Gas-Liquid Microreaction Technology:Recent Developments and Future Challenges

摘要/Abstract

摘要： Gas-liquid microreaction technology has shown great potential in a variety of industrial relevant mass transfer operations and reactions. This paper outlines the current research status of this technology with emphasis on reactor design, hydrodynamics and mass transfer phenomena as well as reaction applications. The future challenges of this important technology are also summarized.

关键词: microchannel, microreactor, two-phase flow, flow pattern, gas-liquid reaction

Abstract: Gas-liquid microreaction technology has shown great potential in a variety of industrial relevant mass transfer operations and reactions. This paper outlines the current research status of this technology with emphasis on reactor design, hydrodynamics and mass transfer phenomena as well as reaction applications. The future challenges of this important technology are also summarized.

Key words: microchannel, microreactor, two-phase flow, flow pattern, gas-liquid reaction

陈光文, 乐军, 袁权. Gas-Liquid Microreaction Technology:Recent Developments and Future Challenges[J]. Chinese Journal of Chemical Engineering, 2008, 16(5): 663-669.

CHEN Guangwen, YUE Jun, YUAN Quan. Gas-Liquid Microreaction Technology:Recent Developments and Future Challenges[J]. Chin.J.Chem.Eng., 2008, 16(5): 663-669.

