SCI和EI收录∣中国化工学会会刊

Chinese Journal of Chemical Engineering ›› 2018, Vol. 26 ›› Issue (7): 1458-1467.DOI: 10.1016/j.cjche.2018.01.012

• Separation Science and Engineering • 上一篇    下一篇

Insight into the degradation mechanism of cefixime under crystallization condition

Lingyu Wang, Xiaona Li, Yumin Liu, Dandan Han, Shiyuan Liu, Teng Zhang, Bo Yu, Junbo Gong   

  1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
  • 收稿日期:2017-10-25 修回日期:2017-12-30 出版日期:2018-07-28 发布日期:2018-08-16
  • 通讯作者: Junbo Gong,E-mail address:junbo_gong@tju.edu.cn
  • 基金资助:

    Supported by the National Natural Science Foundation of China (81361140344 and 21376164), National High Technology Reseach and Development Program of China (863 Program, 2015AA021002) and Major National Scientific Instrument Development Project (21527812).

Insight into the degradation mechanism of cefixime under crystallization condition

Lingyu Wang, Xiaona Li, Yumin Liu, Dandan Han, Shiyuan Liu, Teng Zhang, Bo Yu, Junbo Gong   

  1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
  • Received:2017-10-25 Revised:2017-12-30 Online:2018-07-28 Published:2018-08-16
  • Contact: Junbo Gong,E-mail address:junbo_gong@tju.edu.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China (81361140344 and 21376164), National High Technology Reseach and Development Program of China (863 Program, 2015AA021002) and Major National Scientific Instrument Development Project (21527812).

摘要: The chemical stability of cefixime was determined by high-performance liquid chromatography (HPLC) under different conditions, including factors such as pH, solvents, initial concentration, temperature and additives. The degradation process follows the first-order kinetics. A pH-rate profile exhibits the U-shape and shows the maximum stability of cefixime at pH=6. The stability in different pure solvents is ranked as acetone N ethanol N methanol N water, while the degradation rate of cefixime exists a maximum at the ratio of 0.6 in water + methanol mixtures. In addition, the degradation rate increases with the temperature increasing and the activation energy of degradation was found to be 27.078 kJ·mol-1 in acetone + water mixed solvents. The addition of different additives was proven to either inhibit or accelerate the degradation. The degradation products were analyzed using HPLC, LC-MS and infrared spectroscopy, and the possible degradation pathways in acid as well as alkaline environment were proposed to help us understand the degradation behavior of cefixime.

关键词: Chemical stability, Degradation kinetics, Degradation Mechanism, Cefixime, Additives

Abstract: The chemical stability of cefixime was determined by high-performance liquid chromatography (HPLC) under different conditions, including factors such as pH, solvents, initial concentration, temperature and additives. The degradation process follows the first-order kinetics. A pH-rate profile exhibits the U-shape and shows the maximum stability of cefixime at pH=6. The stability in different pure solvents is ranked as acetone N ethanol N methanol N water, while the degradation rate of cefixime exists a maximum at the ratio of 0.6 in water + methanol mixtures. In addition, the degradation rate increases with the temperature increasing and the activation energy of degradation was found to be 27.078 kJ·mol-1 in acetone + water mixed solvents. The addition of different additives was proven to either inhibit or accelerate the degradation. The degradation products were analyzed using HPLC, LC-MS and infrared spectroscopy, and the possible degradation pathways in acid as well as alkaline environment were proposed to help us understand the degradation behavior of cefixime.

Key words: Chemical stability, Degradation kinetics, Degradation Mechanism, Cefixime, Additives