Fatty acid hydratase for value-added biotransformation: A review

doi:10.1016/j.cjche.2020.02.008

中国化学工程学报 ›› 2020, Vol. 28 ›› Issue (8): 2051-2063.DOI: 10.1016/j.cjche.2020.02.008

Fatty acid hydratase for value-added biotransformation: A review

Yan Zhang¹, Bekir Engin Eser¹, Peter Kristensen², Zheng Guo¹

1 Department of Engineering, Faculty of Science and Technology, Aarhus University, Gustav wieds vej 10, 8000 Aarhus, Denmark;
2 Faculty of Engineering and Science, Department of Chemistry and Bioscience, Aalborg University, 9220 Aalborg, Denmark

收稿日期:2020-01-02 修回日期:2020-01-27 出版日期:2020-08-28 发布日期:2020-09-19
通讯作者: Zheng Guo
基金资助:
Financial Supports from Novo Nordisk Foundation(-NNF16OC0021740) and Aarhus Universitets Forskningsfond, AUFFNOVA(AUFF-E-2015-FLS-9-12) are gratefully acknowledged.

Fatty acid hydratase for value-added biotransformation: A review

Yan Zhang¹, Bekir Engin Eser¹, Peter Kristensen², Zheng Guo¹

1 Department of Engineering, Faculty of Science and Technology, Aarhus University, Gustav wieds vej 10, 8000 Aarhus, Denmark;
2 Faculty of Engineering and Science, Department of Chemistry and Bioscience, Aalborg University, 9220 Aalborg, Denmark

Received:2020-01-02 Revised:2020-01-27 Online:2020-08-28 Published:2020-09-19
Contact: Zheng Guo
Supported by:
Financial Supports from Novo Nordisk Foundation(-NNF16OC0021740) and Aarhus Universitets Forskningsfond, AUFFNOVA(AUFF-E-2015-FLS-9-12) are gratefully acknowledged.

摘要/Abstract

摘要： The synthesis of hydroxy fatty acids (HFAs) from renewable oil feedstock by addition of water onto C=C bonds has attracted great attention in recent years. Given that selective asymmetric hydration of non-activated C=C bonds has been proven difficult to achieve with chemical catalysts, enzymatic catalysis by fatty acid hydratases (FAHs) presents an attractive alternative approach to produce value-added HFAs with high regio-, enantioand stereospecificity, as well as excellent atom economy. Even though FAHs have just been investigated as a potential biocatalyst for a decade, remarkable information about FAHs in different aspects is available; however, a comprehensive review has not been archived. Herein, we summarize the research progresses on biochemical characterization, structural and mechanistic determination, enzyme engineering, as well as biotechnological application of FAHs. The current challenges and opportunities for an efficient utilization of FAHs in organic synthesis and industrial applications are critically discussed.

关键词: Hydroxy fatty acids, Fatty acid hydratases, Enzyme characterization, Catalytic mechanism, Enzyme engineering, Biotransformation

Abstract: The synthesis of hydroxy fatty acids (HFAs) from renewable oil feedstock by addition of water onto C=C bonds has attracted great attention in recent years. Given that selective asymmetric hydration of non-activated C=C bonds has been proven difficult to achieve with chemical catalysts, enzymatic catalysis by fatty acid hydratases (FAHs) presents an attractive alternative approach to produce value-added HFAs with high regio-, enantioand stereospecificity, as well as excellent atom economy. Even though FAHs have just been investigated as a potential biocatalyst for a decade, remarkable information about FAHs in different aspects is available; however, a comprehensive review has not been archived. Herein, we summarize the research progresses on biochemical characterization, structural and mechanistic determination, enzyme engineering, as well as biotechnological application of FAHs. The current challenges and opportunities for an efficient utilization of FAHs in organic synthesis and industrial applications are critically discussed.

Key words: Hydroxy fatty acids, Fatty acid hydratases, Enzyme characterization, Catalytic mechanism, Enzyme engineering, Biotransformation

Yan Zhang, Bekir Engin Eser, Peter Kristensen, Zheng Guo. Fatty acid hydratase for value-added biotransformation: A review[J]. 中国化学工程学报, 2020, 28(8): 2051-2063.

Yan Zhang, Bekir Engin Eser, Peter Kristensen, Zheng Guo. Fatty acid hydratase for value-added biotransformation: A review[J]. Chinese Journal of Chemical Engineering, 2020, 28(8): 2051-2063.

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Fatty acid hydratase for value-added biotransformation: A review

Fatty acid hydratase for value-added biotransformation: A review

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