Liquid–solid mass transfer in micropacked bed reactors with immiscible liquid–liquid two-phase flow

doi:10.1016/j.cjche.2025.04.006

中国化学工程学报 ›› 2025, Vol. 85 ›› Issue (9): 1-6.DOI: 10.1016/j.cjche.2025.04.006

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Liquid–solid mass transfer in micropacked bed reactors with immiscible liquid–liquid two-phase flow

Yanfu Chen^1,2, Chu Zhou^1,2, Dang Cheng^1,2, Fener Chen^1,2

1. Engineering Center for Catalysis and Synthesis of Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China;
2. Shanghai Engineering & Technology Research Center for Industrial Asymmetric Catalysis of Chiral Drugs, Shanghai 200433, China

收稿日期:2025-01-22 修回日期:2025-04-10 接受日期:2025-04-13 出版日期:2025-09-28 发布日期:2025-05-03
通讯作者: Dang Cheng,E-mail:dcheng@fudan.edu.cn;Fener Chen,E-mail:rfchen@fudan.edu.cn

Liquid–solid mass transfer in micropacked bed reactors with immiscible liquid–liquid two-phase flow

Yanfu Chen^1,2, Chu Zhou^1,2, Dang Cheng^1,2, Fener Chen^1,2

1. Engineering Center for Catalysis and Synthesis of Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China;
2. Shanghai Engineering & Technology Research Center for Industrial Asymmetric Catalysis of Chiral Drugs, Shanghai 200433, China

Received:2025-01-22 Revised:2025-04-10 Accepted:2025-04-13 Online:2025-09-28 Published:2025-05-03
Contact: Dang Cheng,E-mail:dcheng@fudan.edu.cn;Fener Chen,E-mail:rfchen@fudan.edu.cn

摘要/Abstract

摘要： Herein, the liquid-solid mass transfer characteristics in micropacked bed reactors (μPBRs) operated with immiscible liquid-liquid two-phase flow is experimentally investigated. It is found that the overall volumetric liquid-solid mass transfer coefficient (k_sa) increases with the total flow rate and the channel-to-particle diameter ratio, while decreases with the organic-to-aqueous phase flow rate ratio. A satisfactory correlation model for calculating k_sa of the liquid-liquid μPBRs is developed. The new knowledge obtained would be useful in guiding the design and optimization of the liquid-liquid μPBRs.

关键词: Microreactor, Packed bed, Spherical particle, Liquid-liquid-solid system, Mass transfer, Liquid-liquid-solid transfer model

Abstract: Herein, the liquid-solid mass transfer characteristics in micropacked bed reactors (μPBRs) operated with immiscible liquid-liquid two-phase flow is experimentally investigated. It is found that the overall volumetric liquid-solid mass transfer coefficient (k_sa) increases with the total flow rate and the channel-to-particle diameter ratio, while decreases with the organic-to-aqueous phase flow rate ratio. A satisfactory correlation model for calculating k_sa of the liquid-liquid μPBRs is developed. The new knowledge obtained would be useful in guiding the design and optimization of the liquid-liquid μPBRs.

Key words: Microreactor, Packed bed, Spherical particle, Liquid-liquid-solid system, Mass transfer, Liquid-liquid-solid transfer model

Yanfu Chen, Chu Zhou, Dang Cheng, Fener Chen. Liquid–solid mass transfer in micropacked bed reactors with immiscible liquid–liquid two-phase flow[J]. 中国化学工程学报, 2025, 85(9): 1-6.

Yanfu Chen, Chu Zhou, Dang Cheng, Fener Chen. Liquid–solid mass transfer in micropacked bed reactors with immiscible liquid–liquid two-phase flow[J]. Chinese Journal of Chemical Engineering, 2025, 85(9): 1-6.

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Liquid–solid mass transfer in micropacked bed reactors with immiscible liquid–liquid two-phase flow

Liquid–solid mass transfer in micropacked bed reactors with immiscible liquid–liquid two-phase flow

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