Study on Synthesis and Chloramphenicol Release of Poly(2-hydroxyethylmethacrylate-co-acrylamide)Hydrogels

›› 2008, Vol. 16 ›› Issue (4): 640-645.

Study on Synthesis and Chloramphenicol Release of Poly(2-hydroxyethylmethacrylate-co-acrylamide)Hydrogels

黎新明, 崔英德

School of Chemistry, Chemical Engineering, Zhongkai University of Agriculture, Engineering, Guangzhou 510225, China

收稿日期:2007-10-23 修回日期:2008-03-08 出版日期:2008-08-28 发布日期:2008-08-28
通讯作者: LI Xinming, E-mail: lixinming@sina.com
基金资助:
the Natural Science Foundation of Guangdong Province(5300978);Zhongkai University of Agriculture and Engineering(G2360221)

Study on Synthesis and Chloramphenicol Release of Poly(2-hydroxyethylmethacrylate-co-acrylamide)Hydrogels

LI Xinming, CUI Yingde

School of Chemistry, Chemical Engineering, Zhongkai University of Agriculture, Engineering, Guangzhou 510225, China

Received:2007-10-23 Revised:2008-03-08 Online:2008-08-28 Published:2008-08-28
Supported by:
the Natural Science Foundation of Guangdong Province(5300978);Zhongkai University of Agriculture and Engineering(G2360221)

摘要/Abstract

摘要： In this article, poly(2-hydroxyethylmethacrylate-co-acrylamide) hydrogels were synthesized by bulk free-radical copolymerization of 2-hydroxyethylmethacrylate (HEMA) and acrylamide (AAm) for soft contact lens(SCL)-based ophthalmic drug delivery system. The copolymer was characterized with FT-IR and SEM, the swelling property of the hydrogels were studied by gravimetrical method, and chloramphenicol was used as a model drug to investigate drug release profile of the hydrogels. The results showed that poly(2-hydroxyethylmethacrylate-co-acrylamide) hydrogels were transparent and useful SCL biomaterial, the water content increased as AAm content increase and pH decrease, and in the same way, hydrogel composition affected chloramphenicol release process too. Migration rate of chloramphenicol increased as the AAm content in the hydrogels increased in the first stage of diffusion process, whereas there was no significant difference thereafter.

关键词: hydrogels, drug delivery, chloramphenicol, pH-sensible

Abstract: In this article, poly(2-hydroxyethylmethacrylate-co-acrylamide) hydrogels were synthesized by bulk free-radical copolymerization of 2-hydroxyethylmethacrylate (HEMA) and acrylamide (AAm) for soft contact lens(SCL)-based ophthalmic drug delivery system. The copolymer was characterized with FT-IR and SEM, the swelling property of the hydrogels were studied by gravimetrical method, and chloramphenicol was used as a model drug to investigate drug release profile of the hydrogels. The results showed that poly(2-hydroxyethylmethacrylate-co-acrylamide) hydrogels were transparent and useful SCL biomaterial, the water content increased as AAm content increase and pH decrease, and in the same way, hydrogel composition affected chloramphenicol release process too. Migration rate of chloramphenicol increased as the AAm content in the hydrogels increased in the first stage of diffusion process, whereas there was no significant difference thereafter.

Key words: hydrogels, drug delivery, chloramphenicol, pH-sensible

黎新明, 崔英德. Study on Synthesis and Chloramphenicol Release of Poly(2-hydroxyethylmethacrylate-co-acrylamide)Hydrogels[J]. , 2008, 16(4): 640-645.

LI Xinming, CUI Yingde. Study on Synthesis and Chloramphenicol Release of Poly(2-hydroxyethylmethacrylate-co-acrylamide)Hydrogels[J]. , 2008, 16(4): 640-645.

