The potential of ionic liquids in biopharmaceutical engineering

doi:10.1016/j.cjche.2020.11.015

摘要/Abstract

摘要： Biopharmaceuticals, such as proteins, peptides, nucleic acids and vaccines, bring about great hopes for the prevention and treatment of various diseases, but the industrialization of these products still faces challenges such as structural instability, inefficient bioactivity and low bioavailability. Ionic liquids (ILs), the marvelous solvent media with inimitable and tunable properties, may provide alternative solutions to overcome the above problems of biopharmaceutical industry. Progress has gradually been made through studies by combination of ILs with biomacromolecules. The applications involved the stabilization, protection, and delivery of biopharmaceuticals. Recent trends are being forwarded to using ILs in vaccines and nucleic acid drugs. However, challenges remain on the toxicity and safety issues. Besides, the cost of adding ILs to the benefits of biopharmaceuticals need to be considered.

关键词: Ionic liquids, Biopharmaceutical engineering, Biomacromolecules, Stabilization, Vaccine, Delivery

Abstract: Biopharmaceuticals, such as proteins, peptides, nucleic acids and vaccines, bring about great hopes for the prevention and treatment of various diseases, but the industrialization of these products still faces challenges such as structural instability, inefficient bioactivity and low bioavailability. Ionic liquids (ILs), the marvelous solvent media with inimitable and tunable properties, may provide alternative solutions to overcome the above problems of biopharmaceutical industry. Progress has gradually been made through studies by combination of ILs with biomacromolecules. The applications involved the stabilization, protection, and delivery of biopharmaceuticals. Recent trends are being forwarded to using ILs in vaccines and nucleic acid drugs. However, challenges remain on the toxicity and safety issues. Besides, the cost of adding ILs to the benefits of biopharmaceuticals need to be considered.

Key words: Ionic liquids, Biopharmaceutical engineering, Biomacromolecules, Stabilization, Vaccine, Delivery

Xuan Lin, Zhiguo Su, Yanli Yang, Songping Zhang. The potential of ionic liquids in biopharmaceutical engineering[J]. 中国化学工程学报, 2021, 29(2): 236-243.

Xuan Lin, Zhiguo Su, Yanli Yang, Songping Zhang. The potential of ionic liquids in biopharmaceutical engineering[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 236-243.

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