Experimental study and simulation of a three-phase flow stirred bioreactor

doi:10.1016/j.cjche.2018.06.010

中国化学工程学报 ›› 2019, Vol. 27 ›› Issue (3): 649-659.DOI: 10.1016/j.cjche.2018.06.010

• Biotechnology and Bioengineering • 上一篇下一篇

Experimental study and simulation of a three-phase flow stirred bioreactor

Chenghui Zheng^1,2, Jiashun Guo¹, Chengkai Wang¹, Yuanfeng Chen², Huidong Zheng¹, Zuoyi Yan¹, Qinggen Chen³

1 School of Chemical Engineering, Fuzhou University, Fuzhou 350108, China;
2 Fujian Provincial Academy of Environmental Science, Fuzhou 350013, China;
3 Xiamen Zijin Mining & Metallurgy Technology Co. Ltd., Xiamen 361102, China

收稿日期:2018-03-23 修回日期:2018-05-25 出版日期:2019-03-28 发布日期:2019-04-25
通讯作者: Huidong Zheng,E-mail address:youngman@fzu.edu.cn
基金资助:
Supported by the National Natural Science Foundation of China (21476049,21506033) and Department of Science and Technology of Fujian Province,China (2014R1004-3,2015J01052,2016H4023 and FG-2016005).

Experimental study and simulation of a three-phase flow stirred bioreactor

Chenghui Zheng^1,2, Jiashun Guo¹, Chengkai Wang¹, Yuanfeng Chen², Huidong Zheng¹, Zuoyi Yan¹, Qinggen Chen³

1 School of Chemical Engineering, Fuzhou University, Fuzhou 350108, China;
2 Fujian Provincial Academy of Environmental Science, Fuzhou 350013, China;
3 Xiamen Zijin Mining & Metallurgy Technology Co. Ltd., Xiamen 361102, China

Received:2018-03-23 Revised:2018-05-25 Online:2019-03-28 Published:2019-04-25
Contact: Huidong Zheng,E-mail address:youngman@fzu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China (21476049,21506033) and Department of Science and Technology of Fujian Province,China (2014R1004-3,2015J01052,2016H4023 and FG-2016005).

摘要/Abstract

摘要： In order to obtain the reasonable operating conditions and minimize the power consumption in the stirred bioreactor, the hydrodynamic experiments in the stirred bioreactor have been taken to obtain the basic data. Subsequently, an Eulerian model for the gas-liquid-solid three phase flow in the stirred bioreactor has been proposed and the CFD simulation has been conducted. By comparing the results of experiment and simulation, it can be concluded that the simulation results were consistent with the experimental data. The inner relationship between operating variables and indicators could be obtained by comparing the results of just suspension speed, gas holdup, power consumption and operational maps, further the reasonable operating conditions could be also determined under the minimum power consumption. The operational maps could provide the theoretical foundation for industrial application of the gas-liquid-solid stirred bioreactors under the low solid concentration (no more than 20 wt%).

关键词: Stirred bioreactor, Hydrodynamics experiment, Simulations, Operational maps

Abstract: In order to obtain the reasonable operating conditions and minimize the power consumption in the stirred bioreactor, the hydrodynamic experiments in the stirred bioreactor have been taken to obtain the basic data. Subsequently, an Eulerian model for the gas-liquid-solid three phase flow in the stirred bioreactor has been proposed and the CFD simulation has been conducted. By comparing the results of experiment and simulation, it can be concluded that the simulation results were consistent with the experimental data. The inner relationship between operating variables and indicators could be obtained by comparing the results of just suspension speed, gas holdup, power consumption and operational maps, further the reasonable operating conditions could be also determined under the minimum power consumption. The operational maps could provide the theoretical foundation for industrial application of the gas-liquid-solid stirred bioreactors under the low solid concentration (no more than 20 wt%).

Key words: Stirred bioreactor, Hydrodynamics experiment, Simulations, Operational maps

Chenghui Zheng, Jiashun Guo, Chengkai Wang, Yuanfeng Chen, Huidong Zheng, Zuoyi Yan, Qinggen Chen. Experimental study and simulation of a three-phase flow stirred bioreactor[J]. 中国化学工程学报, 2019, 27(3): 649-659.

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Experimental study and simulation of a three-phase flow stirred bioreactor

Experimental study and simulation of a three-phase flow stirred bioreactor

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