SCI和EI收录∣中国化工学会会刊

Chinese Journal of Chemical Engineering ›› 2022, Vol. 49 ›› Issue (9): 46-75.DOI: 10.1016/j.cjche.2022.05.027

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Membranes for extracorporeal membrane oxygenator (ECMO): History, preparation, modification and mass transfer

Ting He1,2, Songhong Yu1,2, Jinhui He1,2, Dejian Chen1,2, Jie Li1,2, Hongjun Hu1,2, Xingrui Zhong1,2, Yawei Wang4, Zhaohui Wang1,2,3, Zhaoliang Cui1,2,3   

  1. 1. State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 210009, China;
    2. National Engineering Research Center for Special Separation Membrane, Nanjing Tech University, Nanjing 210009, China;
    3. Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing 210009, China;
    4. Beijing Aerospace Changfeng Co., Ltd., Beijing 100854, China
  • Received:2021-10-01 Revised:2022-05-09 Online:2022-10-19 Published:2022-09-28
  • Contact: Zhaohui Wang,E-mail:zhwang@njut.edu.cn;Zhaoliang Cui,E-mail:zcui@njtech.edu.cn
  • Supported by:
    The authors would like to express their appreciation for the financial support of the National Key Research and Development Program of China (2020YFC0862903), the National Natural Science Foundation of China (22078146), the Key Research and Development program of Jiangsu Province (BE2021022), and the Natural Science Foundation of Jiangsu Province (BK20200091).

Membranes for extracorporeal membrane oxygenator (ECMO): History, preparation, modification and mass transfer

Ting He1,2, Songhong Yu1,2, Jinhui He1,2, Dejian Chen1,2, Jie Li1,2, Hongjun Hu1,2, Xingrui Zhong1,2, Yawei Wang4, Zhaohui Wang1,2,3, Zhaoliang Cui1,2,3   

  1. 1. State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 210009, China;
    2. National Engineering Research Center for Special Separation Membrane, Nanjing Tech University, Nanjing 210009, China;
    3. Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing 210009, China;
    4. Beijing Aerospace Changfeng Co., Ltd., Beijing 100854, China
  • 通讯作者: Zhaohui Wang,E-mail:zhwang@njut.edu.cn;Zhaoliang Cui,E-mail:zcui@njtech.edu.cn
  • 基金资助:
    The authors would like to express their appreciation for the financial support of the National Key Research and Development Program of China (2020YFC0862903), the National Natural Science Foundation of China (22078146), the Key Research and Development program of Jiangsu Province (BE2021022), and the Natural Science Foundation of Jiangsu Province (BK20200091).

Abstract: Extracorporeal membrane oxygenator (ECMO) has been in development for nearly 70 years, and the oxygenator has gone through several generations of optimizations, with advances from bubble oxygenators to membrane oxygenators leading to more and more widespread use of ECMO. Membrane is the core of a ECMO system and the working mechanism of membrane oxygenator depends on the membrane material, from PDMS flat membrane to PMP hollow fiber membrane, which have experienced three generations. Blood compatibility on the surface of the membrane material is very vital, which directly determines the use duration of the oxygenator and can reduce the occurrence of complications. The mechanism of mass transfer is the basis of oxygenator operation and optimization. This review summarizes the membrane development history and preparation technology, modification approaches and mass transfer theory in the process of oxygen and blood exchange. We hoped that this review will provide more ideas for the study of gas blood exchange membrane.

Key words: Extracorporeal membrane oxygenator, Hollow fiber membrane, Fabrication, Surface modification, Mass transfer

摘要: Extracorporeal membrane oxygenator (ECMO) has been in development for nearly 70 years, and the oxygenator has gone through several generations of optimizations, with advances from bubble oxygenators to membrane oxygenators leading to more and more widespread use of ECMO. Membrane is the core of a ECMO system and the working mechanism of membrane oxygenator depends on the membrane material, from PDMS flat membrane to PMP hollow fiber membrane, which have experienced three generations. Blood compatibility on the surface of the membrane material is very vital, which directly determines the use duration of the oxygenator and can reduce the occurrence of complications. The mechanism of mass transfer is the basis of oxygenator operation and optimization. This review summarizes the membrane development history and preparation technology, modification approaches and mass transfer theory in the process of oxygen and blood exchange. We hoped that this review will provide more ideas for the study of gas blood exchange membrane.

关键词: Extracorporeal membrane oxygenator, Hollow fiber membrane, Fabrication, Surface modification, Mass transfer