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SCI和EI收录∣中国化工学会会刊

中国化学工程学报 ›› 2022, Vol. 49 ›› Issue (9): 111-121.DOI: 10.1016/j.cjche.2022.01.024

• Special Column: Membranes for Life Science • 上一篇    下一篇

Coordination of thin-film nanofibrous composite dialysis membrane and reduced graphene oxide aerogel adsorbents for elimination of indoxyl sulfate

Yuanyuan Jin, Siping Ding, Peiyun Li, Xuefen Wang   

  1. State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China
  • 收稿日期:2021-09-07 修回日期:2022-01-11 发布日期:2022-10-19
  • 通讯作者: Xuefen Wang,E-mail:wangxf@dhu.edu.cn
  • 基金资助:
    This work was supported by the Fundamental Research Funds for the Central Universities (2232020A-04) and Natural Science Foundation of Shanghai City (19ZR1401300).

Coordination of thin-film nanofibrous composite dialysis membrane and reduced graphene oxide aerogel adsorbents for elimination of indoxyl sulfate

Yuanyuan Jin, Siping Ding, Peiyun Li, Xuefen Wang   

  1. State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China
  • Received:2021-09-07 Revised:2022-01-11 Published:2022-10-19
  • Contact: Xuefen Wang,E-mail:wangxf@dhu.edu.cn
  • Supported by:
    This work was supported by the Fundamental Research Funds for the Central Universities (2232020A-04) and Natural Science Foundation of Shanghai City (19ZR1401300).

PDF (PC)

摘要： The protein-bound uremic toxins, represented by indoxyl sulfate (IS), have been associated with the progression of chronic kidney disease and the development of cardiovascular disease in the presence of impaired renal function. Herein, we proposed a novel strategy of thin-film nanofibrous composite (TNFC) dialysis membrane combined with reduced graphene oxide (rGO) aerogel adsorbents for clinical removal of IS as well as high retention of proteins. The TFNC membrane was prepared by electrospinning in conjunction with coating-reaction method and proved to have good selectivity and permeability. To further improve the removal rate of toxins, we used a medium hydrothermal method following by freeze-drying treatment to obtain the rGO aerogel adsorbents. It exhibited excellent adsorption for IS with a maximum adsorption capacity of 69.40 mg·g-1 through π-π interaction and hydrogen bonding interaction based on Langmuir isotherm models. Time-dependent absorption experiments showed that it reached adsorption equilibrium within 4 h, which was matched with the hemodialysis time. The coordination was significantly exhibited by introducing rGO aerogel blocks into the dialysate for absorbing the diffused free IS during hemodialysis. Taking the advantages of the TFNC dialysis membrane and the rGO aerogel, the volume of dialysate for hemodialysis was only one-tenth of that without adsorbent blocks but with very comparable dialysis performance (the clearance of IS at 51.8% and the retention of HSA over 98%), which could lighten conventional hemodialysis effectively and be benefit to realize the miniaturization of the hemodialysis equipment. Therefore, the coordination of the TFNC dialysis membrane and rGO aerogel adsorbents would open a new path for the development of portable artificial kidney.

关键词: Indoxyl sulfate, Thin-film nanofibrous composite membrane, rGO aerogel adsorbents, Hemodialysis, Coordination, Portable artificial kidney

Abstract: The protein-bound uremic toxins, represented by indoxyl sulfate (IS), have been associated with the progression of chronic kidney disease and the development of cardiovascular disease in the presence of impaired renal function. Herein, we proposed a novel strategy of thin-film nanofibrous composite (TNFC) dialysis membrane combined with reduced graphene oxide (rGO) aerogel adsorbents for clinical removal of IS as well as high retention of proteins. The TFNC membrane was prepared by electrospinning in conjunction with coating-reaction method and proved to have good selectivity and permeability. To further improve the removal rate of toxins, we used a medium hydrothermal method following by freeze-drying treatment to obtain the rGO aerogel adsorbents. It exhibited excellent adsorption for IS with a maximum adsorption capacity of 69.40 mg·g-1 through π-π interaction and hydrogen bonding interaction based on Langmuir isotherm models. Time-dependent absorption experiments showed that it reached adsorption equilibrium within 4 h, which was matched with the hemodialysis time. The coordination was significantly exhibited by introducing rGO aerogel blocks into the dialysate for absorbing the diffused free IS during hemodialysis. Taking the advantages of the TFNC dialysis membrane and the rGO aerogel, the volume of dialysate for hemodialysis was only one-tenth of that without adsorbent blocks but with very comparable dialysis performance (the clearance of IS at 51.8% and the retention of HSA over 98%), which could lighten conventional hemodialysis effectively and be benefit to realize the miniaturization of the hemodialysis equipment. Therefore, the coordination of the TFNC dialysis membrane and rGO aerogel adsorbents would open a new path for the development of portable artificial kidney.

Key words: Indoxyl sulfate, Thin-film nanofibrous composite membrane, rGO aerogel adsorbents, Hemodialysis, Coordination, Portable artificial kidney

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