuous and dispersed phases, respectively. The reaction reduced the dripping flow area, and the addition of ethyl acetate to the ampicillin solution slightly affected the division of the flow pattern. Under the same flow conditions, the droplet sizes of the reaction group were smaller than those of the no reaction group. The experimental results demonstrated that the increase of the continuous phase, decrease in the dispersed phase flow rate, or increase in EDPC concentration making droplet sizes smaller, and the addition of ethyl acetate slightly affected droplet sizes. These findings are important for the design and optimization of piperacillin synthesis reactors.

Key words: Pendant drop, Interfacial tension, Microchannel, Droplet size, Piperacillin synthesis, Mass transfer

摘要: Piperacillin is a polar organic substance, and can reduce the interfacial tension of oil and water when dissolved in water. In this study, changes in dichloromethane-water interfacial tensions and microdroplet sizes during piperacillin synthesis from an aqueous solution of ampicillin and dichloromethane solution of 4-ethyl-2,3-dioxo-1-piperazine carbonyl chloride (EDPC) were observed using a pendent drop technique and a coaxial ring tube system with embedded high-speed camera, respectively. It was found that the rapid N-acylation reaction caused the piperacillin at the interface to synthesize rapidly and diffuse out slowly, resulting in the interfacial tension decreased from 19.5 mN·m-1 to 7.2 mN·m-1 rapidly and then increased slowly as the concentrations of ampicillin and EDPC were 0.05 mol·L-1 and 0.1 mol·L-1. Meanwhile, the increase in the concentration of EDPC increased the peak concentration of piperacillin at the interface, and the addition of ethyl acetate to the ampicillin solution promoted mass transfer and reduced the aggregation of piperacillin effectively. During synthesis, the interfacial tension decreased, leading to a change in droplet sizes in the micro-reaction system. The two-phase reaction was carried out in a coaxial ring tube, with ampicillin and EDPC solutions as continuous and dispersed phases, respectively. The reaction reduced the dripping flow area, and the addition of ethyl acetate to the ampicillin solution slightly affected the division of the flow pattern. Under the same flow conditions, the droplet sizes of the reaction group were smaller than those of the no reaction group. The experimental results demonstrated that the increase of the continuous phase, decrease in the dispersed phase flow rate, or increase in EDPC concentration making droplet sizes smaller, and the addition of ethyl acetate slightly affected droplet sizes. These findings are important for the design and optimization of piperacillin synthesis reactors.

关键词: Pendant drop, Interfacial tension, Microchannel, Droplet size, Piperacillin synthesis, Mass transfer