参考文献

1 Charpentier, J.C., “The triplet ‘molecular processes-product-process' engineering:the future of chemical engineering?”, Chem. Eng. Sci., 57, 4667-4690 (2002).
2 Ehrfeld, W., Hessel, V., L we, H., Microreactors:New Technology for Modern Chemistry, Wiley-VCH, Weinheim (2000).
3 Hessel, V., Hardt, S., L we, H., Chemical Micro process Engineer-ing:Fundamentals, Modelling and Reactions, Wiley-VCH, Wein-heim (2004).
4 Hessel, V., Angeli, P., Gavriilidis, A., L we, H., “Gasliquid and gas-liquid-solid microstructured reactors:contacting principles and applications”, Ind. Eng. Chem. Res., 44, 9750-9769 (2005).
5 Yue, J., Chen, G., Yuan, Q., Luo, L., Le Gall, H., “Mass transfer in gas-liquid flow in microchannels”, J. Chem. Ind. Eng. (China), 57, 1296-1303 (2006). (in Chinese) .
6 Chambers, R.D., Fox, M.A., Holling, D., Nakano, T., Okazoeb, T., Sandford, G., “Elemental fluorine. Part 16. Versatile thin-film gasliquid multi-channel microreactors for effective scaleout”, Lab Chip, 5, 191-198 (2005).
7 J hnisch, K., Baerns, M., Hessel, V., Ehrfeld, W., Haverkamp, V., L we, H., Wille, Ch., Guber, A., “Direct fluorination of toluene using elemental fluorine in gas/liquid microreactors”, J. Fluorine Chem., 105, 117-128 (2000).
8 de Mas, N., Günther, A., Kraus, T., Schmidt, M.A., Jensen, K.F., “Scale-out multilayer gas-liquid microreactor with integrated velocimetry sensors”, Ind. Eng. Chem. Res., 44, 8997-9013 (2005).
9 Yue, J., “Hydrodynamics and mass transfer characteristics in gas-liquid microchannel contactors”, Ph.D. Thesis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian (2008). (in Chinese) .
10 Wenn, D.A., Shaw, J.E.A., Mackenzie, B., “A mesh microreactor for 2-phase reactions”, Lab Chip, 3, 180-186 (2003).
11 TeGrotenhuis, W.E., Cameron, R.J., Viswanathan, V.V., Wegeng, R.S., “Solvent extraction and gas absorption using microchannel contactors”, In:Proceedings of the Third International Conference on Microreaction Technology, Springer Verlag, Berling, 541-549 (2000).
12 Hibara, A., Iwayama, S., Matsuoka, S., Ueno, M., Kikutani, Y., Tokeshi, M., Kitamori, T., “Surface modification method of microchannels for gas-liquid two-phase flow in microchips”, Anal. Chem., 77, 943-947 (2005).
13 Losey, M.W., Schmidt, M.A., Jensen, K.F., “Microfabricated multi-phase packed-bed reactors:characterization of mass transfer and reactions”, Ind. Eng. Chem. Res., 40, 2555-2562 (2001).
14 Yue, J., Chen, G., Yuan, Q., Luo, L., Gonthier, Y., “Hydrodynamics and mass transfer characteristics in gas-liquid flow through a rectangular microchannel”, Chem. Eng. Sci., 62, 2096-2108 (2007).
15 Triplett, K.A., Ghiaasiaan, S.M., Abdel-Khalik, S.I., Sadowski, D.L., “Gas-liquid two-phase flow in microchannels. Part I:Two-phase flow patterns”, Int. J. Multiphase Flow, 25, 377-394 (1999).
16 Chung, P.M.-Y., Kawaji, M., “The effect of channel diameter on adiabatic two-phase flow characteristics in microchannels”, Int. J. Multiphase Flow, 30, 735-761 (2004).
17 Cubaud, T., Ho, C-M., “Transport of bubbles in square microchan-nels”, Phys. Fluids, 16, 4575-4585 (2004).
18 Yue, J., Luo, L., Gonthier, Y., Chen, G., Yuan, Q., “An experimental investigation of gas-liquid two-phase flow in single microchannel contactors”, Chem. Eng. Sci., 63, 4189-4202 (2008).
19 Zhao, T.S., Bi, Q.C., “Cocurrent airwater two-phase flow patterns in vertical triangular microchannels”, Int. J. Multiphase Flow, 27, 765-782 (2001).
20 Akbar, M.K., Plummer, D.A., Ghiaasiaan, S.M., “On gas-liquid two-phase flow regimes in microchannels”, Int. J. Multiphase Flow, 29, 855-865 (2003).
21 Triplett, K.A., Ghiaasiaan, S.M., Abdel-Khalik, S.I., Lemouel, A., McCord, B.N., “Gas-liquid two-phase flow in microchannels. Part II:Void fraction and pressure drop”, Int. J. Multiphase Flow, 25, 395-410 (1999).
22 Yue, J., Chen, G., Yuan, Q., “Pressure drops of single and two-phase flows through T-type microchannel mixers”, Chem. Eng. J., 102, 11-24 (2004).
23 Kreutzer, M.T., Kapteijn, F., Moulijn, J.A., Kleijn, C.R., Heiszwolf, J., “Inertial and interfacial effects on pressure drop of Taylor flow in capillaries”, AIChE J., 51, 2428-2440 (2005).
24 de Mas, N., Gunther, A., Schmidt, M.A., Jensen, K.F., “Microfabricated multiphase reactors for the selective direct fluorination of aromatics”, Ind. Eng. Chem. Res., 42, 698-710 (2003).
25 van Baten, J.M., Krishna, R., “CFD simulations of mass transfer from Taylor bubbles rising in circular capillaries”, Chem. Eng. Sci., 59, 2535-2545 (2004). 26 Ber i , G., Pintar, A., “The role of gas bubbles and liquid slug lengths on mass transport in the Taylor flow through capillaries”, Chem. Eng. Sci., 52, 3709-3719 (1997).
27 Yeong, K.K., Gavriilidis, A., Zapf, R., Hessel, V., “Experimental studies of nitrobenzene hydrogenation in a microstructured falling film reactor”, Chem. Eng. Sci., 59, 3491-3494 (2004).
28 Commenge, J.M., Obein, T., Genin, G., Framboisier, X., Rode, S., Schanen, V., Pitiot, P., Matlosz, M., “Gasphase residence time distribution in a falling-film microreactor”, Chem. Eng. Sci., 61, 597-604 (2006).
29 Zanfir, M., Gavriilidis, A., Wille, Ch., Hessel, V., “Carbon dioxide absorption in a falling film microstructured reactors:experiments and modeling”, Ind. Eng. Chem. Res., 44, 1742-1751 (2005).
30 Abdallah, R., Meille, V., Shaw, J., Wenn, D., de Bellefon, C., “Gasliquid and gas-liquid-solid catalysis in a mesh microreactor”, Chem. Commun., 4, 372-373 (2004).
31 Chambers, R.D., Holling, D., Spink, R.C.H., Sandford, G., “Elemental fluorine. Part 13. Gasliquid thin film microreactors for selective direct fluorination”, Lab Chip, 1, 132-137 (2001).
32 Chambers, R.D., Greenhall, M.P., Hutchinshon, J., “Direct fluorination of 1,3-dicarbonyl compounds”, Tetrahedron, 52, 1-8 (1996).
33 Kobayashi, J., Mori, Y., Okamoto, K., Akiyama, R., Ueno, M., Ki-tamori, T., Kobayashi, S., “A microfluidic device for conducting gasliquid-solid hydrogenation reactions”, Science, 304, 1305-1308 (2004).
34 Inoue, T., Schmidt, M.A., Jensen, K.F., “Microfabricated multiphase reactors for the direct synthesis of hydrogen peroxide from hydrogen and oxygen”, Ind. Eng. Chem. Res., 46, 1153-1160 (2007).
35 Hessel, V., L we, H., Müller, A., Kolb, G., Chemical Micro process Engineering:processing and Plants, WILEYVCH, Weinheim (2005).
36 Pennemann, H., Hessel, V., L we, H., “Chemical microprocess technology-from laboratory-scale to production”, Chem. Eng. Sci., 59, 4789-4794 (2004).
37 van Steijn, V., Kreutzer, M.T., Kleijn, C.R., “μ-PIV study of the formation of segmented flow in microfluidic T-junctions”, Chem. Eng. Sci., 62, 7505-7514 (2007).
38 Hardt, S., Doffing, F., Pennemann, H., “Simulation of hydrodynamic dispersion in gas/liquid microreactors”, In:Proceedings of the Fifth Conference on Modeling and Simulation of Microsystems, 22-25 April, San Juan, Puerto Rico, 54-57 (2002).
39 Yu, Z., Hemminger, O., Fan, L.S., “Experiment and lattice Boltzmann simulation of two-phase gasliquid flows in microchannels”, Chem. Eng. Sci., 62, 7172-7183 (2007).
40 Haverkamp, V., Hessel, V., Liauw, M.A., L we, H., Menges, M.G., “Reactor model for fast reactions in the micro-bubble column and validation”, Ind. Eng. Chem. Res., 46, 8558-8565 (2007).
41 Roy, S., Bauer, T., Al-Dahhan, M., Lehner, P., Turek, T., “Monoliths as multiphase reactors:A review”, AIChE J., 50, 2918-2934 (2004).
42 Jensen, K.F., “Microreaction engineeringis small better?”, Chem. Eng. Sci., 56, 293-303 (2001).
43 Luo, L., Tondeur, D., Le Gall, H., Corbel, S., “Constructal approach and multi-scale components”, Appl. Therm. Eng., 27, 1708-1714 (2007).

