Injectable self-healing nanocellulose hydrogels crosslinked by aluminum: Cellulose nanocrystals vs. cellulose nanofibrils

doi:10.1016/j.cjche.2022.04.026

中国化学工程学报 ›› 2022, Vol. 50 ›› Issue (10): 389-397.DOI: 10.1016/j.cjche.2022.04.026

• Materials and Product Engineering • 上一篇下一篇

Injectable self-healing nanocellulose hydrogels crosslinked by aluminum: Cellulose nanocrystals vs. cellulose nanofibrils

Zhongxin Lin¹, Renliang Huang^2,3, Jiangjiexing Wu^2,3, Anastasia Penkova⁴, Wei Qi¹, Zhimin He¹, Rongxin Su^1,2,3

1 State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;
2 Zhejiang Institute of Tianjin University, Ningbo 315201, China;
3 School of Marine Science and Technology, Tianjin University, Tianjin 300072, China;
4 St. Petersburg State University, 7/9 Universitetskaya nab., 199034 Saint Petersburg, Russia

收稿日期:2022-02-13 修回日期:2022-04-15 出版日期:2022-10-28 发布日期:2023-01-04
通讯作者: Jiangjiexing Wu,E-mail:wujiangjiexing2007@126.com;Rongxin Su,E-mail:surx@tju.edu.cn
基金资助:
This work was supported by the National Key Research and Development Program of China (2019YFE0106900).

Injectable self-healing nanocellulose hydrogels crosslinked by aluminum: Cellulose nanocrystals vs. cellulose nanofibrils

Zhongxin Lin¹, Renliang Huang^2,3, Jiangjiexing Wu^2,3, Anastasia Penkova⁴, Wei Qi¹, Zhimin He¹, Rongxin Su^1,2,3

1 State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;
2 Zhejiang Institute of Tianjin University, Ningbo 315201, China;
3 School of Marine Science and Technology, Tianjin University, Tianjin 300072, China;
4 St. Petersburg State University, 7/9 Universitetskaya nab., 199034 Saint Petersburg, Russia

Received:2022-02-13 Revised:2022-04-15 Online:2022-10-28 Published:2023-01-04
Contact: Jiangjiexing Wu,E-mail:wujiangjiexing2007@126.com;Rongxin Su,E-mail:surx@tju.edu.cn
Supported by:
This work was supported by the National Key Research and Development Program of China (2019YFE0106900).

摘要/Abstract

摘要： With excellent biocompatibility and unique physiochemical properties, nanocelluloses including cellulose nanocrystals (CNCs) and cellulose nanofibrils (CNFs) are promising candidates for preparing biomedical hydrogels. CNCs and CNFs are different in morphology and surface charges. Herein, CNCs and two CNFs (CNFs-C, Carboxylated CNFs; CNFs-P, Phosphorylated CNFs) were synthesized and applied to fabricate hydrogels through metal crosslinking. Aluminum crosslinking was found to be the best choice for enhancing the strength. This study systematically compared the morphologies, storage modulus, loss factor, continuous shear ramp, self-healing, swelling, in vitro degradation and injectable properties of the fabricated hydrogels. Further, a radar chart is summarized as guidelines to direct the rational selection to meet the specific requirements of further biomedical applications. At the same nanocellulose concentration and after Al³⁺ crosslinking, CNCs hydrogels had strong water holding capacity twice as much as that of CNFs hydrogels. While CNFs hydrogels showed higher hardness and stronger resistance to degradation than that of CNCs. These results provide detailed insights into nanocellulose hydrogels, making it possible to use these guidelines to select hydrogels for desired performance.

关键词: Cellulose nanocrystals, Cellulose nanofibrils, Surface heterogeneities, Gels, Fabrication, Mechanical properties

Abstract: With excellent biocompatibility and unique physiochemical properties, nanocelluloses including cellulose nanocrystals (CNCs) and cellulose nanofibrils (CNFs) are promising candidates for preparing biomedical hydrogels. CNCs and CNFs are different in morphology and surface charges. Herein, CNCs and two CNFs (CNFs-C, Carboxylated CNFs; CNFs-P, Phosphorylated CNFs) were synthesized and applied to fabricate hydrogels through metal crosslinking. Aluminum crosslinking was found to be the best choice for enhancing the strength. This study systematically compared the morphologies, storage modulus, loss factor, continuous shear ramp, self-healing, swelling, in vitro degradation and injectable properties of the fabricated hydrogels. Further, a radar chart is summarized as guidelines to direct the rational selection to meet the specific requirements of further biomedical applications. At the same nanocellulose concentration and after Al³⁺ crosslinking, CNCs hydrogels had strong water holding capacity twice as much as that of CNFs hydrogels. While CNFs hydrogels showed higher hardness and stronger resistance to degradation than that of CNCs. These results provide detailed insights into nanocellulose hydrogels, making it possible to use these guidelines to select hydrogels for desired performance.

Key words: Cellulose nanocrystals, Cellulose nanofibrils, Surface heterogeneities, Gels, Fabrication, Mechanical properties

Zhongxin Lin, Renliang Huang, Jiangjiexing Wu, Anastasia Penkova, Wei Qi, Zhimin He, Rongxin Su. Injectable self-healing nanocellulose hydrogels crosslinked by aluminum: Cellulose nanocrystals vs. cellulose nanofibrils[J]. 中国化学工程学报, 2022, 50(10): 389-397.

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Injectable self-healing nanocellulose hydrogels crosslinked by aluminum: Cellulose nanocrystals vs. cellulose nanofibrils

Injectable self-healing nanocellulose hydrogels crosslinked by aluminum: Cellulose nanocrystals vs. cellulose nanofibrils

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