SCI和EI收录∣中国化工学会会刊

Chinese Journal of Chemical Engineering ›› 2022, Vol. 49 ›› Issue (9): 34-45.DOI: 10.1016/j.cjche.2022.06.006

• Special Column: Membranes for Life Science • Previous Articles     Next Articles

Smart membranes for biomedical applications

Lin-Bing Zou1, Jue-Ying Gong1, Xiao-Jie Ju1,2, Zhuang Liu1,2, Wei Wang1,2, Rui Xie1,2, Liang-Yin Chu1,2   

  1. 1. School of Chemical Engineering, Sichuan University, Chengdu 610065, China;
    2. State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
  • Received:2021-11-28 Revised:2022-06-03 Online:2022-10-19
  • Contact: Xiao-Jie Ju,E-mail:juxiaojie@scu.edu.cn
  • Supported by:
    The authors gratefully acknowledge support from the National Natural Science Foundation of China (21991101, 22078202).

Smart membranes for biomedical applications

Lin-Bing Zou1, Jue-Ying Gong1, Xiao-Jie Ju1,2, Zhuang Liu1,2, Wei Wang1,2, Rui Xie1,2, Liang-Yin Chu1,2   

  1. 1. School of Chemical Engineering, Sichuan University, Chengdu 610065, China;
    2. State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
  • 通讯作者: Xiao-Jie Ju,E-mail:juxiaojie@scu.edu.cn
  • 基金资助:
    The authors gratefully acknowledge support from the National Natural Science Foundation of China (21991101, 22078202).

Abstract: Smart membranes with tunable permeability and selectivity have drawn widespread attention because of their unique biomimetic characteristics. Constructed by incorporating various stimuli-responsive materials into membrane substrates, smart membranes could self-adjust their physical/chemical properties (such as pore size and surface properties) in response to environmental signals such as temperature, pH, light, magnetic field, electric field, redox and specific ions/molecules. Such smart membranes show great prospects in biomedical applications ranging from controlled drug release to bioseparation and tissue engineering. In this review, three controlled release models realized by different designed smart membranes are emphatically introduced, and then smart membranes for biological separation and controlled cell culture are introduced and discussed respectively. At last, the existing challenges of smart membranes for biomedical applications are briefly summarized, and future research topics are suggested.

Key words: Membranes, Polymers, Smart materials, Controlled release, Bioseparation, Cell culture

摘要: Smart membranes with tunable permeability and selectivity have drawn widespread attention because of their unique biomimetic characteristics. Constructed by incorporating various stimuli-responsive materials into membrane substrates, smart membranes could self-adjust their physical/chemical properties (such as pore size and surface properties) in response to environmental signals such as temperature, pH, light, magnetic field, electric field, redox and specific ions/molecules. Such smart membranes show great prospects in biomedical applications ranging from controlled drug release to bioseparation and tissue engineering. In this review, three controlled release models realized by different designed smart membranes are emphatically introduced, and then smart membranes for biological separation and controlled cell culture are introduced and discussed respectively. At last, the existing challenges of smart membranes for biomedical applications are briefly summarized, and future research topics are suggested.

关键词: Membranes, Polymers, Smart materials, Controlled release, Bioseparation, Cell culture