Thermodynamic properties of metamizol monohydrate in pure and binary solvents at temperatures from (283.15 to 313.15) K

doi:10.1016/j.cjche.2017.03.026

›› 2017, Vol. 25 ›› Issue (10): 1481-1491.DOI: 10.1016/j.cjche.2017.03.026

• Chemical Engineering Thermodynamics • 上一篇下一篇

Thermodynamic properties of metamizol monohydrate in pure and binary solvents at temperatures from (283.15 to 313.15) K

Mingxia Guo¹, Qiuxiang Yin^1,2, Chang Wang¹, Yaohui Huang¹, Yang Li¹, Zaixiang Zhang¹, Xia Zhang¹, Zhao Wang^1,2, Meijing Zhang^1,2, Ling Zhou¹

1 School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China;
2 The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Tianjin University, Tianjin 300072, China

收稿日期:2016-11-19 修回日期:2017-03-17 出版日期:2017-10-28 发布日期:2017-03-25
通讯作者: Ling Zhou,E-mail address:zhouling@tju.edu.cn
基金资助:
Supported by National Natural Science Foundation of China (21206109) and China Ministry of Science and Major National Scientific Instrument Development Project (21527812).

Thermodynamic properties of metamizol monohydrate in pure and binary solvents at temperatures from (283.15 to 313.15) K

Mingxia Guo¹, Qiuxiang Yin^1,2, Chang Wang¹, Yaohui Huang¹, Yang Li¹, Zaixiang Zhang¹, Xia Zhang¹, Zhao Wang^1,2, Meijing Zhang^1,2, Ling Zhou¹

1 School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China;
2 The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Tianjin University, Tianjin 300072, China

Received:2016-11-19 Revised:2017-03-17 Online:2017-10-28 Published:2017-03-25
Supported by:
Supported by National Natural Science Foundation of China (21206109) and China Ministry of Science and Major National Scientific Instrument Development Project (21527812).

摘要/Abstract

摘要： The thermodynamic properties of metamizol monohydrate in pure solvents (methanol, ethanol, n-propanol and isopropanol) and two binary mixed solvent systems including (methanol + ethanol) and (methanol + isopropanol) were measured from 283.15 K to 313.15 K by gravimetric method under atmospheric pressure thought as 0.1 MPa. The modified Apelblat equation, the CNIBS/R-K equation, the Hybrid model and the NRTL model were used to correlate the solubility of metamizol monohydrate, respectively. The results show that the solubility of metamizol monohydrate in all the tested solvents increases with the rising temperature which means that it has temperature dependence. What's more, the effects of solvent components of the binary solvent mixtures on solubility were discussed, it illustrates that the increasing of the molar fraction of methanol gives the system a greater dissolving power. Furthermore, according to the NRTL model, the enthalpy, the Gibbs energy and the entropy of the mixing process were also obtained and discussed.

关键词: Metamizol monohydrate, Solubility, Thermodynamic properties, Correlation

Abstract: The thermodynamic properties of metamizol monohydrate in pure solvents (methanol, ethanol, n-propanol and isopropanol) and two binary mixed solvent systems including (methanol + ethanol) and (methanol + isopropanol) were measured from 283.15 K to 313.15 K by gravimetric method under atmospheric pressure thought as 0.1 MPa. The modified Apelblat equation, the CNIBS/R-K equation, the Hybrid model and the NRTL model were used to correlate the solubility of metamizol monohydrate, respectively. The results show that the solubility of metamizol monohydrate in all the tested solvents increases with the rising temperature which means that it has temperature dependence. What's more, the effects of solvent components of the binary solvent mixtures on solubility were discussed, it illustrates that the increasing of the molar fraction of methanol gives the system a greater dissolving power. Furthermore, according to the NRTL model, the enthalpy, the Gibbs energy and the entropy of the mixing process were also obtained and discussed.

Key words: Metamizol monohydrate, Solubility, Thermodynamic properties, Correlation

Mingxia Guo, Qiuxiang Yin, Chang Wang, Yaohui Huang, Yang Li, Zaixiang Zhang, Xia Zhang, Zhao Wang, Meijing Zhang, Ling Zhou. Thermodynamic properties of metamizol monohydrate in pure and binary solvents at temperatures from (283.15 to 313.15) K[J]. , 2017, 25(10): 1481-1491.

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Thermodynamic properties of metamizol monohydrate in pure and binary solvents at temperatures from (283.15 to 313.15) K

Thermodynamic properties of metamizol monohydrate in pure and binary solvents at temperatures from (283.15 to 313.15) K

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