SCI和EI收录∣中国化工学会会刊

中国化学工程学报 ›› 2021, Vol. 29 ›› Issue (2): 236-243.DOI: 10.1016/j.cjche.2020.11.015

• Biomedical Engineering • 上一篇    下一篇

The potential of ionic liquids in biopharmaceutical engineering

Xuan Lin, Zhiguo Su, Yanli Yang, Songping Zhang   

  1. State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
  • 收稿日期:2020-10-15 修回日期:2020-11-25 出版日期:2021-02-28 发布日期:2021-05-15
  • 通讯作者: Yanli Yang, Songping Zhang
  • 基金资助:
    The authors are thankful for the financial support from the National Natural Science Foundation of China (Nos. 21808226, 31970872, and 21821005).

The potential of ionic liquids in biopharmaceutical engineering

Xuan Lin, Zhiguo Su, Yanli Yang, Songping Zhang   

  1. State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
  • Received:2020-10-15 Revised:2020-11-25 Online:2021-02-28 Published:2021-05-15
  • Contact: Yanli Yang, Songping Zhang
  • Supported by:
    The authors are thankful for the financial support from the National Natural Science Foundation of China (Nos. 21808226, 31970872, and 21821005).

摘要: Biopharmaceuticals, such as proteins, peptides, nucleic acids and vaccines, bring about great hopes for the prevention and treatment of various diseases, but the industrialization of these products still faces challenges such as structural instability, inefficient bioactivity and low bioavailability. Ionic liquids (ILs), the marvelous solvent media with inimitable and tunable properties, may provide alternative solutions to overcome the above problems of biopharmaceutical industry. Progress has gradually been made through studies by combination of ILs with biomacromolecules. The applications involved the stabilization, protection, and delivery of biopharmaceuticals. Recent trends are being forwarded to using ILs in vaccines and nucleic acid drugs. However, challenges remain on the toxicity and safety issues. Besides, the cost of adding ILs to the benefits of biopharmaceuticals need to be considered.

关键词: Ionic liquids, Biopharmaceutical engineering, Biomacromolecules, Stabilization, Vaccine, Delivery

Abstract: Biopharmaceuticals, such as proteins, peptides, nucleic acids and vaccines, bring about great hopes for the prevention and treatment of various diseases, but the industrialization of these products still faces challenges such as structural instability, inefficient bioactivity and low bioavailability. Ionic liquids (ILs), the marvelous solvent media with inimitable and tunable properties, may provide alternative solutions to overcome the above problems of biopharmaceutical industry. Progress has gradually been made through studies by combination of ILs with biomacromolecules. The applications involved the stabilization, protection, and delivery of biopharmaceuticals. Recent trends are being forwarded to using ILs in vaccines and nucleic acid drugs. However, challenges remain on the toxicity and safety issues. Besides, the cost of adding ILs to the benefits of biopharmaceuticals need to be considered.

Key words: Ionic liquids, Biopharmaceutical engineering, Biomacromolecules, Stabilization, Vaccine, Delivery