SCI和EI收录∣中国化工学会会刊

›› 2014, Vol. 22 ›› Issue (9): 1005-1008.DOI: 10.1016/j.cjche.2014.06.024

• 催化、动力学与反应工程 • 上一篇    下一篇

Hydrolysis Kinetics of 2-Pyridinecarboxamide, 3-Pyridinecarboxamide and 4-Pyridinecarboxamide in High-Temperature Water

Jie Fu1, Haoming Ren1, Ju Zhu2, Xiuyang Lu1   

  1. 1 Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China;
    2 School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China
  • 收稿日期:2012-11-30 修回日期:2013-04-01 出版日期:2014-09-28 发布日期:2014-11-04
  • 通讯作者: Xiuyang Lu
  • 基金资助:
    Supported by the National Natural Science Foundation of China (21176218), and Zhejiang Key Innovation Team of Green Pharmaceutical Technology (2010R50043).

Hydrolysis Kinetics of 2-Pyridinecarboxamide, 3-Pyridinecarboxamide and 4-Pyridinecarboxamide in High-Temperature Water

Jie Fu1, Haoming Ren1, Ju Zhu2, Xiuyang Lu1   

  1. 1 Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China;
    2 School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China
  • Received:2012-11-30 Revised:2013-04-01 Online:2014-09-28 Published:2014-11-04
  • Supported by:
    Supported by the National Natural Science Foundation of China (21176218), and Zhejiang Key Innovation Team of Green Pharmaceutical Technology (2010R50043).

摘要: A kinetic study is reported here on hydrolysis of three pyridinecarboxamides in high-temperature water in the temperature range of 190-250℃ at 8 MPa. 2-Pyridinecarboxamide, 3-pyridinecarboxamide and 4-pyridinecarboxamide hydrolyze to corresponding picolinic acids. 2-Picolinic acid is further decarboxylated to pyridine. Experiments at different temperatures show that the first-order rate constants display an Arrhenius behavior with activation energies of (110.9 ± 2.3), (70.4 ± 2.1) and (61.4 ± 1.8) kJ·mol-1 for 2-pyridinecarboxamide, 3-pyridinecarboxamide and 4-pyridinecarboxamide, respectively. These kinetic parameters for pyridinecarboxamide hydrolysis are more reliable and accurate than those from the consecutive hydrolysis of cyanopyridines.

关键词: High-temperature water, Hydrolysis, Pyridinecarboxamide, Kinetics, Activation energy

Abstract: A kinetic study is reported here on hydrolysis of three pyridinecarboxamides in high-temperature water in the temperature range of 190-250℃ at 8 MPa. 2-Pyridinecarboxamide, 3-pyridinecarboxamide and 4-pyridinecarboxamide hydrolyze to corresponding picolinic acids. 2-Picolinic acid is further decarboxylated to pyridine. Experiments at different temperatures show that the first-order rate constants display an Arrhenius behavior with activation energies of (110.9 ± 2.3), (70.4 ± 2.1) and (61.4 ± 1.8) kJ·mol-1 for 2-pyridinecarboxamide, 3-pyridinecarboxamide and 4-pyridinecarboxamide, respectively. These kinetic parameters for pyridinecarboxamide hydrolysis are more reliable and accurate than those from the consecutive hydrolysis of cyanopyridines.

Key words: High-temperature water, Hydrolysis, Pyridinecarboxamide, Kinetics, Activation energy