Preparation of Ultra-fine Salbutamol Sulfate Particles by Reactive Precipitation and Characterization of Dry Powder Inhalant

›› 2008, Vol. 16 ›› Issue (5): 791-795.

Preparation of Ultra-fine Salbutamol Sulfate Particles by Reactive Precipitation and Characterization of Dry Powder Inhalant

续京¹, 刘晓林², 陈建峰²

1. Ningxia University, Yinchuan 750021, China;
2. Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University ofChemical Technology, Beijing 100029, China

收稿日期:2007-12-04 修回日期:2008-06-02 出版日期:2008-10-28 发布日期:2008-10-28
通讯作者: LIU Xiaolin,E-mail:Liuxl@mail.buct.edu.cn
基金资助:
the National High Technology Research and Development Program of China(2001AA218061);the National Natural Science Foundation of China(20236020).

Preparation of Ultra-fine Salbutamol Sulfate Particles by Reactive Precipitation and Characterization of Dry Powder Inhalant

XU Jing¹, LIU Xiaolin², CHEN Jianfeng²

1. Ningxia University, Yinchuan 750021, China;
2. Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University ofChemical Technology, Beijing 100029, China

Received:2007-12-04 Revised:2008-06-02 Online:2008-10-28 Published:2008-10-28
Supported by:
the National High Technology Research and Development Program of China(2001AA218061);the National Natural Science Foundation of China(20236020).

摘要/Abstract

摘要： The preparation of ultra-fine particles of salbutamol sulphate(SS)was accomplished with a reactive precipitation pathway,in which salbutamol and sulphuric acid were used as reactants with the solvents of ethanol. The effects of sulphuric acid concentration,reaction temperature,stirring rate,and reaction time on the size of the particle were investigated.A binary mixture composed of lactose and SS was prepared to evaluate SS.The results showed that ultra-fine SS particles with controlled diameters ranging between 3μm and 0.8μm and with a narrow distribution could be achieved.The morphology consisting of clubbed particles was successfully obtained.The purity of the particles reached above 98% with UV detection.The dose of dry powder inhalation was obtained by blending the particles with recrystallized lactose,which acted as a carrier.The deposition quantity of the drug in breathing tract was estimated using a twin impinger apparatus.Compared with the Shapuer powder(purchased in the market),the results showed that SS particles had more quantities subsided in simulative lung.

关键词: salbutamol sulphate, ultra-fine particle, reactive precipitation, preparation, dry powder inhalant, deposition

Abstract: The preparation of ultra-fine particles of salbutamol sulphate(SS)was accomplished with a reactive precipitation pathway,in which salbutamol and sulphuric acid were used as reactants with the solvents of ethanol. The effects of sulphuric acid concentration,reaction temperature,stirring rate,and reaction time on the size of the particle were investigated.A binary mixture composed of lactose and SS was prepared to evaluate SS.The results showed that ultra-fine SS particles with controlled diameters ranging between 3μm and 0.8μm and with a narrow distribution could be achieved.The morphology consisting of clubbed particles was successfully obtained.The purity of the particles reached above 98% with UV detection.The dose of dry powder inhalation was obtained by blending the particles with recrystallized lactose,which acted as a carrier.The deposition quantity of the drug in breathing tract was estimated using a twin impinger apparatus.Compared with the Shapuer powder(purchased in the market),the results showed that SS particles had more quantities subsided in simulative lung.

Key words: salbutamol sulphate, ultra-fine particle, reactive precipitation, preparation, dry powder inhalant, deposition

续京, 刘晓林, 陈建峰. Preparation of Ultra-fine Salbutamol Sulfate Particles by Reactive Precipitation and Characterization of Dry Powder Inhalant[J]. , 2008, 16(5): 791-795.

XU Jing, LIU Xiaolin, CHEN Jianfeng. Preparation of Ultra-fine Salbutamol Sulfate Particles by Reactive Precipitation and Characterization of Dry Powder Inhalant[J]. , 2008, 16(5): 791-795.

参考文献

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Preparation of Ultra-fine Salbutamol Sulfate Particles by Reactive Precipitation and Characterization of Dry Powder Inhalant

Preparation of Ultra-fine Salbutamol Sulfate Particles by Reactive Precipitation and Characterization of Dry Powder Inhalant

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