[1]	Xuejing He, Zhenlin Li, Ji Wang, Hai Yu. Effects of tube cross-sectional shapes on flow pattern, liquid film and heat transfer of n-pentane across tube bundles[J]. 中国化学工程学报, 2023, 60(8): 16-25.
[2]	Mingzhi Li, Zhikai Liu, Wang Yao, Chao Xu, Yangping Yu, Mei Yang, Guangwen Chen. Ultrasonic cavitation-enabled microfluidic approach toward the continuous synthesis of cesium lead halide perovskite nanocrystals[J]. 中国化学工程学报, 2023, 59(7): 32-41.
[3]	Wenting Fan, Fang Zhao, Ming Chen, Jian Li, Xuhong Guo. An efficient microreactor with continuous serially connected micromixers for the synthesis of superparamagnetic magnetite nanoparticles[J]. 中国化学工程学报, 2023, 59(7): 85-91.
[4]	Ming Chen, Huiyan Jiao, Jun Li, Zhibin Wang, Feng He, Yang Jin. Liquid–liquid two-phase flow in a wire-embedded concentric microchannel: Flow pattern and mass transfer performance[J]. 中国化学工程学报, 2023, 56(4): 281-289.
[5]	Qi Han, Xin-Yuan Zhang, Hai-Bo Wu, Xian-Tai Zhou, Hong-Bing Ji. Different efficiency toward the biomimetic aerobic oxidation of benzyl alcohol in microchannel and bubble column reactors: Hydrodynamic characteristics and gas–liquid mass transfer[J]. 中国化学工程学报, 2023, 55(3): 84-92.
[6]	Chunxin Fan, Zini Guo, Jianhong Luo. Study on an improved rotating microchannel separator in the intensification for demulsification and separation process[J]. 中国化学工程学报, 2023, 55(3): 181-191.
[7]	Qinyan Wang, Yang Jin, Jun Li, Yongbo Zhou, Ming Chen. Study on liquid–liquid two-phase mass transfer characteristics in the microchannel with deformed insert[J]. 中国化学工程学报, 2023, 54(2): 114-126.
[8]	Tengjie Wang, Wenkai Li, Xuehui Ge, Ting Qiu, Xiaoda Wang. Kinetics measurement of ethylene-carbonate synthesis via a fast transesterification by microreactors[J]. 中国化学工程学报, 2023, 53(1): 243-250.
[9]	Yongbo Zhou, Yang Jin, Jun Li, Qinyan Wang, Ming Chen. Numerical study on the hydrodynamics behavior of a central insert microchannel[J]. 中国化学工程学报, 2023, 53(1): 361-373.
[10]	Zewen Chen, Yongjun Wu, Jian Wang, Peicheng Luo. Study on the solid–liquid suspension behavior in a tank stirred by the long-short blades impeller[J]. 中国化学工程学报, 2022, 47(7): 79-88.
[11]	Ye Zhang, Yong Gao, Peng Wang, Duo Na, Zhenming Yang, Jinsong Zhang. Solvent extraction with a three-dimensional reticulated hollow-strut SiC foam microchannel reactor[J]. 中国化学工程学报, 2022, 46(6): 53-62.
[12]	Youfang Ma, Youfu Ma, Junfu Lyu, Weiye Liu. Experimental study on prediction model of wet gas pressure drop across single-orifice plate in horizontal pipes in the low gas phase Froude number region[J]. 中国化学工程学报, 2022, 46(6): 63-72.
[13]	Yaran Yin, Xianming Zhang, Chunying Zhu, Taotao Fu, Youguang Ma. Formation characteristics of Taylor bubbles in a T-junction microchannel with chemical absorption[J]. 中国化学工程学报, 2022, 46(6): 214-222.
[14]	Zhen Chen, Chunying Zhu, Taotao Fu, Xiqun Gao, Youguang Ma. Formation dynamics and size prediction of bubbles for slurry system in T-shape microchannel[J]. 中国化学工程学报, 2022, 45(5): 153-161.
[15]	Shuai Chen, Jiahong Lan, Yu Zhang, Jia Guo, Zhikai Cao, Yong Sha. 3D multiphase flow simulation of Marangoni convection on reactive absorption of CO₂ by monoethanolamine in microchannel[J]. 中国化学工程学报, 2022, 43(3): 370-377.