参考文献

1 Bourlais, C.L., Acar, L., Zia, H., Sado, P.A., Needham, T., Leverge, R., “Ophthalmic drug delivery systems”, Prog. Retinal Eye Res., 17,33-58 (1998).
2 Creech, J.L., Chauhan, A., Radke, C.J., “Dispersive mixing in the posterior tear film under a soft contact lens”, I&EC Res., 40,3015-3026 (1999).
3 Mc Namara, N.A., Polse, K.A., Brand, R.D., Graham, A.D., Chan, J.S., Mc Kenney, C.D., “Tear mixing under a soft contact lens: Effects of lens diameter”, Am. J. Ophthal., 127, 659-665 (1999).
4 Wilson, C.G., “Topical drug delivery in the eye”, Exp. Eye Res., 78,737-743 (2004).
5 Hughes, P.M., Olejnik, O., Chang-Lin, J.E., Wilson, C.G., “Topical and systemic drug delivery to the posterior segments”, Adv. Drug Del. Rev., 57, 2010-2032 (2005).
6 Lang, J.C., “Ocular drug delivery conventional ocular formulations”, Adv. Drug Delivery., 16, 39-43 (1995).
7 Deshpande, S.G., Shirolkar, S., “Sustained release ophthalmic formulations of pilocarpine”, J. Pharm. Pharmacol., 41, 197-200 (1989).
8 Ding, S., “Recent developments in ophthalmic drug delivery”, Pharm. Sci. Technol. Today., 1, 328-335 (1998).
9 Lin, H.R., Sung, K.C., “Carbopol/pluronic phase change solutions for ophthalmic drug delivery”, J. Controlled Rel., 69, 379-388 (2000).
10 Gulsen, D., Li, C.C., Chauhan, A., “Dispersion of DMPC liposomes in contact lenses for ophthalmic drug delivery”, Current Eye Research, 30 (12), 1071-1080 (2000).
11 Gulsen, D., Chauhan, A., “Ophthalmic drug delivery through contact lenses”, Investig. Ophthal. Vis. Sci., 45 (7), 2342-2347 (2004).
12 Alvarez-Lorenzo, C., Hiratani, H., Concheiro, A., “Contact lenses for drug delivery: Achieving sustained release with novel systems”, Am. J. Drug Deliv., 4 (3), 131-151 (2006).
13 Warlen, M., Matoba, A., Robinson, N., Gay, C., “Ocular delivery of tobramycin with a disposable soft contact lens”, Investig. Ophthal. Vis. Sci., 33 (4), 938 (1992).
14 Andrade-Vivero, P., Fernandez-Gabriel, E., Alvarez-Lorenzo, C., Concheiro, A., “Improving the loading and release of NSAIDs from pHEMA hydrogels by copolymerization with functionalized monomers”, J. Pharm. Sci., 96 (4), 802-813 (2007).
15 Garcia, D.M., Escobar, J.L., Noa, Y., Bada, N., Hernaez, E., Katime, I., “Timolol maleate release from pH-sensible poly (2-hydroxyethyl methacrylate-co-methacrylic acid) hydrogels”, Eur. Polymer J., 40,1683-1690 (2004).
16 Karlgard, C.C.S., Wong, N.S., Jones, L.W., Moresoli, C., “In vitro uptake and release studies of ocular pharmaceutical agents by silicon-containing and p-HEMA hydrogel contact lens materials”, Int. J. Pharm., 257, 141-151 (2003).
17 Winterton, L.C., Lally, J.M., Sentell, K.B., Chapoy, L.L., “The elution of poly (vinyl alcohol) from a contact lens: The realization of a time release moisturizing agent/artificial tear”, J. Biomed. Mater. Res. B-Appl. Biomater., 80B (2), 424-432 (2007).
18 Sano, K., Tokoro, T., Imai, Y., “A new drug delivery system utilizing piggyback contact lenses”, Acta Ophthalmol, 74, 243-248 (1996).
19 Gulsen, D., Chauhan, A., “Dispersion of microemulsion drops in HEMA hydrogel: A potential ophthalmic drug delivery vehicle”, Int. J. Pharm., 292, 95-117 (2005).
20 Uchida, R, Sato, T., Tanigawa, H., Uno, K., “Azulene incorporation and release by hydrogel containing methacrylamide propyltrimethylammonium chloride, and its application to soft contact lens”, J. Control. Release, 92, 259-264 (2003).
21 Sato, T., Uchida, R., Tanigawa, H., Uno, K., Murakami, A., “Application of polymer gels containing side-chain phosphate groups to drug-delivery contact lenses”, J. Appl. Polym. Sci., 98, 731-735 (2005).
22 Alvarez-Lorenzo, C., Hiratani, H., Gomez-Amoza, J.L., Martinez-Pacheco, R., Souto, C., Concheiro, A., “Soft contact lenses capable of sustained delivery of timolol”, J. Pharm. Sci., 91 (10),2182-2192 (2002).
23 Alvarez-Lorenzo, C., Ya ez, F., Barreiro-Iglesias, R., Concheiro, A., “Imprinted soft contact lenses as norfloxacin delivery systems”, J. Control. Release, 113, 236-244 (2006).
24 Hiratani, H., Alvarez-Lorenzo, C., “Timolol uptake and release by imprinted soft contact lenses made of N,N-diethylacrylamide and methacrylic acid”, J. Control. Release, 83, 223-230 (2002).
25 Hiratani, H., Alvarez-Lorenzo, C., “The nature of backbone monomers determines the performance of imprinted soft contact lenses as timolol drug delivery systems”, Biomaterials, 25, 1105-1113 (2004).
26 Hiratani, H., Fujiwara, A., Tamiya, Y., Mizutani, Y., Alvarez-Lorenzo, C., “Ocular release of timolol from molecularly imprinted soft contact lenses”, Biomaterials, 26, 1293-1298 (2005).
27 Venkatesh, S., Sizemore, S.P., Mark, E.B., “Biomimetic hydrogels for enhanced loading and extended release of ocular therapeutics”, Biomaterials, 28, 717-724 (2007).
28 Hiratani, H., Mizutani, Y., Alvarez-Lorenzo, C., “Controlling drug release from imprinted hydrogels by modifying the characteristics of the imprinted cavities”, Macromol. Biosci., 5, 728-733 (2005).
29 Li, C.C., Chauhan, A., “Modeling ophthalmic drug delivery by soaked contact lenses”, Ind. Eng. Chem. Res., 45, 3718-3734 (2006).
30 Thygesen, J.E., Jensen, O.L., “pH changes of the tear fluid in the conjunctival sac during postoperative inflammation of the human eye”, Acta Ophthalmol (Copenh)., 65 (2), 134-136 (1987).
31 Haroldo, C.B.P., Regina, C.M.P., Sterlane, K.F.B., “Swelling and release kinetics of larvicide-containing chitosan/cashew gum beads”, J. Appl. Polym. Sci., 102, 395-400 (2006).

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Study on Synthesis and Chloramphenicol Release of Poly(2-hydroxyethylmethacrylate-co-acrylamide)Hydrogels

Study on Synthesis and Chloramphenicol Release of Poly(2-hydroxyethylmethacrylate-co-acrylamide)Hydrogels

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