A functional PES membrane for hemodialysis—Preparation, characterization and biocompatibility

doi:10.1016/j.cjche.2015.04.009

Chinese Journal of Chemical Engineering ›› 2015, Vol. 23 ›› Issue (7): 1236-1244.DOI: 10.1016/j.cjche.2015.04.009

• 材料与产品工程 • 上一篇

A functional PES membrane for hemodialysis—Preparation, characterization and biocompatibility

Noel Jacob Kaleekkal, A. Thanigaivelan, M. Tarun, D. Mohan

Membrane Laboratory, Department of Chemical Engineering, Anna University, Chennai, India

收稿日期:2014-08-12 修回日期:2015-01-25 出版日期:2015-07-28 发布日期:2015-08-21
通讯作者: D. Mohan
基金资助:
We would like to thank Dr. S. Senthil Kumar for his valuable assistance with the biocompatibility characterizations. This study was supported by the Department of Science and Technology (DST), Government of India (IDP/MED/2010/17/2(General)).

A functional PES membrane for hemodialysis—Preparation, characterization and biocompatibility

Noel Jacob Kaleekkal, A. Thanigaivelan, M. Tarun, D. Mohan

Membrane Laboratory, Department of Chemical Engineering, Anna University, Chennai, India

Received:2014-08-12 Revised:2015-01-25 Online:2015-07-28 Published:2015-08-21
Contact: D. Mohan
Supported by:
We would like to thank Dr. S. Senthil Kumar for his valuable assistance with the biocompatibility characterizations. This study was supported by the Department of Science and Technology (DST), Government of India (IDP/MED/2010/17/2(General)).

摘要/Abstract

摘要： In this work, we evaluate the properties of solution casted polysulfone (PSf)/sulfonated polyethersulfone (SPES) blend membranes prepared by non-solvent induced phase inversion technique. The morphologies of these blend membranes, observed using scanning electron microscopy (SEM) and atomic force microscopy (AFM) imaging, indicated a smoother skin layer and an increased number of highly interconnected pores in the sub layer. The efficacy of the prepared membranes was evaluated in terms of porosity, ultrafiltration rate (UFR), molecular weight cut-off (MWCO) and mean pore size. The hydrophilicity of these membranes was in consonance with contact angle values. It was observed that the selectivity and the UFR of the blend membranes were higher when compared to pristine membranes. Furthermore, these blend membranes demonstrated an increase in biocompatibility—prolonged blood clotting time, suppressed platelet adhesion, reduced protein adsorption and lower complement activation. These membranes were also investigated for uremic solute removal. Diffusive permeability of middle molecular weight cytochrome-c revealed an increase from 8 × 10^-4 cm·s^-1 to 18 × 10^-4 cm·s^-1 and illustrates the possibility that these sulfonated PES/PSf blend membranes can be used to prepare membrane modules for hemodialysis applications.

关键词: Sulfonated polyethersulfone, Hydrophilicity, Diffusive permeability, Biocompatibility, Molecular weight cut-off

Abstract: In this work, we evaluate the properties of solution casted polysulfone (PSf)/sulfonated polyethersulfone (SPES) blend membranes prepared by non-solvent induced phase inversion technique. The morphologies of these blend membranes, observed using scanning electron microscopy (SEM) and atomic force microscopy (AFM) imaging, indicated a smoother skin layer and an increased number of highly interconnected pores in the sub layer. The efficacy of the prepared membranes was evaluated in terms of porosity, ultrafiltration rate (UFR), molecular weight cut-off (MWCO) and mean pore size. The hydrophilicity of these membranes was in consonance with contact angle values. It was observed that the selectivity and the UFR of the blend membranes were higher when compared to pristine membranes. Furthermore, these blend membranes demonstrated an increase in biocompatibility—prolonged blood clotting time, suppressed platelet adhesion, reduced protein adsorption and lower complement activation. These membranes were also investigated for uremic solute removal. Diffusive permeability of middle molecular weight cytochrome-c revealed an increase from 8 × 10^-4 cm·s^-1 to 18 × 10^-4 cm·s^-1 and illustrates the possibility that these sulfonated PES/PSf blend membranes can be used to prepare membrane modules for hemodialysis applications.

Key words: Sulfonated polyethersulfone, Hydrophilicity, Diffusive permeability, Biocompatibility, Molecular weight cut-off

Noel Jacob Kaleekkal, A. Thanigaivelan, M. Tarun, D. Mohan. A functional PES membrane for hemodialysis—Preparation, characterization and biocompatibility[J]. Chinese Journal of Chemical Engineering, 2015, 23(7): 1236-1244.

Noel Jacob Kaleekkal, A. Thanigaivelan, M. Tarun, D. Mohan. A functional PES membrane for hemodialysis—Preparation, characterization and biocompatibility[J]. Chin.J.Chem.Eng., 2015, 23(7): 1236-1244.

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A functional PES membrane for hemodialysis—Preparation, characterization and biocompatibility

A functional PES membrane for hemodialysis—Preparation, characterization and biocompatibility

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